Study to Compare the Effectiveness and Safety of Golcadomide Plus R-CHOP vs Placebo Plus R-CHOP in Participants With Previously Untreated High-risk Large B-cell Lymphoma
- Conditions
- Large B-cell Lymphoma
- Interventions
- Registration Number
- NCT06356129
- Lead Sponsor
- Celgene
- Brief Summary
The purpose of this study is to compare the effectiveness and safety of golcadomide in combination with rituximab, cyclophosphamide, doxorubicin, vincristine, and prednisone (R-CHOP) chemotherapy vs placebo in combination with R-CHOP chemotherapy in participants with previously untreated high-risk large B-cell lymphoma (LBCL).
- Detailed Description
Not available
Recruitment & Eligibility
- Status
- RECRUITING
- Sex
- All
- Target Recruitment
- 850
- Histologically confirmed (per local evaluation) diagnosis of de novo, previously untreated large B-cell lymphoma (LBCL) according to 2022 world health organization (WHO) classification including:
i) Diffuse large B-cell lymphoma (DLBCL), not otherwise specified [including germinal center B-cell (GCB) and activated B-cell (ABC) types]
ii) High-grade B-cell lymphoma, with MYC and BCL2 rearrangements (HGBL-MYC/BCL2 double-hit lymphomas)
iii) High-grade B-cell lymphoma, not otherwise specified
iv) T-cell/histiocyte/rich large B-cell lymphoma (THRLBCL)
v) Epstein-Barr virus + DLBCL
- International Prognostic Index (IPI) score 1 or 2 with lactate dehydrogenase (LDH) > 1.3 x upper limit of normal (ULN) and/or bulky disease defined as single lesion of ≥ 7 cm OR IPI ≥ 3.
- Measurable disease defined by at least 1 fluorodeoxyglucose (FDG)-avid lesion for FDG-avid subtype and 1 bi-dimensionally measurable (> 1.5 cm in longest diameter) disease by computed tomography (CT) or magnetic resonance imaging (MRI), as defined by the Lugano classification.
- Must have Ann Arbor Stage II-IV disease.
- Any significant medical condition, active infection, laboratory abnormality, or psychiatric illness that would prevent the participant from participating in the study.
- Any other subtype of lymphoma. Cases of primary mediastinal (thymic) large B-cell lymphoma (PMBCL), primary cutaneous DLBCL-leg type, Grade 3b FL, indolent lymphoma transformed to large B-cell lymphoma (LBCL), Anaplastic lymphoma kinase (ALK) positive large B-cell lymphoma, primary effusion lymphoma, and Burkitt lymphoma.
- Documented or suspected central nervous system (CNS) involvement by lymphoma.
- Other protocol-defined Inclusion/Exclusion criteria apply.
Study & Design
- Study Type
- INTERVENTIONAL
- Study Design
- PARALLEL
- Arm && Interventions
Group Intervention Description Golcadomide + R-CHOP (Rituximab, Doxorubicin, Vincristine, Cyclophosphamide, Prednisone) Golcadomide - Golcadomide + R-CHOP (Rituximab, Doxorubicin, Vincristine, Cyclophosphamide, Prednisone) Rituximab - Golcadomide + R-CHOP (Rituximab, Doxorubicin, Vincristine, Cyclophosphamide, Prednisone) Cyclophosphamide - Golcadomide + R-CHOP (Rituximab, Doxorubicin, Vincristine, Cyclophosphamide, Prednisone) Doxorubicin - Golcadomide + R-CHOP (Rituximab, Doxorubicin, Vincristine, Cyclophosphamide, Prednisone) Vincristine - Golcadomide + R-CHOP (Rituximab, Doxorubicin, Vincristine, Cyclophosphamide, Prednisone) Prednisone - Placebo + R-CHOP Cyclophosphamide - Placebo + R-CHOP Doxorubicin - Placebo + R-CHOP Placebo - Placebo + R-CHOP Rituximab - Placebo + R-CHOP Vincristine - Placebo + R-CHOP Prednisone -
- Primary Outcome Measures
Name Time Method Progression-free survival (PFS) assessed by the Investigator Up to approximately 67 months
- Secondary Outcome Measures
Name Time Method Overall survival (OS) Up to approximately 67 months Second progression-free survival (PFS2) assessed by the Investigator Up to approximately 67 months PFS assessed by the Investigator Up to approximately 67 months Event-free survival (EFS) Up to approximately 67 months Complete Metabolic Response assessed by the Independent Response Adjudication Committee (IRAC) Up to approximately 18 weeks Minimal residual disease (MRD) negativity rate Up to approximately 18 weeks Progression-free survival (PFS) assessed by the IRAC Up to approximately 47 months Objective response (OR) assessed by the Investigator Up to approximately 18 weeks Complete metabolic response (CMR) assessed by the Investigator Up to approximately 18 weeks PFS24 assessed by the Investigator 24 months after randomization Up to 24 months Duration of response (DoR) Up to approximately 67 months Relative dose intensity (%) Up to 18 weeks Number of participants with Adverse Events (AEs) Up to approximately 20 weeks Mean change from baseline in the EORTC QLQ-C30 Up to approximately 67 months Mean change from baseline in the FACT-LymS Up to approximately 67 months Number of participants with treatment-emergent adverse events (TEAEs) Up to approximately 20 weeks Number of participants with laboratory abnormalities Up to approximately 20 weeks Number of participants with vital sign abnormalities Up to approximately 20 weeks Time from randomization to meaningful improvement in primary domains of interest in the European Organization for Research and Treatment of Cancer - Quality of Life C30 (EORTC QLQ-C30) Questionnaire Up to approximately 67 months Time from randomization to meaningful improvement in primary domains of interest in the Functional Assessment of Cancer Treatment-Lymphoma (FACT-LymS) Questionnaire Up to approximately 67 months
Related Research Topics
Explore scientific publications, clinical data analysis, treatment approaches, and expert-compiled information related to the mechanisms and outcomes of this trial. Click any topic for comprehensive research insights.
