Spatial and temporal dynamics of emotional memory consolidatio

Recruiting

• Conditions: traumatic memory and pathological fear; 10002861

• Registration Number: NL-OMON40617
• Lead Sponsor: Radboud Universiteit Nijmegen

Brief Summary

Not available

Detailed Description

Not available

Study Timeline

• Last Update Posted: 23 April 2024

Recruitment & Eligibility

• Status: Recruiting
• Sex: Not specified
• Target Recruitment: 96

Inclusion Criteria

•Healthy volunteers between 18 and 45 years of age (balanced for gender)
•Predominant right-handedness.

Exclusion Criteria

• Abnormal hearing or (uncorrected) vision.
• Average use of more than 3 alcoholic beverages daily.
• Average use of psychotropic medication or recreational drugs weekly or more.
• Habitual smoking, i.e. more than a package of cigarettes per week and a self-reported inability or unease to cease smoking for 24 hours prior to testing.
• Use of psychotropic medication, or of recreational drugs over a period of 72 hours prior to each test session, and use of alcohol within the last 24 hours before each measurement.
• Regular use of corticosteroids.
• Metal objects in or around the body (braces, pacemaker, metal fragments, hearing devices).
• History of psychiatric treatment or current psychiatric treatment.
• History of neurological treatment or current neurological treatment.
• History of endocrine treatment or current endocrine treatment.
• History of autonomic failure (e.g., vasovagal reflex syncope).
• Current parodontitis (only in study arm 1).
• Claustrophobia.
• Intense daily physical exercise.
• Irregular sleep/wake rhythm (e.g., regular nightshifts or cross timeline travel).
• BDI score higher than 13.

Study & Design

• Study Type: Interventional
• Study Design: Not specified

Primary Outcome Measures

Name	Time	Method
<p>Functional Magnetic Resonance Imaging (fMRI)<br /><br>Behavioural measures (e.g. memory accuracy and response bias)</p><br>

Secondary Outcome Measures

Name	Time	Method
<p>Salivary levels of cortisol and alpha-amylase<br /><br>Psychophysiological recordings (pupil dilation, respiration, heart rate, skin<br /><br>conductance, blood pressure)</p><br>