The Vascularity Changes of Scars With Laser Therapy

Not Applicable

Completed

• Conditions: Hypertrophic Scar
• Interventions: Other: standardized care; Device: pulsed dye laser

• Registration Number: NCT03986346
• Lead Sponsor: The Hong Kong Polytechnic University

Brief Summary

The purpose of this study is to explore the effects of pulsed dye laser on managing scar vascularity and thickness.

Detailed Description

The pulsed dye laser is increasingly used in clinical settings to manage scars and shows promising outcomes.The pulsed dye laser targets at micro-vascular structures in scar tissues. This study aims to explore the vascularity changes in scars with pulsed dye laser during the scar formation process.

Study Timeline

• Status Verified: 2019-05
• Study First Submitted: 2019-05-24
• Study Start: 2019-05-31
• Study First Submitted QC: 2019-06-13
• Study First Posted: 2019-06-14
• Primary Completion: 2020-02-27
• Study Completion: 2020-02-27
• Last Update Submitted: 2020-03-06
• Last Update Posted: 2020-03-10

Recruitment & Eligibility

• Status: COMPLETED
• Sex: All
• Target Recruitment: 45

Inclusion Criteria

• scars caused by burn injury or related trauma;
• wound healing days over 3 weeks;
• days post injury less than 1 year;
• ability and willingness to comply with all the treatment and assessment procedures.

Exclusion Criteria

• history of steroid injection or graft surgery;
• history of keloid scarring;
• open wound or active infection;
• conditions that affect wound healing, such as diabetes mellitus.

Study & Design

• Study Type: INTERVENTIONAL
• Study Design: PARALLEL

Arm && Interventions

Group	Intervention	Description
Control group	standardized care	Participants in this group receive standardized care.
Laser group	pulsed dye laser	Participants in this group receive pulsed dye laser to treat the scar.
Laser group	standardized care	Participants in this group receive pulsed dye laser to treat the scar.

Primary Outcome Measures

Name	Time	Method
scar thickness	3 months	Ultrasound measures scar thickness.
scar erythema	3 months	Dermoscopy captures the scar photo and measures degrees of scar erythema.
scar blood flow	3 months	Ultrasound measures blood flow in scar tissues

Secondary Outcome Measures

Name	Time	Method
patient and observer scar assessment scale (POSAS)	3 months	The POSAS measures scar vascularity, pigmentation, pigmentation, thickness, relief, pliability and surface area. Every parameter ranges from 1 to 10, and higher score indicates worse scar performance in that parameter. The total score of POSAS is calculated by summing all the parameters' scores.

Trial Locations

Locations (2)

Prince of Wales Hospital; 🇭🇰 Hong Kong, Hong Kong

Southwest Hospital; 🇨🇳 Chongqing, China