Effects of Respiratory Muscle Exercises on Glucose Tolerance in Healthy Adults

Not Applicable

Completed

• Conditions: Healthy Aging; Healthy Diet
• Interventions: Other: 5min respiratory muscle exercises; Other: 15min respiratory muscle exercises

• Registration Number: NCT04520763
• Lead Sponsor: Swiss Federal Institute of Technology

Brief Summary

To evaluate the acute effects of respiratory muscle exercises vs. a control intervention on blood glucose kinetics in healthy adults after an oral glucose tolerance test.

Detailed Description

Not available

Study Timeline

• Study First Submitted: 2020-08-17
• Study First Submitted QC: 2020-08-19
• Study Start: 2020-08-20
• Study First Posted: 2020-08-20
• Primary Completion: 2022-04-21
• Study Completion: 2022-04-21
• Status Verified: 2023-03
• Last Update Submitted: 2023-03-16
• Last Update Posted: 2023-03-17

Recruitment & Eligibility

• Status: COMPLETED
• Sex: All
• Target Recruitment: 42

Inclusion Criteria

• Age ≥18 years
• Healthy
• Non-smoking
• Body mass index (BMI): 18.5 - 29.9 kg∙m-2
• Normal lung function
• Willing to adhere to study rules

Exclusion Criteria

• Known or suspected non-compliance, drug or alcohol abuse
• Inability to follow the procedures of the study, e.g. due to language problems, psychological disorders, dementia, etc. of the participant
• Previous enrolment into the current study
• Intake of medications affecting metabolism, the cardiovascular or the respiratory system, or sleep
• Acute illness or chronic conditions of the gastrointestinal tract, and health conditions affecting metabolism, the cardiovascular or the respiratory system, or sleep
• Pregnancy, breastfeeding, or intention to become pregnant during the study

Study & Design

• Study Type: INTERVENTIONAL
• Study Design: CROSSOVER

Arm && Interventions

Group	Intervention	Description
Respiratory Muscle Exercises	15min respiratory muscle exercises	Two respiratory muscle exercises
Respiratory Muscle Exercises	5min respiratory muscle exercises	Two respiratory muscle exercises

Primary Outcome Measures

Name	Time	Method
Peak blood glucose concentration	throughout the study, an expected average of 2 weeks per participant	Peak blood glucose concentration will be determined in the three conditions (5min or 15min respiratory muscle exercises or control).
area under the glucose-time curve	throughout the study, an expected average of 2 weeks per participant	Area under the glucose-time curve will be determined in the three conditions (5min or 15min respiratory muscle exercises or control).

Trial Locations

Locations (1)

Exercise Physiology Lab, Institute of Human Movement Sciences and Sport, ETH Zurich; 🇨🇭 Zürich, ZH, Switzerland