IRCT20201026049152N1RecruitingPhase 3
Comparison of The Effect of Modafinil and Citalopram On The Treatment of Major Depression
Trial Snapshot
- Phase
- Phase 3
- Status
- Recruiting
- Enrollment
- 30
Study Overview
Brief Summary
No summary available.
Study Design
- Study Type
- Interventional
Eligibility Criteria
- Ages
- 18 years to 65 years (—)
- Sex
- All
Inclusion Criteria
- •Age between 18 to 65 years
- •Diagnosis of clinical Major Depressive Disorder based on the DSM5 criteria
- •A score above 25 on the Hamilton Depression Rating Scale
- •Written consent to enter the study from the patient or her /his guardian
- •The patient is able to take medicine
Exclusion Criteria
- •Depression caused by physical illness or the use of drugs and substances
- •Existence of any severe and chronic physical illness (brain, cardiovascular disease, seizure or history of substance abuse)
- •History of gastric ulcer
- •History of alcohol use and substance abuse during the 6 months prior to the start of the project
- •History of manic episodes
- •Intellectual disorders
- •Breastfeeding
- •High severity of depression such as melancholic and suicidal ideation
- •History of receiving antidepressant in two to four weeks before starting the drug (eg MAOIs in the last four weeks but SSRIs or mirtazapine or SNRIs in the last two weeks)
- •History of non-response or shifting with the studied drugs
- •History of receiving lithium, lamotrigine, sodium valproate, atypical antipsychotics available other than ziprasidone and aripiprazole, in the past two weeks or one month (depending on the half-life of the drug or based on similar studies)
- •Being treated with Ritalin for any reason
- •Existence of mixed symptoms in the recent episode
- •Existence of anxiety disorder, especially panic
Investigators
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