Brain activation in fecal storage, defecation and fecal incontinence: a 1,5T fMRI pilot study in healthy volunteers

Completed

• Conditions: fecal incontinence; 10002112

• Registration Number: NL-OMON47587
• Lead Sponsor: Medisch Universitair Ziekenhuis Maastricht

Brief Summary

Not available

Detailed Description

Not available

Study Timeline

• Last Update Posted: 23 April 2024

Recruitment & Eligibility

• Status: Completed
• Sex: Not specified
• Target Recruitment: 10

Inclusion Criteria

- age: 20-70 years
- both males and females
- fecal continent
- able to understand and signed informed consent

Exclusion Criteria

- Use of pain medication and/or medication known to influence the gastro-intestinal tract
- Neurological illnesses, affecting the central nervous system and/or brain
- Psychiatric illnesses: i.e. claustrophobia, schizofrenia
- Inflammatory bowel disease: Crohn*s disease, colitis ulcerosa
- History of constipation, fecal incontinence or colorectal cancer
- Anal fissures/fistula
- The use of anti-depressives, anti-epileptics, sleep medication, morphine *like medication
- Narcotic/alcohol abuse
- Kidney failure
- Pregnancy
- Any medical implant (except those that are MR safe or MR conditional)
- Retained wires to the body (e.g. temporary pacing);
- Susceptible to cardiac collapse
- Increased risk of heart attack or other cardiac problems
- Cardiac arrhythmias;
- Impaired thermoregulation;
- Morbidly obese;
- Nauseated (aspiration risk)

Study & Design

• Study Type: Observational invasive
• Study Design: Not specified

Primary Outcome Measures

Name	Time	Method
<p>To objectify the BOLD-signal intensity in healthy volunteers during rectal<br /><br>filling and induction of fecal urgency using ballon distention.</p><br>

Secondary Outcome Measures

Name	Time	Method
<p>n.a.</p><br>