CMR-Lupus Comprehensive Approach by Cardiovascular Magnetic Resonance Tomography
Terminated
- Conditions
- Myocardial DiseaseLupus Erythematosus, SystemicCoronary Artery Disease
- Registration Number
- NCT03488654
- Lead Sponsor
- University Hospital, Basel, Switzerland
- Brief Summary
In systemic lupus erythematosus (SLE), cardiac manifestations, e.g. coronary artery disease (CAD) and myocarditis are leading causes of morbidity and mortality. The prevalence of subclinical heart disease in SLE is unknown. We studied whether a comprehensive cardiovascular magnetic resonance (CMR) protocol may be useful for early diagnosis of heart disease in SLE patients without known CAD
- Detailed Description
Not available
Recruitment & Eligibility
- Status
- TERMINATED
- Sex
- All
- Target Recruitment
- 30
Inclusion Criteria
- diagnosis of SLE, as defined by the American College of Rheumatology Classification Criteria for Systemic Lupus Erythematosus
Exclusion Criteria
- age under 18 years
- known coronary artery disease
- impaired renal function with an estimated glomerular filtration rate less than 30 ml/min, estimated by the Modification of Diet in Renal Disease Study Group (MDRD) formula (45)
- devices as pacemakers, implantable cardioverter-defibrillators, insulin pumps and others
- metallic foreign bodies in the eyes, ferromagnetic implants labeled MR unsafe
- allergy against CMR contrast media or adenosine
- presence of chronic atrial fibrillation, 2nd or 3rd degree Atrioventricular (AV)-block, trifascicular block, asthma and severe chronic obstructive pulmonary disease
Study & Design
- Study Type
- OBSERVATIONAL
- Study Design
- Not specified
- Primary Outcome Measures
Name Time Method Prevalence of cardiovascular pathologies identified by CMR in patients with SLE at baseline
- Secondary Outcome Measures
Name Time Method
Trial Locations
- Locations (1)
University Hospital Basel
🇨🇭Basel, Switzerland