Predicting Normal vs. Carrier Status in Euploid Embryos of Translocation Carriers

Completed

• Conditions: Balanced Chromosomal Translocation

• Registration Number: NCT02178865
• Lead Sponsor: Reproductive Medicine Associates of New Jersey

Brief Summary

The purpose of this study is to assess the accuracy of predicting the normal or carrier status of human embryos resulting from in vitro-fertilization (IVF) from patients carrying a balanced translocation.

Detailed Description

This study aims to evaluate the validity of using informative SNPs to distinguish balanced from normal embryos. This will involve acquiring material from families to set phase for informative SNPs, evaluation of existing and new embryo SNP array data, and follow up analysis of children born after applying the procedure.

Study Timeline

• Study Start: 2014-06
• Study First Submitted: 2014-06-26
• Study First Submitted QC: 2014-06-27
• Study First Posted: 2014-07-01
• Primary Completion: 2015-12
• Study Completion: 2017-02
• Status Verified: 2017-03
• Last Update Submitted: 2017-03-16
• Last Update Posted: 2017-03-17

Recruitment & Eligibility

• Status: COMPLETED
• Sex: All
• Target Recruitment: 11

Inclusion Criteria

• patients with balanced translocations who have undergone IVF

Exclusion Criteria

• those who do not wish to know their child(s) karyotype

Study & Design

• Study Type: OBSERVATIONAL
• Study Design: Not specified

Primary Outcome Measures

Name	Time	Method
Proportion of correct predictions of normal vs. balanced ploidy status as compared to conventional karyotype	up to 12 months once pregnant

Trial Locations

Locations (1)

Reproductive Medicine Associates of New Jersey; 🇺🇸 Basking Ridge, New Jersey, United States