VIsual Cerebral ConnecTivity On Functional Magnetic Resonance Imaging in Patients With Hereditary REtinal Dystrophies
试验速览
- 阶段
- 不适用
- 状态
- 招募中
- 入组人数
- 200
- 试验地点
- 2
- 主要终点
- Localization and characterization of neural networks
研究概览
简要总结
The Rothschild Foundation A Hospital follows a cohort of approximately 300 patients with hereditary retinal dystrophy. These patients are followed in ophthalmology consultation every year. In order to plan the MRI on the day of the annual consultation and to avoid additional travel for patients, patients will be informed of the study before the consultation (transmission of an information letter and the information note from study). If patients agree to participate in the study, rMRI will be scheduled. During the follow-up ophthalmologic consultation, after checking the inclusion and non-inclusion criteria, the study information will be repeated, and patients who still agree to participate will sign the study consent.
研究设计
- 研究类型
- Observational
- 观察模型
- Cohort
- 时间视角
- Prospective
入排标准
- 年龄范围
- 18 Years 至 —（Adult, Older Adult）
- 性别
- All
- 接受健康志愿者
- 否
入选标准
- •Patient over 18 years old
- •Diagnostic clinique de dystrophie rétinienne héréditaire ou maculopathie héréditaire, syndromique ou non syndromique
- •Artificial vision treatment such as a retinal implant, or optogenetics scheduled in the next 6 months
- •Express consent to participate in the study
- •Affiliate or beneficiary of a social security scheme
排除标准
- •Patient benefiting from a legal protection measure
- •Pregnant or breastfeeding woman
- •Contraindication to MRI (claustrophobia, implanted equipment such as pacemaker).
- •Other additional ocular pathology that can significantly affect vision
- •Recent eye surgery less than 3 months old
结局指标
主要结局
Localization and characterization of neural networks
时间窗: baseline
neuronal networks description using rest and morphological functionnal MRIs
Evolution of neuronal networks after retinal implantation
时间窗: baseline
neuronal networks description using rest and morphological functionnal MRIs
次要结局
未报告次要终点