Trial Locations
- Locations (342)
USA Mitchell Cancer Institute
🇺🇸Mobile, Alabama, United States
Alaska Oncology and Hematology
🇺🇸Anchorage, Alaska, United States
Mayo Clinic in Arizona - Phoenix
🇺🇸Phoenix, Arizona, United States
Local Institution - 0342
🇺🇸San Francisco, California, United States
Florida Cancer Specialists - South
🇺🇸Fort Myers, Florida, United States
Mayo Clinic in Florida
🇺🇸Jacksonville, Florida, United States
D&H Cancer Research Center LLC
🇺🇸Margate, Florida, United States
Mount Sinai Cancer Center
🇺🇸Miami Beach, Florida, United States
Sacred Heart Medical Oncology Group
🇺🇸Pensacola, Florida, United States
Florida Cancer Specialists - North
🇺🇸Saint Petersburg, Florida, United States
Moffitt Cancer Center
🇺🇸Tampa, Florida, United States
Florida Cancer Specialists - East
🇺🇸West Palm Beach, Florida, United States
Cleveland Clinic Florida
🇺🇸Weston, Florida, United States
Emory University School of Medicine- Grady Campus
🇺🇸Atlanta, Georgia, United States
Winship Cancer Institute, Emory University
🇺🇸Atlanta, Georgia, United States
Local Institution - 0182
🇺🇸Chicago, Illinois, United States
Orchard Healthcare Research Inc.
🇺🇸Skokie, Illinois, United States
Mission Cancer + Blood
🇺🇸Waukee, Iowa, United States
The University of Kansas Cancer Center - Westwood
🇺🇸Westwood, Kansas, United States
Local Institution - 0436
🇺🇸Edgewood, Kentucky, United States
Mary Bird Perkins Cancer Center Baton Rouge
🇺🇸Baton Rouge, Louisiana, United States
Local Institution - 0478
🇺🇸Ann Arbor, Michigan, United States
Allina Health Cancer Institute - Abbott Northwestern Hospital
🇺🇸Minneapolis, Minnesota, United States
Mayo Clinic in Rochester, Minnesota
🇺🇸Rochester, Minnesota, United States
Local Institution - 0437
🇺🇸Kansas City, Missouri, United States
Cancer Care Specialists
🇺🇸Reno, Nevada, United States
Astera Cancer Care
🇺🇸East Brunswick, New Jersey, United States
Local Institution - 0480
🇺🇸Hackensack, New Jersey, United States
Atlantic Health System Morristown Medical Center
🇺🇸Morristown, New Jersey, United States
Rutgers Cancer Institute of New Jersey
🇺🇸New Brunswick, New Jersey, United States
Local Institution - 0190
🇺🇸Buffalo, New York, United States
Hematology-Oncology Associates of Central New York, PC
🇺🇸East Syracuse, New York, United States
Local Institution - 0484
🇺🇸New York, New York, United States
Local Institution - 0369
🇺🇸New York, New York, United States
Icahn School of Medicine at Mount Sinai
🇺🇸New York, New York, United States
Local Institution - 0174
🇺🇸Chapel Hill, North Carolina, United States
Local Institution - 0066
🇺🇸Massillon, Ohio, United States
Oklahoma Cancer Specialists and Research Institute
🇺🇸Tulsa, Oklahoma, United States
Oregon Health and Science University
🇺🇸Portland, Oregon, United States
UPMC Hillman Cancer Center
🇺🇸Pittsburgh, Pennsylvania, United States
WellSpan Oncology Research
🇺🇸York, Pennsylvania, United States
Local Institution - 0435
🇺🇸Fort Sam Houston, Texas, United States
Memorial Hermann Hospital - Texas Medical Center
🇺🇸Houston, Texas, United States
University of Texas MD Anderson Cancer Center
🇺🇸Houston, Texas, United States
Virginia Commonwealth University (VCU) Medical Center
🇺🇸Richmond, Virginia, United States
Local Institution - 0465
🇺🇸Tacoma, Washington, United States
