In-Hospital Detection of Elevated Blood Pressure

Not Applicable

Not yet recruiting

• Conditions: Hypertension; Blood Pressure, High
• Interventions: Other: Postponement of antihypertensive treatment

• Registration Number: NCT06132451
• Lead Sponsor: Annina Vischer

Brief Summary

The goal of this clinical trial is to analyse the prevalence of new or uncontrolled arterial hypertension (AHT) after hospital discharge of medical in-patients with elevated blood pressure (BP) values during hospitalisation.

The main questions it aims to answer are:

* Do elevated BP values during hospitalisation correspond to new or uncontrolled AHT after hospital discharge?

* Is it safe to postpone adaption of antihypertensive treatment until after proper evaluation of AHT after hospital discharge?

Participants will either be treated according to their physicians' decision or antihypertensive treatment adaptions will be postponed until after hospital discharge.

Detailed Description

Not available

Study Timeline

• Status Verified: 2023-11
• Study First Submitted: 2023-11-05
• Study Start: 2023-11-07
• Study First Submitted QC: 2023-11-09
• Last Update Submitted: 2023-11-09
• Study First Posted: 2023-11-15
• Last Update Posted: 2023-11-15
• Primary Completion: 2024-12-31
• Study Completion: 2024-12-31

Recruitment & Eligibility

• Status: NOT_YET_RECRUITING
• Sex: All
• Target Recruitment: 800

Inclusion Criteria

• Patient hospitalized on the internal medicine ward for non-cardiovascular causes, i.e. patients hospitalized for conditions, which are not acutely worsened by uncontrolled AHT
• Asymptomatic elevated BP values (defined as 140-180 mmHg systolic and/or 90-110 mmHg diastolic) on at least 2 occasions
• Ability to understand study procedures and to provide written informed consent

Exclusion Criteria

• Hospitalization for any conditions which can be worsened by uncontrolled AHT:
• Cerebrovascular events
• Acute coronary syndrome
• Acute or decompensated heart failure
• Any condition preventing ABPM
• Pregnant or lactating women
• Failure to provide informed consent

Study & Design

• Study Type: INTERVENTIONAL
• Study Design: PARALLEL

Arm && Interventions

Group	Intervention	Description
Postponement of treatment arm	Postponement of antihypertensive treatment	Antihypertensive treatment adaptions will be postponed until after a 24h ambulatory blood pressure measurement (ABPM) 4 weeks after hospital discharge.

Primary Outcome Measures

Name	Time	Method
Prevalence of persisting new or uncontrolled arterial hypertension	4 weeks after hospital discharge	Elevated blood pressure values in ambulatory blood pressure monitoring
Prevalence of a combined hypertensive complication endpoint	Until 4 weeks after hospital discharge	Consisting of intracerebral bleeding, ischemic stroke, myocardial infarction, cardiovascular death or cardiovascular re-hospitalization
Prevalence of a combined hypotensive complication endpoint	Until 4 weeks after hospital discharge	Consisting of falls, acute kidney injury, electrolyte disturbances, re-hospitalizations due to hypotension, or BP values on ABPM below the lower treatment limit

Secondary Outcome Measures

Name	Time	Method
Prevalence of re-hospitalization for any cause	Until 4 weeks after hospital discharge	According to hospital documentation and patient interrogation
Clinic blood pressure measurement in mmHg	At baseline	Documented in the patient documentation
Research blood pressure measurement in mmHg	At baseline	Standardized blood pressure measurement taken by research staff
Prevalence of previously unknown arterial hypertension	At baseline	No previously documented diagnosis of arterial hypertension and no antihypertensive treatment
Prevalence of female gender	At baseline	As reported by participant

Trial Locations

Locations (1)

University Hospital Basel; 🇨🇭 Basel, Switzerland