What's the Role of Brain-derived Neurotrophic Factor in the Relationship Between Executive Function and Physical Fitness/Training in Typically Developing Children? A Randomized Controlled Study
试验速览
- 阶段
- 不适用
- 状态
- 已完成
- 入组人数
- 52
- 主要终点
- Change from baseline after 9 weeks in concentration of serum brain-derived neurotropic factor in blood sample.
研究概览
简要总结
This doctoral thesis has the aim to identify the role of Brain-derived neurotropic factor in the relationship between physical fitness/activity and executive functions in typically developing children and children with Autism Spectrum Disorder, Development Coordination Disorder , Attention Hyperactive Disorder.
详细描述
Nowadays children are getting more inactive and participate less in sports or daily physical activity. Previous studies have shown that a good physical fitness is associated with improved cognitive functions. While being physical active, physiological changes take places in the brain. Brain-derived neurotropic factor is one of the neurotropins that plays a crucial role in this process. Executive functions are cognitive processes that are responsible for organizing and controlling goal-directed actions. These functions are developing during childhood and play an important role in daily- and school functioning.
This doctoral thesis has the aim to identify the role of Brain-derived neurotropic factor in the relationship between physical fitness/activity and executive functions in children.
In a first trail the effect of physical fitness and physical training on executive functioning and levels of Brain-derived neurotropic factor will be studied.
In a second trail the research question is expanded by investigating the same relations in children with Autism Spectrum Disorder, Development Coordination Disorder , Attention Hyperactive Disorder.
Protocol trail 1: The included (typically developing) children will be randomized and stratified for level of physical fitness into 2 groups: the intervention group and the control group. The intervention group will receive physical activity training 2 times a week during 8 weeks. The control group will receive no additional training. At the beginning and the end of the training period both the intervention and control group will be tested for physical fitness and level of executive functioning.
研究设计
- 研究类型
- Interventional
- 分配方式
- Randomized
- 干预模型
- Parallel
- 主要目的
- Basic Science
- 盲法
- Single (Outcomes Assessor)
入排标准
- 年龄范围
- 8 Years 至 10 Years（Child）
- 性别
- All
- 接受健康志愿者
- 是
入选标准
- •typically developing children
排除标准
- •children with: executive function-, neurological- or cognitive disorders
- •Inclusion criteria:
- •typically developing children (control)
- •children with Developmental Coordination disorder, Attention deficit disorder or Autism Spectrum disorder
- •Exclusion criteria:
- •Children with neurological- or cognitive disorders
结局指标
主要结局
Change from baseline after 9 weeks in concentration of serum brain-derived neurotropic factor in blood sample.
时间窗: Baseline and change from baseline 9 weeks later.
Measurement of serum Brain-derived neurotropic factor true blood samples.
Change from Baseline after acute physical activity in concentration of serum brain-derived neurotropic factor in blood sample
时间窗: Baseline and change from baseline after 30 minutes of training.
Measurement of serum Brain-derived neurotropic factor true blood samples.
次要结局
- Change of baseline after 9 weeks in Maximal heart rate during exertion test.(Baseline and change of baseline 9 week later.)
- Change of baseline after 9 weeks in Maximal Oxygen Uptake during exertion test.(Baseline and change of baseline 9 week later.)
- Change from Baseline after acute physical activity on Executive functioning test battery.(Baseline and change of baseline after 30 minutes of physical activity.)
- Change of baseline after 9 weeks in Amount of daily physical activity (hours/week)(Baseline and change from baseline 9 weeks later.)
- Change from Baseline after 9 weeks on Executive functioning test battery.(Baseline and change of baseline 9 weeks later.)