Hospital Aleman
🇦🇷Buenos Aires, Ciudad Autónoma De Buenos Aires, Argentina
Local Institution - 0421
🇦🇷Buenos Aires, Ciudad Autónoma De Buenos Aires, Argentina
Clínica Zabala
🇦🇷Buenos Aires, Argentina
Centro de Educación Médica e Investigaciones clínicas "Dr. Norberto Quirno" (CEMIC)
🇦🇷Buenos Aires, Argentina
Instituto Alexander Fleming
🇦🇷Ciudad Autónoma de Buenos Aires, Argentina
Hospital Privado Universitario de Córdoba
🇦🇷Córdoba, Argentina
Gosford Hospital
🇦🇺Gosford, New South Wales, Australia
Campbelltown Hospital
🇦🇺Sydney, New South Wales, Australia
Westmead Hospital
🇦🇺Westmead, New South Wales, Australia
Royal Darwin Hospital
🇦🇺Tiwi, Northern Territory, Australia
Sunshine Coast University Hospital
🇦🇺Birtinya, Queensland, Australia
Gold Coast University Hospital
🇦🇺Southport, Queensland, Australia
Peninsula Private Hospital
🇦🇺Frankston, Victoria, Australia
Austin Health
🇦🇺Heidelberg, Victoria, Australia
Western Health-Sunshine & Footscray Hospitals
🇦🇺St Albans, Victoria, Australia
South West Healthcare
🇦🇺Warrnambool, Victoria, Australia
Klinikum Wels-Grieskirchen GmbH
🇦🇹Wels, Oberösterreich, Austria
Kepler Universitätsklinikum
🇦🇹Linz, Austria
Local Institution - 0386
🇦🇹Vienna, Austria
Núcleo de Oncologia e Hematologia do Ceará
🇧🇷Fortaleza, Ceara, Brazil
Hospital Brasilia
🇧🇷Lago sul, Distrito Federal, Brazil
Universidade Federal de Goias
🇧🇷Goiania, Goias, Brazil
Hospital Erasto Gaertner
🇧🇷Curitiba, Paraná, Brazil
CHN - Complexo Hospitalar de Niterói
🇧🇷Niteroi, Rio De Janeiro, Brazil
Liga Norte Riograndense Contra o Câncer
🇧🇷Natal, Rio Grande Do Norte, Brazil
Centro Gaucho Integrado De Oncologia, Hematologia, Ensino E Pesquisa
🇧🇷Porto Alegre, Rio Grande Do Sul, Brazil
Clínica Supera
🇧🇷Chapecó, Santa Catarina, Brazil
Instituto Joinvilense de Hematologia e Oncologia
🇧🇷Joinville, Santa Catarina, Brazil
Hospital 9 De Julho
🇧🇷São Paulo, SAO Paulo, Brazil
Fundação Pio XII - Hospital de Câncer de Barretos
🇧🇷Barretos, São Paulo, Brazil
Hospital Amaral Carvalho
🇧🇷Jaú, São Paulo, Brazil
Hospital Alemao Oswaldo Cruz
🇧🇷Sao Paulo, São Paulo, Brazil
A. C. Camargo Cancer Center
🇧🇷Sao Paulo, São Paulo, Brazil
Fundação Faculdade Regional de Medicina de São José do Rio Preto
🇧🇷São José do Rio Preto, São Paulo, Brazil
Hospital São Lucas de Copacabana
🇧🇷Rio de Janeiro, Brazil
Instituto D'Or de Pesquisa e Ensino (IDOR)
🇧🇷Sao Paulo, Brazil
Hospital das Clinicas FMUSP
🇧🇷São Paulo, Brazil
Sociedade Beneficente Israelita Brasileira Hospital Albert Einstein
🇧🇷São Paulo, Brazil
University Multiprofile Hospital for Active Treatment "Sveti Georgi" EAD
🇧🇬Plovdiv, Bulgaria
Local Institution - 0392
🇧🇬Sofia, Bulgaria
UMHAT 'Sveti Ivan Rilsky'
🇧🇬Sofia, Bulgaria
Local Institution - 0492
🇨🇦Edmonton, Alberta, Canada
BC Cancer Victoria
🇨🇦Victoria, British Columbia, Canada
St. Marys Hospital Center
🇨🇦Montreal, Quebec, Canada
Centre intégré universitaire de santé et de services sociaux du Nord-de-l'Île-de-Montréal (CIUSSS NÎM) - Hôpital du Sacré-Coeur
🇨🇦Montreal, Quebec, Canada
Centre intégré universitaire de santé et de services sociaux de l'Estrie - Centre Hospitalier Universitaire de Sherbrooke (CIUS
🇨🇦Sherbrooke, Quebec, Canada
Local Institution - 0109
🇨🇱Chile, Región Metropolitana De Santiago, Chile
Fundacion Arturo Lopez Perez (FALP)
