An in vitro investigation of coagulation effects of exogenous sugammadex using thromboelastography in orthopaedic surgical patients .

Not Applicable

• Conditions: Coagulation effects of sugammadex

• Registration Number: JPRN-UMIN000029081
• Lead Sponsor: Korea University Guro Hospital Department of Anesthesiology and Pain Medicine

Brief Summary

Increased sugammadex concentrations were significantly associated with reduced coagulation, as evidenced by the increases in reaction time (r), coagulation time, and time to maximum rate of thrombus generation (TMRTG), and the decreases in the angle, maximum amplitude, and maximum rate of thrombus generation. Compared with the control, the median percentage change (interquartile range) in the TEG values of the samples with the highest exogenous sugammadex concentration was the greatest for r, 53% (26%, 67.3%), and TMRTG, 48% (26%, 59%).

Detailed Description

Not available

Study Timeline

• Results First Posted: 1900-01-01
• Study Start: 2017-09-11
• Study Completion: 2017-10-01
• Last Update Posted: 17 October 2023

Recruitment & Eligibility

• Status: Complete: follow-up complete
• Sex: All
• Target Recruitment: 15

Inclusion Criteria

Not provided

Exclusion Criteria

Patients taking aspirin or oral anticoagulant within 14 days Platelet<100,000, PT INR>1.5, or aPTT>50 sec Pregnant woman Liver disease or renal disease Surgical history within 30 days

Study & Design

• Study Type: Observational
• Study Design: Not specified

Primary Outcome Measures

Name	Time	Method
Thromboelastography parameters for citrated whole blood and citrated whole blood with exogenous sugammadex

Secondary Outcome Measures

Name	Time	Method
Association between percent change of thromboelastography parameters and sugammadex concentration