NCT00168194已完成不适用
Cellular Immune Responses to Hepatitis B Virus (HBV)- Longitudinal Follow up and Natural History
The Alfred1 个研究点 分布在 1 个国家目标入组 104 人开始时间: 2004年12月最近更新:
适应症
试验速览
- 阶段
- 不适用
- 状态
- 已完成
- 发起方
- 入组人数
- 104
- 试验地点
- 1
研究概览
简要总结
It remains unclear why some individuals are able to clear HBV from their bodies while in others HBV is a persistent infection. We plan to investigate this process by collecting blood and analysing how the patient's white blood cells respond to different pieces of the HBV virus. We will use new tools that can precisely tell us which component of the immune response may be different in individuals who are chronically infected with HBV and also in individuals who are also infected with HIV.
The primary aims are therefore:
- To characterize HBV-specific T cell responses in HBV chronic carriers, and identify novel immunogenic regions in both HLA-A2+ and non-HLA-A2+ individuals.
- To determine the effect of HIV infection on HBV-specific T-cell responses
研究设计
- 研究类型
- Observational
- 观察模型
- Cohort
- 时间视角
- Prospective
入排标准
- 年龄范围
- 18 Years 至 —（Adult, Older Adult）
- 性别
- All
- 接受健康志愿者
- 否
入选标准
- •There are two groups of patients in this study. Group A mono-infected with Hepatitis B, and those with co-infection HBV/HIV.
- •Group A inclusion criteria: (also split into 6 recruiting groups)
- •Acute hepatitis B
- •Chronic hepatitis B, HBV DNA+ve , normal ALT , HBeAg +ve
- •Chronic hepatitis B, HBV DNA +ve , normal ALT, HBeAg -ve
- •Chronic hepatitis , HBV DNA +ve, increased ALT, no HBV treatment B, HBeAg +ve
- •Chronic hepatitis B, HBV DNA +ve , increased ALT, no HBV treatment B, HBeAg -ve
- •Chronic hepatitis B, undergoing 'flare' of hepatitis
- •Group B inclusion criteria:
- •To be HIV/HBV co-infected
- •All patients:
- •To be over 18 years
排除标准
- •Those who do not fit the inclusion criteria.
研究者
Jennifer Hoy
Professor Jennifer Hoy
The Alfred
研究点 (1)
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