Stimulating the Aging Brain: Noninvasive Brain and Sensory Stimulation Strategies in Aging
试验速览
- 阶段
- 不适用
- 状态
- 招募中
- 入组人数
- 20
- 试验地点
- 1
- 主要终点
- Changes in STM capacity assessed using a verbal STM task
研究概览
简要总结
The goal of this project is to investigate whether transcranial electrical stimulation and sensory stimulation affect language outcomes in individuals with primary progressive aphasia (PPA). The main questions it aims to answer are:
Does transcranial alternating current stimulation (tACS) affect verbal short-term memory (STM) in individuals with PPA? Does a single session of multisensory stimulation affect verbal STM in individuals with PPA? Researchers will compare active tACS to sham tACS (a fake stimulation condition) to see if active tACS improves verbal STM. Researchers will compare pre-multisensory stimulation to post-stimulation performance to see if multisensory stimulation improves verbal STM.
Participants will:
Undergo EEG, MRI (anatomical and functional) May complete a cognitive exam Undergo tACS over 3 separate sessions Undergo multisensory stimulation Complete language tasks before, during and/or after stimulation
详细描述
The primary objective of the current project is to examine the effects of tACS and multisensory stimulation on verbal STM outcomes in individuals with PPA. The selection of parameters will be guided on the basis of oscillatory brain activity using language task-based or task-free EEG paradigms. Neuroimaging (MRI and functional MRI) will guide spatial targets of tACS. A secondary objective is to explore sources of individual variability in response to stimulation and whether these factors could offer insight into disease progression. This proof-of-concept, pilot project will generate essential preliminary data to help refine hypotheses for future clinical trials aimed at assessing the efficacy of these intervention strategies in predicting and treating (as in delaying) disease progression.
研究设计
- 研究类型
- Interventional
- 分配方式
- Na
- 干预模型
- Single Group
- 主要目的
- Basic Science
- 盲法
- None
盲法说明
Participants and personnel scoring the outcomes will be blinded.
入排标准
- 年龄范围
- 45 Years 至 —（Adult, Older Adult）
- 性别
- All
- 接受健康志愿者
- 否
入选标准
- •Clinical exam supports diagnosis of PPA and/or MCI with no report of difficulty functioning in basic or instrumental activities of daily living.
- •Completed clinical cognitive exam within 6 months of study baseline visit OR neuropsychological research battery within 6 months of study baseline visit.
排除标准
- •Evidence of dementia at baseline
- •Known history of neoplasm, symptomatic stroke, moderate to severe traumatic brain injury, or other significant neurologic event
- •Age <45 years.
- •Evidence of severe psychiatric illness (e.g., bipolar disorder, schizophrenia).
- •Presence of cardiac stimulators or pacemakers
- •Any other implants near the scalp or in the eye
- •Contraindications to MRI or stimulation
- •Pregnancy
- •History of ongoing or unmanaged seizures
- •History of dyslexia or other developmental learning disabilities
研究组 & 干预措施
tACS or multisensory stimulation
All participants in a within-subject design will receive high-Definition-tACS, delivered via a battery operated alternating current stimulator (Soterix) using two center-surround montages. Targets of stimulation will be localized based on the 10-10 International EEG system with center electrodes placed at a frontal and a temporoparietal site. The current is turned on and increased in a ramplike fashion over approximately 30 seconds. Participants will undergo tACS with frequencies ranging from 4-40Hz for 20-minutes with 2 milliampere (mA) peak-to-peak intensity. For sham stimulation, tACS is turned off after the first 30 seconds.
All participants will receive light and/or sound flicker stimulation using an off-the-shelf app for 20 minutes.
干预措施: tACS or multisensory stimulation (Device)
结局指标
主要结局
Changes in STM capacity assessed using a verbal STM task
时间窗: Changes monitored over pre, during and immediately after 20 minutes of tACS
Improvement in STM capacity with in-phase tACS and worsening of STM capacity with anti-phase tACS compared to sham tACS
Changes in STM capacity with multisensory stimulation using a verbal STM task
时间窗: Changes monitored pre and immediately after 20 minutes of stimulation
Improvement in STM capacity post-stimulation compared to pre-stimulation
次要结局
未报告次要终点
研究者
Priyanka Shah-Basak, PhD
Assistant Professor of Neurology
Medical College of Wisconsin