A clinical trial to study the effects of glutamine (an amino acid)supplementation in patients with acute pancreatitis.
Not Applicable
- Conditions
- Health Condition 1: null- Pateints admitted to the deptt of Gastroenterology AIIMS with acute pancreatitis
- Registration Number
- CTRI/2009/091/000945
- Lead Sponsor
- ICMR
- Brief Summary
Not available
- Detailed Description
Not available
Recruitment & Eligibility
- Status
- Open to Recruitment
- Sex
- Not specified
- Target Recruitment
- 60
Inclusion Criteria
All patients admitted to gastroenterology ward of AIIMS with acute pancreatitis defined by compatible abdominal pain associated with raised S amylase >3xULN and suggestive imaging shall be included.Among those with severe acute pancreatitis shall be included in the study
Exclusion Criteria
<18 yrs to > 80 yrs
Renal failure at onset or within 7 days of study
Patients who had already received enteral nutrition prior to inclusion in the study.
Absence of
-Advanced. Chronic Liver Disease,
-Inflammatory Bowel Disease
-Celiac disease
-Cystic fibrosis
-Major surgery
-Patient already on NSAIDS
-Pregnancy
-Lack of informed consent
Study & Design
- Study Type
- Interventional
- Study Design
- Not specified
- Primary Outcome Measures
Name Time Method To evaluate change in intestinal permeability (IP) in patients with SAP at onset followed by repeat evaluation of IP after oral Glutamine supplementation compared to those who receive whey protein. <br>Change in endotoxin levels (markers of endotoxemia IgG and IgM) in both groups after supplementation.<br>Timepoint: 7 days after supplementation, <br>Tests will be done pre supplementation and 7 days after supplementation.<br>
- Secondary Outcome Measures
Name Time Method biochemiA.Clinical<br>Infectious complication<br>Total hospital stay<br>Other infectious complication<br>Duration of ICU stay<br>B.Biochemical parameters<br>CRP<br>Pre-albumin<br>Timepoint: for clinical secondary outcome entire hospital stay will be included<br>for biochemical parameters will be done prior to and 7 days after supplementation