Comparing the effect of Metformin and Megestrol acetate on endometrial histology in patients with disordered proliferative or hyperplastic endometrium. A RCT
Phase 2
- Conditions
- Patients with abnormal uterine bleeding and have disordered proliferative or hyperplastic endometrium with or without atypia.Endometrial glandular hyperplasia
- Registration Number
- IRCT201205265283N4
- Lead Sponsor
- Women's Reproductive Health Research Center, Tabriz University of Medical Sciences
- Brief Summary
Not available
- Detailed Description
Not available
Recruitment & Eligibility
- Status
- Complete
- Sex
- Female
- Target Recruitment
- 90
Inclusion Criteria
Patients with abnormal uterine bleeding and havingdisordered proliferative or hyperplastic endometrium with or without atypia. Consent to participate.
Exclusion criteria:
Patients who have allergy to metformin, Patients with renal failure, nausea, vomiting, anorexia, anemia, cutaneous lesionsor not satisfied to participate in the study.
Exclusion Criteria
Not provided
Study & Design
- Study Type
- interventional
- Study Design
- Not specified
- Primary Outcome Measures
Name Time Method Endometrialpathology. Timepoint: before surgery. Method of measurement: Pathologic assessment.;Endometrial Histologic type. Timepoint: Three months after medical therapy. Method of measurement: Microscopic assessment.
- Secondary Outcome Measures
Name Time Method