🇨🇱Santiago, Región Metropolitana De Santiago, Chile
Clínica Inmunocel
🇨🇱Santiago, Región Metropolitana De Santiago, Chile
Clínica UC San Carlos de Apoquindo
🇨🇱Santiago, Región Metropolitana De Santiago, Chile
Clínica Alemana de Santiago
🇨🇱Santiago, Región Metropolitana De Santiago, Chile
Bradfordhill
🇨🇱Santiago, Región Metropolitana De Santiago, Chile
Centro de Investigaciones
🇨🇱Viña del Mar, Valparaíso, Chile
Peking University Third Hospital
🇨🇳Beijing, Beijing, China
The First Affiliated Hospital of Chongqing Medical University
🇨🇳Chongqing, Chongqing, China
Chongqing University Cancer Hospital
🇨🇳Chongqing, Chongqing, China
Fujian Cancer Hospital
🇨🇳Fuzhou, Fujian, China
The First Affiliated hospital of Xiamen University
🇨🇳Xiamen, Fujian, China
Southern Medical University Nanfang Hospital
🇨🇳Guangzhou, Guangdong, China
Sun Yat-sen University Cancer Center
🇨🇳Guangzhou, Guangdong, China
Guangxi Medical University Affiliated Tumor Hospital
🇨🇳Nanning, Guangxi, China
Harbin Medical University Cancer Hospital
🇨🇳Harbin, Heilongjiang, China
Henan Cancer Hospital
🇨🇳Zhengzhou, Henan, China
Union Hospital Tongji Medical College Huazhong University of Science and Technology
🇨🇳Wuhan, Hubei, China
Tongji Hospital Tongji Medical,Science & Technology
🇨🇳Wuhan, Hubei, China
Hunan Cancer Hospital
🇨🇳Changsha, Hunan, China
The First Affiliated Hospital of Soochow University
🇨🇳Suzhou, Jiangsu, China
The First Affiliated Hospital of Nanchang University
🇨🇳Nanchang, Jiangxi, China
Jiangxi Provincial Cancer Hospital
🇨🇳Nanchang, Jiangxi, China
The First Hospital of Jilin University
🇨🇳Changchun, Jilin, China
The First Hospital of China Medical University
🇨🇳Shenyang, Liaoning, China
Shengjing Hospital of China Medical University
🇨🇳沈阳市, Liaoning, China
Qilu Hospital of Shandong University
🇨🇳Jinan, Shandong, China
Helsinki University Hospital - Comprehensive Cancer Center (HYKS - Syöpäkeskus)
🇫🇮Helsinki, Finland
Shandong Cancer Hospital
🇨🇳Jinan, Shandong, China
Ruijin Hospital Shanghai Jiaotong University School of Medicine
🇨🇳Shanghai, Shanghai, China
Fudan University Shanghai Cancer Center
🇨🇳Shanghai, Shanghai, China
Shanxi Bethune Hospital
🇨🇳Taiyuan, Shanxi, China
West China Hospital, Sichuan University
🇨🇳Cheng Du, Sichuan, China
Local Institution - 0289
🇨🇳Tianjin, Tianjin, China
Tianjin Medical University Cancer Institute & Hospital
🇨🇳Tianjin, Tianjin, China
Local Institution - 0155
🇨🇳Urumchi, Xinjiang, China
Xinjiang Medical University Cancer Hospital - Urumqi
🇨🇳Urumqi, Xinjiang, China
The first Affiliated Hospital, Zhejiang University School of Medicine
🇨🇳Hangzhou, Zhejiang, China
The Second Affiliated hospital of Zhejiang University school of medicine
🇨🇳Hangzhou, Zhejiang, China
The First Affiliated Hospital of Wenzhou Medical University
🇨🇳Wenzhou, Zhejiang, China
Local Institution - 0130
🇨🇴Bogota, Cundinamarca, Colombia
Local Institution - 0129
🇨🇴Bogotá, Distrito Capital De Bogotá, Colombia
Local Institution - 0390
🇭🇷Zagreb, Grad Zagreb, Croatia
Local Institution - 0440
🇭🇷Osijek, Croatia
Fakultní nemocnice Brno Bohunice
🇨🇿Brno, Brno-město, Czechia
Fakultni nemocnice Hradec Kralove
🇨🇿Hradec Kralove, Hradec Králové, Czechia
Fakultni nemocnice Olomouc
🇨🇿Olomouc, Olomoucký Kraj, Czechia
Fakultni Nemocnice Plzen
