NCT05749198
Completed
Not Applicable
Non-invasive Assessment of Portal Hypertension Using Quantitative Magnetic Resonance Imaging
Overview
- Phase
- Not Applicable
- Intervention
- Not specified
- Conditions
- Portal Hypertension
- Sponsor
- Yonsei University
- Enrollment
- 47
- Locations
- 1
- Primary Endpoint
- Change of liver stiffness and spleen stiffness by MRE
- Status
- Completed
- Last Updated
- 3 years ago
Overview
Brief Summary
This prospective study was conducted in a tertiary university hospital. The investigators researched the correlation between MRE-assessed stiffness of the liver and spleen and the Hepatic venous pressure gradient (HVPG) values. Furthermore, the investigator evaluated whether MRE-assessed stiffness reflected changes in portal hypertension (PH) after administering non-selective beta-blockers (NSBBs).
Investigators
Moon Young Kim
Professor
Yonsei University
Eligibility Criteria
Inclusion Criteria
- •diagnosed liver cirrhosis
- •requiring prophylactic treatment of esophageal varices
Exclusion Criteria
- •the coexistence of hepatocellular carcinoma
- •refractory ascites who regularly underwent large-volume paracentesis
- •the use of selective beta-blocker or carvedilol therapy for at least 4 weeks
- •undergoing liver transplantation
- •contraindication with magnetic resonance imaging
Outcomes
Primary Outcomes
Change of liver stiffness and spleen stiffness by MRE
Time Frame: Change from baseline stiffness of MRE at 6 months
The change of portal pressure (HVPG) prior to and after treatment with NSBB
Time Frame: Change from baseline and at 6 months
Study Sites (1)
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