Functional Neuroimaging and Genetic Vulnerability to Suicidal Behavior

Not Applicable

Terminated

• Conditions: Suicidal Behavior
• Interventions: Device: Magnetic resonance imaging (MRI)

• Registration Number: NCT02960191
• Lead Sponsor: University Hospital, Montpellier

Brief Summary

The main objective is to highlight, by functional imaging (MRI) dysfunctional brain regions associated with vulnerability to suicidal behavior.

Detailed Description

Not available

Study Timeline

• Study Start: 2008-12
• Primary Completion: 2012-03
• Study Completion: 2012-03
• Study First Submitted: 2016-08-30
• Status Verified: 2016-11
• Study First Submitted QC: 2016-11-07
• Last Update Submitted: 2016-11-07
• Study First Posted: 2016-11-09
• Last Update Posted: 2016-11-09

Recruitment & Eligibility

• Status: TERMINATED
• Sex: Male
• Target Recruitment: 95

Inclusion Criteria

• right-handed
• arm suicidal : Personal history of unipolar depressive disorder or bipolar disorder and having realized in his life at least one suicide attempt
• arm emotional Witnesses : Personal history of unipolar depressive disorder or bipolar disorder and have never done in his life attempted suicide
• arm healthy Witnesses : any current or past personal history of psychiatric disorders of Axis I and have never done in his life attempted suicide

Exclusion Criteria

• Cons-indications to the use of MRI
• Existence of a past history of head trauma with loss of consciousness or neurological brain disorder or secondary neurological suffering suicidal gesture.

Study & Design

• Study Type: INTERVENTIONAL
• Study Design: PARALLEL

Arm && Interventions

Group	Intervention	Description
emotional witness	Magnetic resonance imaging (MRI)	subject having had a personal history of unipolar or bipolar depressive disorder and who have never done in his life attempted suicide
patient suicide	Magnetic resonance imaging (MRI)	subject having had a personal history of unipolar or bipolar depressive disorder and having realized in his life at least one suicide attempt
healthy volunteers	Magnetic resonance imaging (MRI)	subject with no current or past personal history of psychiatric disorders and about never having carried out suicide attempt

Primary Outcome Measures

Name	Time	Method
MRI variations	at day 0	activation of specific brain areas during the procurement of a test decision

Trial Locations

Locations (1)

University Hospital of Montpellier; 🇫🇷 Montpellier, France