🇨🇿Pilsen, Plzeňský Kraj, Czechia
Fakultni nemocnice Kralovske Vinohrady
🇨🇿PRague, Praha 10, Czechia
Vseobecna fakultni nemocnice v Praze
🇨🇿Praha 2, Czechia
Aarhus Universitetshospital, Skejby
🇩🇰Aarhus, Midtjylland, Denmark
Odense Universitetshospital
🇩🇰Odense, Syddanmark, Denmark
Oulun yliopistollinen sairaala
🇫🇮Oulu, Pohjois-Pohjanmaa, Finland
Kuopion Yliopistollinen Sairaala
🇫🇮Kuopio, Pohjois-Savo, Finland
Turku University Hospital
🇫🇮Turku, Varsinais-Suomi, Finland
Centre Hospitalier Universitaire de Nice - Hôpital l'Archet
🇫🇷Nice, Alpes-Maritimes, France
Institut de cancérologie Strasbourg Europe (ICANS)
🇫🇷Strasbourg, Alsace, France
Institut Bergonié - Centre Régional de Lutte Contre Le Cancer de Bordeaux et Sud Ouest
🇫🇷Bordeaux, Aquitaine, France
Local Institution - 0324
🇫🇷Pessac, Aquitaine, France
Institut Paoli-Calmettes
🇫🇷Marseille, Bouches-du-Rhône, France
Local Institution - 0292
🇫🇷Dijon, Côte-d'Or, France
Chu Jean Minjoz
🇫🇷Besançon, Doubs, France
CHRU de Brest
🇫🇷Brest, Finistère, France
Institut Curie - site Saint-Cloud
🇫🇷Saint-Cloud, Hauts-de-Seine, France
Centre Hospitalier Régional Universitaire de Tours - Hôpital Bretonneau
🇫🇷Tours, Indre-et-Loire, France
Chu Grenoble Alpes
🇫🇷La Tronche, Isère, France
Centre Hospitalier Sud Réunion
🇫🇷Saint-Pierre, La Réunion, France
Chu Saint Eloi
🇫🇷Montpellier, Languedoc-Roussillon, France
CHU de Saint-Etienne
🇫🇷Saint Priest en Jarez, Loire, France
Hôpital Saint Vincent-de-Paul
🇫🇷Lille, Nord-Pas-de-Calais, France
Hopital Claude Huriez - CHU de Lille
🇫🇷Lille, Nord, France
Centre Hospitalier Universitaire de Nantes - L' Hopital l'hôtel-Dieu
🇫🇷Nantes, Pays-de-la-Loire, France
Centre Hospitalier Lyon Sud
🇫🇷Pierre-Bénite, Rhône, France
Henri Mondor Hospital
🇫🇷Creteil, Val-de-Marne, France
Gustave Roussy
🇫🇷Villejuif, Val-de-Marne, France
Centre Hospitalier Universitaire de Poitiers
🇫🇷Poitiers, Vienne, France
Centre Hospitalier de la Côte Basque
🇫🇷Bayonne, France
Centre Hospitalier Universitaire de Caen - Hôpital Côte de Nacre
🇫🇷Caen, France
Hôpital Saint-Louis
🇫🇷Paris, France
Bundeswehrkrankenhaus Ulm
🇩🇪Ulm, Baden-Württemberg, Germany
Klinikum Augsburg
🇩🇪Augsburg, Bayern, Germany
Local Institution - 0512
🇩🇪Bayreuth, Bayern, Germany
Universitaetsklinikum Erlangen
🇩🇪Erlangen, Bayern, Germany
Gemeinschaftspraxis für Hämatologie und Onkologie
🇩🇪Langen, Hessen, Germany
Local Institution - 0513
🇩🇪Hannover, Niedersachsen, Germany
InVO Institut für Versorgungsforschung in der Onkologie
🇩🇪Koblenz, Rheinland-Pfalz, Germany
Universitätsklinikum Halle
🇩🇪Halle, Sachsen-Anhalt, Germany
Local Institution - 0506
🇩🇪Lübeck, Schleswig-Holstein, Germany
Local Institution - 0508
🇩🇪Berlin, Germany
Medizinische Universität Lausitz- Carl Thiem
🇩🇪Cottbus, Germany
Gemeinschaftspraxis Hämatologie - Onkologie Freiberg-Richter, Jacobasch, Illmer, Wolf
🇩🇪Dresden, Germany
Universitaetsklinikum Essen
🇩🇪Essen, Germany
Evangelismos General Hospital of Athens
🇬🇷Athens, Attikí, Greece
General Hospital of Athens "Laiko"
🇬🇷Athens, Attikí, Greece
Attikon General University Hospital
🇬🇷Chaidari, Attikí, Greece
University Hospital of Alexandroupolis
🇬🇷Alexandroupolis, Greece
University Hospital of Ioannina
🇬🇷Ioannina, Ípeiros, Greece
Debreceni Egyetem Klinikai Kozpont
🇭🇺Debrecen, Hajdú-Bihar, Hungary
