Cranial MRI and fMRI with chemosensory stimulation examining patients with persisting chemosensory dysfunction post COVID-19

Conditions: U09.9
Post COVID-19 condition, unspecified

Registration Number: DRKS00028908

Lead Sponsor: Klinik für Hals-, Nasen und Ohrenheilkunde,Kopf- und Halschirurgie

Brief Summary: Not available

Detailed Description: Not available

Recruitment & Eligibility

Status: Pending

Sex: All

Target Recruitment: 60

Inclusion Criteria

age = 18 years
- declaration of consent in written form
- previous participation in the COVIDOM-study at the UKSH Campus Kiel

Exclusion Criteria

- claustrophobia with the need to take tranquilizers for MRI
- allergy to fragrances
- non-removable implants, e.g. pacemakers, device for deep brain stimulation, insulin-pump/implanted blood glucose meter
- every form of chemosensory dysfunction, which goes back to any root cause other than COVID-19 infection (e.g. traumatic brain injury, pregnancy, chronic sinusitis with and without polyposis, allergic and non-allergic rhinitis, neurodegenerative disorders (e.g. Morbus Alzheimer, Morbus Parkinson)
- pregnancy
- alcoholism

Study & Design

Study Type: observational

Study Design: Not specified

Primary Outcome Measures

Name	Time	Method
It will be examined, which morphological and functional differences there are between individuals who have been infected with COVID-19 and suffer persisting chemosensory dysfunction, and those who have been infected but not affected by chemosensory dysfunction.<br><br>The goal hereby is to gain information regarding the pathophysiological root cause in persisting chemosensory dysfunction in COVID-19. <br><br>The results of the study will be the results of chemosensory tests, as well as results of the MRI- and fMRI-examination (like volume and appearance of relevant brain regions, as well as brain activity resulting chemosensory stimulation).

Secondary Outcome Measures