Cardiovascular Protective Role of Laser Acupuncture in Systemic Lupus

Not Applicable

Completed

• Conditions: System; Lupus Erythematosus
• Interventions: Device: laser application on acupoints

• Registration Number: NCT04970199
• Lead Sponsor: Cairo University

Brief Summary

Systemic lupus erythematosus is a chronic and multisystemic autoimmune disorder which predominantly affecting women. The most common cause of death in lupus patients affected by disease for more than 5 years is cardiovascular disease due to presence of some factors as oxidative stress, pro-inflammatory cytokines , dyslipidemia, diabetes, and hypertension.

Detailed Description

laser acupuncture (active or sham) for one month (3 days/week ) on acupoint number 14 of GV meridian, acupoint number 4 and 11 of large intestine, acupoint number 34 of gall bladder meridian, acupoint number 3 of liver meridian, acupoint number 4, 12, and 9 of conception vessel meridian, acupoint number 40, 36, and 25 of stomach meridian, acupoint number 6 of spleen meridian, and acupoint number 5 of triple energizer meridian (laser will be applied for 1 min on every acupiont) in lupus females

Study Timeline

• Study First Submitted: 2021-07-11
• Study First Submitted QC: 2021-07-11
• Study Start: 2021-07-12
• Study First Posted: 2021-07-21
• Primary Completion: 2021-11-10
• Study Completion: 2021-11-30
• Status Verified: 2022-01
• Last Update Submitted: 2022-01-14
• Last Update Posted: 2022-01-28

Recruitment & Eligibility

• Status: COMPLETED
• Sex: Female
• Target Recruitment: 60

Inclusion Criteria

• lupus females
• 60 patients

Exclusion Criteria

• pregnancy
• cardiovascular diseases
• respiratory diseases

Study & Design

• Study Type: INTERVENTIONAL
• Study Design: PARALLEL

Arm && Interventions

Group	Intervention	Description
group 1	laser application on acupoints	thirty lupus women received laser acupuncture (active) for one month (3 days week) on acupoint number 14 of GV meridian, acupoint number 4 and 11 of large intestine, acupoint number 34 of gall bladder meridian, acupoint number 3 of liver meridian, acupoint number 4, 12, and 9 of conception vessel meridian, acupoint number 40, 36, and 25 of stomach meridian, acupoint number 6 of spleen meridian, and acupoint number 5 of triple energizer meridian (laser was applied for 1 min on every acupiont).
group 2	laser application on acupoints	thirty lupus women received laser acupuncture (sham) for one month (3 days) on acupoint number 14 of GV meridian, acupoint number 4 and 11 of large intestine, acupoint number 34 of gall bladder meridian, acupoint number 3 of liver meridian, acupoint number 4, 12, and 9 of conception vessel meridian, acupoint number 40, 36, and 25 of stomach meridian, acupoint number 6 of spleen meridian, and acupoint number 5 of triple energizer meridian (laser was be applied for 1 min on every acupiont).

Primary Outcome Measures

Name	Time	Method
Malondialdehyde	It was measured after 4 weeks	anti-oxidative stress factor

Secondary Outcome Measures

Name	Time	Method
diastole	It was measured after 4 weeks	blood pressure
adenosine triphosphate	It was measured after 4 weeks	energy production marker
Glutathione	It was measured after 4 weeks	antioxidant marker
systole	It was measured after 4 weeks	blood pressure
erythrocyte sedimentation rate (1 hour)	It was measured after 4 weeks	inflammatory marker
erythrocyte sedimentation rate (2 hour)	It was measured after 4 weeks	inflammatory marker
blood glucose	It was be measured after 4 weeks	fasting
c reactive protein	It was measured after 4 weeks	inflammatory marker
Nitrate	It was measured after 4 weeks	oxidative stress factor

Trial Locations

Locations (1)

Faculty of Physical Therapy Cairo University; 🇪🇬 Giza, Dokki, Egypt