To study the effect of statins (atorvastatin) in reducing mortality in patients of sepsis in a medical emergency setting.
Phase 3
- Conditions
- Health Condition 1: R509- Fever, unspecified
- Registration Number
- CTRI/2024/01/061069
- Lead Sponsor
- POSTGRADUATE INSTITUTE OF MEDICAL EDUCATION AND RESEARCH CHANDIGARH
- Brief Summary
Not available
- Detailed Description
Not available
Recruitment & Eligibility
- Status
- Open to Recruitment
- Sex
- Not specified
- Target Recruitment
- 0
Inclusion Criteria
a) adults with age > 18 years
b) Patients getting admitted in medical emergency with sepsis, defined as
?Suspected or documented infection: patient having signs and symptoms of
infection, such as fever, leucocytosis, or localising signs (e.g.: pneumonia, urinary
tract infection, intraabdominal infection or skin and soft tissue infection).
? SOFA score of 2 or more
Exclusion Criteria
a) Pregnant females.
b) Patients of cardiovascular disease who are already on statins.
c) Patients with malignancy.
d) Patients with liver failure.
e) Patients with myopathy.
f) Age <18years.
g) Patients with trauma.
h) Surgical patients.
Study & Design
- Study Type
- Interventional
- Study Design
- Not specified
- Primary Outcome Measures
Name Time Method all cause mortalityTimepoint: 1month
- Secondary Outcome Measures
Name Time Method organ dysfunction, <br/ ><br>length of hospital stay <br/ ><br>effect on inflammatory markers <br/ ><br> <br/ ><br>Timepoint: 1 month