Local Institution - 0160
🇭🇺Budapest, Pest, Hungary
Somogy Vármegyei Kaposi Mór Oktató Kórház
🇭🇺Kaposvár, Somogy, Hungary
Szabolcs Szatmár Bereg Vármegyei Oktatókórház
🇭🇺Nyíregyháza, Szabolcs-Szatmár-Bereg, Hungary
Markusovszky Egyetemi Oktatokorhaz
🇭🇺Szombathely, Vas, Hungary
Semmelweis Egyetem
🇭🇺Budapest, Hungary
Local Institution - 0433
🇮🇳New Delhi, Delhi, India
Rajiv Gandhi Cancer Institute And Research Centre
🇮🇳New Delhi, Delhi, India
Local Institution - 0429
🇮🇳Srinagar, Jammu And Kashmir, India
KLES Dr. Prabhakar Kore Hospital & M.R.C
🇮🇳Belagavi, Karnataka, India
Local Institution - 0430
🇮🇳Kochi, Kerala, India
Local Institution - 0154
🇮🇳Mumbai, Maharashtra, India
Narayana Superspecialty Hospital
🇮🇳Howrah, West Bengal, India
Local Institution - 0410
🇮🇳New Town, West Bengal, India
Local Institution - 0495
🇮🇹Ravenna, Emilia-Romagna, Italy
Local Institution - 0493
🇮🇹Roma, Lazio, Italy
Local Institution - 0494
🇮🇹Palermo, Sicilia, Italy
Local Institution - 0496
🇮🇹Novara, Italy
Local Institution - 0276
🇯🇵Anjo, Aichi, Japan
Nagoya University Hospital
🇯🇵Nagoya, Aichi, Japan
National Cancer Center Hospital East
🇯🇵Kashiwa, Chiba, Japan
University of Fukui Hospital
🇯🇵Eiheiji-cho,Yoshida-gun, Fukui, Japan
Ogaki Municipal Hospital
🇯🇵Ogaki, Gifu, Japan
Hokkaido University Hospital
🇯🇵Sapporo, Hokkaido, Japan
Aiiku Hospital
🇯🇵Sapporo, Hokkaido, Japan
Hyogo Prefectural Amagasaki General Medical Center
🇯🇵Amagasaki, Hyogo, Japan
Japanease Red Cross Society Himeji Hospital
🇯🇵Himeji, Hyogo, Japan
Ishikawa Prefectural Central Hospital
🇯🇵Kanazawa, Ishikawa, Japan
Iwate Prefectural Central Hospital
🇯🇵Morioka, Iwate, Japan
Tokai University Hospital
🇯🇵Isehara, Kanagawa, Japan
Yokohama Municipal Citizens Hospital
🇯🇵Yokohama, Kanagawa, Japan
Tohoku University Hospital
🇯🇵Sendai-shi, Miyagi, Japan
Kindai University Hospital- Osakasayama Campus
🇯🇵Osaka-sayama, Osaka, Japan
Saitama Medical University International Medical Center
🇯🇵Hidaka, Saitama, Japan
Shizuoka Cancer Center
🇯🇵Nagaizumi-cho,Sunto-gun, Shizuoka, Japan
Juntendo University Hospital
🇯🇵Bunkyo-ku, Tokyo, Japan
Nihon University Itabashi Hospital
🇯🇵Itabashiku, Tokyo, Japan
University of Yamanashi Hospital
🇯🇵Chuo, Yamanashi, Japan
National Hospital Organization Kyushu Medical Center
🇯🇵Fukuoka, Japan
National Hospital Organization Kyushu Cancer Center
🇯🇵Fukuoka, Japan
Kyushu University Hospital
🇯🇵Fukuoka, Japan
Hiroshima University Hospital
🇯🇵Hiroshima, Japan
National Hospital Organization Kumamoto Medical Center
🇯🇵Kumamoto, Japan
Local Institution - 0215
🇯🇵Kyoto, Japan
Okayama University Hospital
🇯🇵Okayama, Japan
Osaka Red Cross Hospital
🇯🇵Osaka, Japan
Osaka Metropolitan University Hospital
🇯🇵Osaka, Japan
Yamagata University Hospital
🇯🇵Yamagata, Japan
National Cancer Center
🇰🇷Goyang-si, Kyǒnggi-do, Korea, Republic of
Local Institution - 0117
🇰🇷Seongnam, Kyǒnggi-do, Korea, Republic of
Seoul National University Bundang Hospital
🇰🇷Seongnam, Kyǒnggi-do, Korea, Republic of
Ajou University Hospital
🇰🇷Suwon-si, Kyǒnggi-do, Korea, Republic of
Dong-A University Hospital
🇰🇷Busan, Pusan-Kwangyǒkshi, Korea, Republic of
Pusan National University Hospital
🇰🇷Busan, Pusan-Kwangyǒkshi, Korea, Republic of
Kosin University Gospel Hospital
🇰🇷Busan, Pusan-Kwangyǒkshi, Korea, Republic of
