A COMPARISON OF POST-OPERATIVE ANALGESIC EFFICACY OF OPIOID FREE ANAESTHESIA USING INTRAVENOUS PARACETAMOL, LIGNOCAINE AND MAGNESIUM SULFHATE VERSUS STANDARD OPIOID ANAESTHESIA USING INTRAVENOUS TRAMADOL FOR PREEMPTIVE ANALGESIA IN ABDOMINAL SURGERIES UNDER GENERAL ANAESTHESIA

Not yet recruiting

• Conditions: Medical and Surgical,

• Registration Number: CTRI/2021/04/033097
• Lead Sponsor: JLN medical college Ajmer

Brief Summary

In this study, we will compare post-operative analgesic efficacy of opioid free anaesthesia (OFA) using paracetamol (15mg/kg), lignocaine (2mg/kg) and magnesium sulfate (50mg/kg) verses standard opioid anesthesia (OA) regimen using tramadol (2mg/kg) for preemptive analgesia in Abdominal surgeries under general anaesthesia.**PRIMARY OBJECTIVE**:

· 24hour post-operative analgesic consumption

**SECONDARY OBJECTIVES**:

· Quality of analgesia using (numeric rating scale NRS)

· Duration of post-operative analgesia (time for demand of rescue analgesic)

· Effect on hemodynamic parameters intraoperatively (Hypertension/hypotension or tachycardia/ bradycardia).

· Stress response to laryngoscopy at the time of intubation.

· Recovery time (Aldrete score >9)

· QoR-15 (post- operative patient comfort)

· Sedation (Ramsay sedation score)

· Post operative nausea vomiting (PONV)

· Complications like pruritus, respiratory distress, sedation, bradycardia (<50bpm), hypotension (decrease in SBP>30% baseline or <100mm Hg.

Detailed Description

Not available

Study Timeline

• Last Update Posted: 2021-04-24
• Study Start: 2021-04-30

Recruitment & Eligibility

• Status: Not Yet Recruiting
• Sex: All
• Target Recruitment: 60

Inclusion Criteria

• Patients posted for elective Abdominal surgery under general anaesthesia.
• Age between 18 to 65 years.
• ASA physical status 1 and 2.

Exclusion Criteria

• Pregnant or Breastfeeding women Emergency surgery Patients refusal.
• Patient sensitive / allergic to any of the study drugs.
• Patients with neuro-psychiatric illness.
• Cardiovascular disease patients (1 and 2 degree heart block) Patients on beta blockers.
• Severe bradycardia (HR<50bpm) or LVF.
• Severe hepatic and renal disease.

Study & Design

• Study Type: Interventional
• Study Design: Not specified

Primary Outcome Measures

Name	Time	Method
The primary outcome of our study will be the 24hour post-operative analgesic consumption in both the groups	Outcome will be assessed at 0hr, 2hr, 4hr, 6hr, 8hr, 12hr, 16hr, 20hr and 24hr postoperatively.

Secondary Outcome Measures

Name	Time	Method
Quality of analgesia using( NRS)	Duration of post-operative analgesia

Trial Locations

Locations (1)

JLN medical colleage, Ajmer; 🇮🇳 Ajmer, RAJASTHAN, India

JLN medical colleage, Ajmer

🇮🇳Ajmer, RAJASTHAN, India

Dr Neha

Principal investigator

9446505237

nehasurendran92@gmail.com