Investigation of the effects of anaesthetic choice on ventilation-perfusion scatter and lung gas exchange.

Phase 4

• Conditions: Impaired lung function under anaesthesia; Anaesthesiology - Anaesthetics; Respiratory - Normal development and function of the respiratory system

• Registration Number: ACTRN12614000226606
• Lead Sponsor: Austin Health

Brief Summary

Not available

Detailed Description

Not available

Study Timeline

• Results First Posted: 1900-01-01
• Study Start: 2014-03-04
• Last Update Posted: 13 January 2020

Recruitment & Eligibility

• Status: ot yet recruiting
• Sex: All
• Target Recruitment: 24

Inclusion Criteria

Patients undergoing general anaesthesia for surgery requiring relacant GA with an arterial line for cardiovascular monitoring.

Exclusion Criteria

Severe impairment of lung function. (FEV1 or FVC less than 30% predicted), or morbid obesity (Body mass index (BMI) greater than 40 kg/m2)

Study & Design

• Study Type: Interventional
• Study Design: Not specified

Primary Outcome Measures

Name	Time	Method
Change in ventilation-perfusion scatter in the lung indexed by the log standard deviation of the distribution of ventilation and blood flow (d log SD) measured using the Multiple Inert Gas Elimination Technique (MIGET).[d log SD between measurement made pre-induction of anaesthesia to 2 hours after induction.]

Secondary Outcome Measures

Name	Time	Method
Blood gas indices of ventilation-perfusion (V/Q) scatter: PaO2, P(A-a)O2, P(A-a)CO2, shunt fraction and deadspace fraction.[Change from measurement made pre-induction of anaesthesia to 2 hours after induction.]