NCT03209128终止不适用
Savings of Hippocampus and Amygdala by Archetherapy in Cerebral Prophylactic Irradiation in Patients With Limited and / or Extended, Responsive or Stable Small Cell Lung Cancer (SCLC)
Centre Francois Baclesse, Luxembourg1 个研究点 分布在 1 个国家目标入组 11 人开始时间: 2017年4月20日最近更新:
适应症
试验速览
- 阶段
- 不适用
- 状态
- 终止
- 发起方
- 入组人数
- 11
- 试验地点
- 1
- 主要终点
- Cognitive function
研究概览
简要总结
Hippocampus and amygdala are parts of the brain involved in the recognition of emotions, memories, memory, language ... It is therefore very important to protect them during irradiation of the brain.
The aim of this study is to evaluate cerebral irradiation with saving hippocampus and amygdala protects these brain functions in patients with small cell lung cancer (SCLC) Radiotherapy of the brain
研究设计
- 研究类型
- Observational
- 观察模型
- Cohort
- 时间视角
- Prospective
入排标准
- 年龄范围
- 18 Years 至 —（Adult, Older Adult）
- 性别
- All
- 接受健康志愿者
- 否
入选标准
- •Patients over 18 years of age
- •Patients with a limited SCLC demonstrated histologically responsive or stable to radiochemotherapy or patients with a histologically proven extended SCLC responding to chemotherapy.
- •WHO Performance Index 0-1 and / or Karnovsky Index> 70
- •Possibility of long-term monitoring
排除标准
- •Concomitant chemotherapy
- •Impossibility of performing an MRI or CT without injection
- •Presence of cerebral metastases
- •History of cerebral irradiation at any time
- •Patient suffering from severe collagenosis
- •Patient with cognitive disorders with MMSE score <24
结局指标
主要结局
Cognitive function
时间窗: until 18 months after inclusion of patient
Evaluate the cognitive function with Wechsler Memory Scale IV (WMS-IV) test
次要结局
- Appearance of brain metastases and their location(until 18 months after inclusion of patient)
- Secondary effects according the CTCAE v.4 criteria(until 18 months after inclusion of patient)
- Quality of life (QOL) of patients(until 18 months after inclusion of patient)
研究者
研究点 (1)
Loading locations...
相似试验
招募中
不适用
Amygdala Memory EnhancementBrain DiseasesMemory DisordersTraumatic Brain InjuryCognitive ImpairmentPost Traumatic Stress DisorderEpilepsyNCT05065450Washington University School of Medicine90
已完成
不适用
Hippocampal Metabolism and Function in Patients With Type 1 DiabetesDiabetes MellitusHypoglycemiaNCT01852968University of Minnesota57
招募中
不适用
Developing a biomarker for anxiety disordersPanicSimple PhobiaGeneralized AnxietySocial AnxietyPsychological DistressMental Health - AnxietyMental Health - Studies of normal psychology, cognitive function and behaviourMental Health - Other mental health disordersAnxietyACTRN12620001222932niversity of Otago300
进行中（未招募）
不适用
Patient-derived Stem Cell Models of Anorexia NervosaAnorexia NervosaNCT06259500Karolinska Institutet20
已完成
不适用
Representational Approach to Hippocampal Functions : a fMRI StudyMemory, EpisodicForm PerceptionNCT04562974University Hospital, Grenoble60