Comparison of The Effect of Modafinil and Citalopram On The Treatment of Major Depressio

Phase 3

Recruiting

• Conditions: Major depressive disorder.; Major depressive disorder, single episode

• Registration Number: IRCT20201026049152N1
• Lead Sponsor: Ahvaz University of Medical Sciences

Brief Summary

Not available

Detailed Description

Not available

Study Timeline

• Results First Posted: 1900-01-01
• Last Update Posted: 5 January 2021

Recruitment & Eligibility

• Status: Recruiting
• Sex: All
• Target Recruitment: 30

Inclusion Criteria

Age between 18 to 65 years
Diagnosis of clinical Major Depressive Disorder based on the DSM5 criteria
A score above 25 on the Hamilton Depression Rating Scale
Written consent to enter the study from the patient or her /his guardian
The patient is able to take medicine

Exclusion Criteria

Depression caused by physical illness or the use of drugs and substances
Existence of any severe and chronic physical illness (brain, cardiovascular disease, seizure or history of substance abuse)
History of gastric ulcer
Pregnancy
History of alcohol use and substance abuse during the 6 months prior to the start of the project
History of manic episodes
Intellectual disorders
Psychosis
Breastfeeding
High severity of depression such as melancholic and suicidal ideation
History of receiving antidepressant in two to four weeks before starting the drug (eg MAOIs in the last four weeks but SSRIs or mirtazapine or SNRIs in the last two weeks)
History of non-response or shifting with the studied drugs
History of receiving lithium, lamotrigine, sodium valproate, atypical antipsychotics available other than ziprasidone and aripiprazole, in the past two weeks or one month (depending on the half-life of the drug or based on similar studies)
Being treated with Ritalin for any reason
Existence of mixed symptoms in the recent episode
Existence of anxiety disorder, especially panic

Study & Design

• Study Type: interventional
• Study Design: Not specified

Primary Outcome Measures

Name	Time	Method
Depression score on the Hamilton questionnaire. Timepoint: At the beginning of the study and three weeks and six weeks after the start of the intervention. Method of measurement: The Hamilton questionnaire.