Platelet Function Analysis in Head Trauma: ASA/CLOPIDOGREL
试验速览
- 阶段
- 不适用
- 状态
- 已完成
- 发起方
- 入组人数
- 97
- 试验地点
- 1
- 主要终点
- Platelet inhibition
研究概览
简要总结
The investigators are assessing the platelet function analysis of those who sustained significant head trauma while on aspirin or plavix and to assess if any qualitative difference is obtained if platelets are administered.
详细描述
The platelet function analyzer VerifyNow® P2Y12 uses ADP as agonists to induce platelet activation and ascertain the level of platelet function impaired by these medications. VerifyNow® Aspirin Assay utilizes arachidonic acid as the agonist to measure platelet function specifically along this pathway. Our research question for this study is as follows:
Does the administration of desmopressin (DDAVP) and/or the transfusion of platelets in patients with head trauma reverse the platelet inhibition caused by Aspirin and/or Plavix? The investigators hypothesize that with the administration of platelets and/or DDAVP that there is a reversal of the inhibition.
研究设计
- 研究类型
- Interventional
- 分配方式
- Non Randomized
- 干预模型
- Parallel
- 盲法
- None
入排标准
- 年龄范围
- 18 Years 至 —（Adult, Older Adult）
- 性别
- All
- 接受健康志愿者
- 否
入选标准
- •Age > 18yrs
- •Must be a trauma patient with blunt head trauma.
- •Must be on Aspirin and/or Plavix
- •Subject or Legally Authorized Representative (LAR) (per Heath and Safety Code, Sections 24170 to 24179.5) must sign study consent within 4 hours from the first blood draw. (If this criterion is not met the initial blood draw must be destroyed and NOT run for study results).
排除标准
- •Hemoglobin ≤ 10 GM/DL
- •Platelet Count ≤ 150 K/MCL
- •Pregnant Females
- •Subjects on Warfarin, Heparin or Enoxaparin
研究组 & 干预措施
Platelets/DDAVP
Fall on ASA/Plavix that sustained head trauma requiring administration of platelets and/or DDAVP
干预措施: Platelets (Biological)
Platelets/DDAVP
Fall on ASA/Plavix that sustained head trauma requiring administration of platelets and/or DDAVP
干预措施: DDAVP (Drug)
结局指标
主要结局
Platelet inhibition
时间窗: 8 hours
We are measuring platelet inhibition using the verify now platelet function analyzer
次要结局
未报告次要终点