Modeling of the Hemoglobin Drop in the Uncomplicated Postoperative Course

Completed

• Conditions: Surgery; Surgical Blood Loss; Perioperative/Postoperative Complications

• Registration Number: NCT03740438
• Lead Sponsor: Hospital Clinic of Barcelona

Brief Summary

transfusion-related decisions in the perioperative setting are often complex due to acute variations in the hemoglobin levels, which typically experience a progressive decrease within days. This process, commonly referred to as "hemoglobin drop" or "hemoglobin drift", has been observed to be highly variable among patients and reliant on several variables, such as the volemic status, fluid balance and blood loss. Although it has been investigated and some predictors have been identified, postoperative hemoglobin drop remains unpredictable and is not fully clarified. In consequence, hemoglobin levels' variations are frequently misunderstood, hindering the decision to transfuse.

Detailed Description

Not available

Study Timeline

• Study Start: 2018-09-01
• Study First Submitted: 2018-11-05
• Study First Submitted QC: 2018-11-11
• Study First Posted: 2018-11-14
• Primary Completion: 2023-09-01
• Study Completion: 2023-09-02
• Status Verified: 2024-10
• Last Update Submitted: 2024-10-27
• Last Update Posted: 2024-10-29

Recruitment & Eligibility

• Status: COMPLETED
• Sex: All
• Target Recruitment: 154

Inclusion Criteria

• Adult patients electively scheduled for laparoscopic urologic and gynecologic surgery.

Exclusion Criteria

• Suspected or confirmed coagulopathy (including current treatment with anticoagulants or antiplatelet agents).
• Requirement for surgical gauzes during surgery, including conversion to open surgical techniques.
• Transfusion of red blood cells (RBCs) or use of blood recovery systems during the perioperative period.
• Significant postoperative bleeding (> 50 ml in surgical drains, gross hematuria, or any other type of significant blood loss).
• Postoperative hemodynamic instability (defined as requirement of vasoactive drugs).
• Other major postoperative complications during the observable period.

Study & Design

• Study Type: OBSERVATIONAL
• Study Design: Not specified

Primary Outcome Measures

Name	Time	Method
Hemoglobin concentration	2-5 days	Patient´s hemoglobin concentration in the postoperative course (measured every 24 hours)

Trial Locations

Locations (1)

Hospital Clinic de Barcelona; 🇪🇸 Barcelona, Spain