Korea University Anam Hospital
🇰🇷Seoul, Seoul-teukbyeolsi [Seoul], Korea, Republic of
Seoul National University Hospital
🇰🇷Seoul, Seoul-teukbyeolsi [Seoul], Korea, Republic of
Local Institution - 0100
🇰🇷Seoul, Seoul-teukbyeolsi [Seoul], Korea, Republic of
Samsung Medical Center
🇰🇷Seoul, Seoul-teukbyeolsi [Seoul], Korea, Republic of
Local Institution - 0070
🇰🇷Seoul, Seoul-teukbyeolsi [Seoul], Korea, Republic of
The Catholic University of Korea, Yeouido St. Mary's Hospital
🇰🇷Seoul, Seoul-teukbyeolsi [Seoul], Korea, Republic of
Local Institution - 0442
🇰🇷Daegu, Taegu-Kwangyǒkshi, Korea, Republic of
Kyungpook National University Chilgok Hospital
🇰🇷Deagu, Taegu-Kwangyǒkshi, Korea, Republic of
Local Institution - 0116
🇰🇷Deagu, Taegu-Kwangyǒkshi, Korea, Republic of
Local Institution - 0455
🇰🇷Seongnam, Korea, Republic of
Hospital Pulau Pinang
🇲🇾George Town, Pulau Pinang, Malaysia
Sarawak General Hospital
🇲🇾Kuching, Sarawak, Malaysia
Hospital Ampang
🇲🇾Ampang, Selangor, Malaysia
Local Institution - 0453
🇲🇾Lembah Pantai, Wilayah Persekutuan Kuala Lumpur, Malaysia
Health Pharma Professional Research S.A. de C.V:
🇲🇽Ciudad de México, DIF, Mexico
Instituto Nacional de Ciencias Medicas y Nutricion Salvador Zubiran
🇲🇽Mexico City, DIF, Mexico
Local Institution - 0126
🇲🇽Cdmx, Distrito Federal, Mexico
Local Institution - 0128
🇲🇽México, Distrito Federal, Mexico
Local Institution - 0448
🇲🇽Guadalajara, Jalisco, Mexico
Centro de Investigacion Clinica Chapultepec
🇲🇽Morelia, Michoacán, Mexico
Hospital Universitario "Dr. Jose Eleuterio Gonzalez"
🇲🇽Monterrey, Nuevo León, Mexico
Centro de Investigacion Clinica de Oaxaca
🇲🇽Oaxaca de Juarez, Oaxaca, Mexico
Local Institution - 0444
🇲🇽Hermosillo, Sonora, Mexico
Local Institution - 0463
🇲🇽Hermosillo, Sonora, Mexico
Local Institution - 0123
🇲🇽Huixquilucan, Mexico
Unidad Médica Onco-hematológica
🇲🇽Puebla, Mexico
Leids Universitair Medisch Centrum
🇳🇱Leiden, Zuid-Holland, Netherlands
University Medical Center Groningen
🇳🇱Groningen, Netherlands
Dunedin Hospital
🇳🇿Dunedin, Otago, New Zealand
Local Institution - 0366
🇳🇿Hamilton, Waikato, New Zealand
Pratia MCM Krakow
🇵🇱Kraków, Małopolskie, Poland
Auckland City Hospital
🇳🇿Auckland, New Zealand
Oslo universitetssykehus, Radiumhospitalet
🇳🇴Oslo, Norway
Szpital Uniwersytecki Nr 2 im. dr J. Biziela w Bydgoszczy
🇵🇱Bydgoszcz, Kujawsko-pomorskie, Poland
Centrum Onkologii Ziemi Lubelskiej
🇵🇱Lublin, Lubelskie, Poland
Narodowy Instytut Onkologii im. Marii Sklodowskiej-Curie - Panstwowy Instytut Badawczy w Warszawie
🇵🇱Warszawa, Mazowieckie, Poland
Aidport
🇵🇱Skorzewo, Wielkopolskie, Poland
Local Institution - 0330
🇵🇱Katowice, Śląskie, Poland
Hospital da Luz Lisboa
🇵🇹Lisboa, Portugal
Instituto Português de Oncologia do Porto Francisco Gentil, EPE
🇵🇹Porto, Portugal
Pan American Center for Oncology Trials - Ciudadela
🇵🇷San Juan, Puerto Rico
Fundeni Clinical Institute
🇷🇴Bucuresti, București, Romania
Local Institution - 0375
🇷🇴Bucuresti, București, Romania
Spital Clinic Judetean de Urgenta Tg.Mures
🇷🇴Tg.Mures, Mureș, Romania
Sc Onco Card Srl
🇷🇴Brasov, Romania
Affidea Fundeni
🇷🇴București, Romania
Spitalul Clinic Colțea
🇷🇴București, Romania
Spitalul Universitar de Urgență București
🇷🇴București, Romania
Institutul Oncologic Cluj
🇷🇴Cluj, Romania
