Effects of GLP-1 Receptor Agonist on Fat Redistribution and Inflammatory Status
- Registration Number
- NCT02118376
- Lead Sponsor
- Shanghai 10th People's Hospital
- Brief Summary
GLP-1 receptor agonists promote fat redistribution in obese women with type 2 diabetes, reduce liver fat content, improve the inflammation state
- Detailed Description
As a treatment for type 2 diabetesGlucagon like peptide -1 (Glucan-like peptide-1, GLP-1) receptor agonists plays the role of promoting insulin secretion, inhibiting glucagon secretion，and also has the central and peripheral effects,it can inhibit appetite,reduce weight.GLP-1 receptor agonists promote fat redistribution in obese women with type 2 diabetes, reduce liver fat content, improve the inflammation state
Recruitment & Eligibility
- Status
- UNKNOWN
- Sex
- Female
- Target Recruitment
- 20
Inclusion Criteria
- Clinical diagnosis of overweight and type 2 diabetes mellitus
Exclusion Criteria
- Poor body condition (severe liver and kidney dysfunction)
- Unknown causes of pancreatitis, chronic pancreatitis, pancreatic resection, stomach operation, malignant tumor, previous use of systemic corticosteroids (local or inhalation of exceptions) heart function or niacin, incomplete
- serious endocrine disease
- genetic disease
Study & Design
- Study Type
- INTERVENTIONAL
- Study Design
- SINGLE_GROUP
- Arm && Interventions
Group Intervention Description exenatide Exenatide exenatide, 5ug, bid, 3months
- Primary Outcome Measures
Name Time Method Dual energy X-ray absorptiometry 3 month fat distribution
- Secondary Outcome Measures
Name Time Method lab testing 3 month inflammation
Trial Locations
- Locations (1)
Shanghai Tenth People' Hospital
🇨🇳Shanghai, Shanghai, China