VIsual Cerebral ConnecTivity On Functional Magnetic Resonance Imaging in Patients With Hereditary REtinal Dystrophies
Overview
- Phase
- N/A
- Intervention
- Not specified
- Conditions
- Vision Functional Brain Networks in Patients With Hereditary Retinal Dystrophies
- Sponsor
- Fondation Ophtalmologique Adolphe de Rothschild
- Enrollment
- 200
- Locations
- 2
- Primary Endpoint
- Localization and characterization of neural networks
- Status
- Recruiting
- Last Updated
- 3 months ago
Overview
Brief Summary
The Rothschild Foundation A Hospital follows a cohort of approximately 300 patients with hereditary retinal dystrophy. These patients are followed in ophthalmology consultation every year. In order to plan the MRI on the day of the annual consultation and to avoid additional travel for patients, patients will be informed of the study before the consultation (transmission of an information letter and the information note from study). If patients agree to participate in the study, rMRI will be scheduled. During the follow-up ophthalmologic consultation, after checking the inclusion and non-inclusion criteria, the study information will be repeated, and patients who still agree to participate will sign the study consent.
Investigators
Eligibility Criteria
Inclusion Criteria
- •Patient over 18 years old
- •Diagnostic clinique de dystrophie rétinienne héréditaire ou maculopathie héréditaire, syndromique ou non syndromique
- •Artificial vision treatment such as a retinal implant, or optogenetics scheduled in the next 6 months
- •Express consent to participate in the study
- •Affiliate or beneficiary of a social security scheme
Exclusion Criteria
- •Patient benefiting from a legal protection measure
- •Pregnant or breastfeeding woman
- •Contraindication to MRI (claustrophobia, implanted equipment such as pacemaker).
- •Other additional ocular pathology that can significantly affect vision
- •Recent eye surgery less than 3 months old
Outcomes
Primary Outcomes
Localization and characterization of neural networks
Time Frame: baseline
neuronal networks description using rest and morphological functionnal MRIs
Evolution of neuronal networks after retinal implantation
Time Frame: baseline
neuronal networks description using rest and morphological functionnal MRIs