Assessment of Platelet-dependent Thrombosis in Patients With Acute Coronary Syndromes Using an ex Vivo Arterial Injury Model
Overview
- Phase
- Not Applicable
- Intervention
- Not specified
- Conditions
- Type 2 Diabetes Mellitus
- Sponsor
- Newcastle-upon-Tyne Hospitals NHS Trust
- Enrollment
- 90
- Locations
- 1
- Primary Endpoint
- Thrombus area
- Status
- Completed
- Last Updated
- 10 years ago
Overview
Brief Summary
The purpose of this study is to assess platelet dependent thrombogenicity in patients after acute coronary syndrome using an ex vivo arterial injury model.
Detailed Description
Abnormal platelet activity seen in patients with Type2 Diabetes Mellitus (T2DM) may be an important contributor to their enhanced cardiovascular risk and higher rates of cardiovascular events following acute coronary syndrome, despite dual antiplatelet therapy with aspirin and clopidogrel. We have earlier demonstrated high thrombogenicity in individuals with T2DM and CAD in the absence of acute ischaemic events, despite therapeutic doses of aspirin.We hypothesise that patients with T2DM will have increased thrombogenicity after acute coronary syndrome despite optimal secondary prevention medication.Measuring ex vivo thrombus area using an arterial injury model simulates plaque rupture and reflects the summative effect of all haemostatic abnormalities. The thrombus area of patients with ACS and T2DM will be compared to the controls without T2DM.
Investigators
Eligibility Criteria
Inclusion Criteria
- •Acute coronary syndrome (WHO criteria) with raised cardiac troponin T
- •Aged 18-80 years
- •Stable Acute coronary syndrome
- •On aspirin and clopidogrel
- •Willing to participate in the study
Exclusion Criteria
- •Smoking (current smokers or smokers who quit in the last 6 months preceding recruitment)
- •Malignancy (any suspected or proven)
- •Haematological disorders (bleeding disorders)
- •Pre-menopausal women
- •Use of corticosteroids/other antithrombotic agents (warfarin)
- •Chronic liver disease
- •Unable to consent
Outcomes
Primary Outcomes
Thrombus area
Time Frame: Within 10 days after acute coronary syndrome
Secondary Outcomes
- Factors affecting thrombus area(Within ten days after acute coronary syndrome)