Institutul Regional de Oncologie
🇷🇴Iași, Romania
Spitalul Clinic Județean de Urgență Sibiu
🇷🇴Sibiu, Romania
Local Institution - 0445
🇸🇦Riyadh, Ar Riyāḑ, Saudi Arabia
King Fahad Specialist Hospital - Dammam
🇸🇦Dammam, Ash Sharqīyah, Saudi Arabia
Local Institution - 0438
🇸🇦Jeddah, Saudi Arabia
Local Institution - 0416
🇸🇦Riyadh, Saudi Arabia
National Cancer Centre Singapore
🇸🇬Singapore, Central Singapore, Singapore
Local Institution - 0355
🇸🇰Banska Bystrica, Banskobystrický Kraj, Slovakia
Local Institution - 0204
🇸🇰Bratislava, Slovakia
CHUAC-Complejo Hospitalario Universitario A Coruña
🇪🇸A Coruña, A Coruña [La Coruña], Spain
Institut Catalan d Oncologia (ICO) - Badalona
🇪🇸Badalona, Barcelona [Barcelona], Spain
Institut Català d'Oncologia - L'Hospitalet
🇪🇸L'Hospitalet Del Llobregat, Barcelona [Barcelona], Spain
OSI Ezkerraldea-Enkarterri-Cruces - Hospital Universitario Cruces
🇪🇸Barakaldo, Bizkaia, Spain
Hospital Universitario Nuestra Señora de Candelaria
🇪🇸Santa Cruz de Tenerife, Canarias, Spain
Hospital Universitario Donostia
🇪🇸San Sebastian, Gipuzkoa, Spain
Hospital Universitario Puerta de Hierro Majadahonda
🇪🇸Majadahonda, Madrid, Comunidad De, Spain
Hospital Clínico Universitario Virgen de la Arrixaca
🇪🇸El Palmar, Murcia, Murcia, Región De, Spain
Hospital Universitario Virgen de la Victoria
🇪🇸Malaga, Málaga, Spain
Hospital San Pedro de Alcantara
🇪🇸Cáceres, Spain
Hospital La Princesa
🇪🇸Madrid, Spain
Hospital General Universitario Gregorio Marañon
🇪🇸Madrid, Spain
Hospital Universitario Fundación Jiménez Díaz
🇪🇸Madrid, Spain
Hospital Universitario de Salamanca - Complejo Asistencial Universitario de Salamanca
🇪🇸Salamanca, Spain
Hospital Universitario Virgen Del Rocio
🇪🇸Sevilla, Spain
Skånes Universitetssjukhus Lund
🇸🇪Lund, Skåne Län [se-12], Sweden
Karolinska Universitetssjukhuset Solna
🇸🇪Solna, Stockholms Län [se-01], Sweden
Akademiska sjukhuset
🇸🇪Uppsala, Uppsala Län [se-03], Sweden
Local Institution - 0278
🇸🇪Linköping, Östergötlands Län [se-05], Sweden
Chang Gung Memorial Hospital- Chiayi
🇨🇳Chiayi City, Chiayi, Taiwan
Chi Mei Medical Center
🇨🇳Tainan City, Tainan, Taiwan
Chang Gung Memorial Hospital at Kaohsiung
🇨🇳Kaohsiung, Taiwan
China Medical University Hospital
🇨🇳Taichung, Taiwan
Taichung Veterans General Hospital
🇨🇳Taichung, Taiwan
National Taiwan University Hospital
🇨🇳Taipei, Taiwan
Taipei Veterans General Hospital
🇨🇳Taipei, Taiwan
Koo Foundation Sun Yat-Sen Cancer Center
🇨🇳Taipei, Taiwan
Chang Gung Medical Foundation-Linkou Branch
🇨🇳Taoyuan, Taiwan
Chulalongkorn University
🇹🇭Bangkok, Krung Thep Maha Nakhon, Thailand
Local Institution - 0473
🇹🇭Bangkok, Krung Thep Maha Nakhon, Thailand
Faculty of Medicine Siriraj Hospital
🇹🇭Bangkok, Krung Thep Maha Nakhon, Thailand
Maharaj Nakorn Chiang Mai Hospital
🇹🇭Chiang Mai, Thailand
Ankara University Health Practice and Research Hospitals
🇹🇷Ankara, Turkey
Gazi University Health Research and Application Center Gazi Hospital
🇹🇷Ankara, Turkey
Local Institution - 0422
🇹🇷Ankara, Turkey
Dr. Abdurrahman Yurtaslan Ankara Onkoloji Egitim ve Arastırma Hastanesi
🇹🇷Ankara, Turkey
Ege Universitesi Hastanesi
🇹🇷İzmir, Turkey
VM Medical Park Mersin Hastanesi
🇹🇷Mersin, Turkey
Ondokuz Mayıs Universitesi
🇹🇷Samsun, Turkey
Karadeniz Teknik Universitesi Tip Fakultesi
🇹🇷Trabzon, Turkey