Post-Reperfusion Pathophysiology in Acute Ischemic Stroke Part 2

Not Applicable

Conditions: stroke
Stroke - Ischaemic

Registration Number: ACTRN12624000630516

Lead Sponsor: Melbourne Health

Brief Summary: Not available

Detailed Description: Not available

Recruitment & Eligibility

Status: ot yet recruiting

Sex: All

Target Recruitment: 250

Inclusion Criteria

Adult patients (>18 years-old) presenting for or receiving reperfusion therapies (e.g. thrombectomy) for acute ischaemic stroke with anterior circulation large vessel occlusion.

Exclusion Criteria

Exclusions include inability to give informed consent, contraindications to MRI study (eg. metallic foreign bodies in situ, claustrophobia, pregnancy), medical instability, terminal illness with expected survival less than 1 year.
Specific MRI sequences involving Gadolinum will be omitted for patients with significant renal impairment (eGFR <30 ml/min) as per standard practice for the studies.

Study & Design

Study Type: Observational

Study Design: Not specified

Primary Outcome Measures

Name	Time	Method
MRI perfusion metrics assessed as composite primary outcome (e.g. Cerebral Blood Volume, Cerebral Blood Flow, Blood Brain Barrier Permeability)[DSC-PWI MRI Immediately post-treatment, 24-48 hrs, 3 months]

Secondary Outcome Measures

Name	Time	Method
Modified Rankin Scale[Clinical assessment using the modified Rankin Scale by certified investigators 3-month post-treatment];Multimodal MRI metrics - Diffusion, QSM as composite secondary outcome[MRI Immediately post-treatment, 24-48 hrs, 3 months];Blood biomarkers of stroke-related pathology as a composite secondary outcome (e.g. IL6, TNF)[serum samples immediately pre and post-treatment]