In-Hospital Detection of Elevated Blood Pressure (INDEBP): Prevalence of New or Uncontrolled Hypertension and Safety of Postponement of Antihypertensive Treatment Adaption in Medical In-patients
Overview
- Phase
- Not Applicable
- Intervention
- Not specified
- Conditions
- Hypertension
- Sponsor
- Annina Vischer
- Enrollment
- 800
- Locations
- 1
- Primary Endpoint
- Prevalence of persisting new or uncontrolled arterial hypertension
- Status
- Not yet recruiting
- Last Updated
- 2 years ago
Overview
Brief Summary
The goal of this clinical trial is to analyse the prevalence of new or uncontrolled arterial hypertension (AHT) after hospital discharge of medical in-patients with elevated blood pressure (BP) values during hospitalisation.
The main questions it aims to answer are:
- Do elevated BP values during hospitalisation correspond to new or uncontrolled AHT after hospital discharge?
- Is it safe to postpone adaption of antihypertensive treatment until after proper evaluation of AHT after hospital discharge?
Participants will either be treated according to their physicians' decision or antihypertensive treatment adaptions will be postponed until after hospital discharge.
Investigators
Annina Vischer
Principle Investigator
University Hospital, Basel, Switzerland
Eligibility Criteria
Inclusion Criteria
- •Patient hospitalized on the internal medicine ward for non-cardiovascular causes, i.e. patients hospitalized for conditions, which are not acutely worsened by uncontrolled AHT
- •Asymptomatic elevated BP values (defined as 140-180 mmHg systolic and/or 90-110 mmHg diastolic) on at least 2 occasions
- •Ability to understand study procedures and to provide written informed consent
Exclusion Criteria
- •Hospitalization for any conditions which can be worsened by uncontrolled AHT:
- •Cerebrovascular events
- •Acute coronary syndrome
- •Acute or decompensated heart failure
- •Any condition preventing ABPM
- •Pregnant or lactating women
- •Failure to provide informed consent
Outcomes
Primary Outcomes
Prevalence of persisting new or uncontrolled arterial hypertension
Time Frame: 4 weeks after hospital discharge
Elevated blood pressure values in ambulatory blood pressure monitoring
Prevalence of a combined hypertensive complication endpoint
Time Frame: Until 4 weeks after hospital discharge
Consisting of intracerebral bleeding, ischemic stroke, myocardial infarction, cardiovascular death or cardiovascular re-hospitalization
Prevalence of a combined hypotensive complication endpoint
Time Frame: Until 4 weeks after hospital discharge
Consisting of falls, acute kidney injury, electrolyte disturbances, re-hospitalizations due to hypotension, or BP values on ABPM below the lower treatment limit
Secondary Outcomes
- Prevalence of re-hospitalization for any cause(Until 4 weeks after hospital discharge)
- Clinic blood pressure measurement in mmHg(At baseline)
- Research blood pressure measurement in mmHg(At baseline)
- Prevalence of previously unknown arterial hypertension(At baseline)
- Prevalence of female gender(At baseline)