NCT05749198已完成不适用
Non-invasive Assessment of Portal Hypertension Using Quantitative Magnetic Resonance Imaging
适应症
试验速览
- 阶段
- 不适用
- 状态
- 已完成
- 入组人数
- 47
- 试验地点
- 1
- 主要终点
- Change of liver stiffness and spleen stiffness by MRE
研究概览
简要总结
This prospective study was conducted in a tertiary university hospital. The investigators researched the correlation between MRE-assessed stiffness of the liver and spleen and the Hepatic venous pressure gradient (HVPG) values. Furthermore, the investigator evaluated whether MRE-assessed stiffness reflected changes in portal hypertension (PH) after administering non-selective beta-blockers (NSBBs).
研究设计
- 研究类型
- Observational
- 观察模型
- Cohort
- 时间视角
- Prospective
入排标准
- 年龄范围
- 18 Years 至 —（Adult, Older Adult）
- 性别
- All
- 接受健康志愿者
- 否
入选标准
- •diagnosed liver cirrhosis
- •requiring prophylactic treatment of esophageal varices
排除标准
- •the coexistence of hepatocellular carcinoma
- •refractory ascites who regularly underwent large-volume paracentesis
- •the use of selective beta-blocker or carvedilol therapy for at least 4 weeks
- •undergoing liver transplantation
- •contraindication with magnetic resonance imaging
结局指标
主要结局
Change of liver stiffness and spleen stiffness by MRE
时间窗: Change from baseline stiffness of MRE at 6 months
The change of portal pressure (HVPG) prior to and after treatment with NSBB
时间窗: Change from baseline and at 6 months
次要结局
未报告次要终点
研究者
Moon Young Kim
Professor
Yonsei University
研究点 (1)
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