Polymorphisms in Inflammatory Cytokines Genes in Subjects With Obstructive Sleep Apnea

• Conditions: Sleep Apnea

• Registration Number: NCT00395590
• Lead Sponsor: Shaare Zedek Medical Center

Brief Summary

Obstructive sleep apnea is a common sleep disorder. It is known to be related with increased body mass, abdominal obesity, insulin resistance and hypertension. It is currently believed to be a feature of the metabolic syndrome. Other features of the metabolic syndrome-such as insulin resistace were found related to inflammation and inflammatory cytokines. Several polymorphisms in the genes that encode interleukin 6,inteleukin 10 and TNF-alpha have significant influence on the amounts of cytokine production. we thus hypothesize that polymorphisms related to increased pruduction are more common in subjects with OSA than in matched controls

Detailed Description

Patients attending a sleep apnea clinic for evluation will be recruited. Patients found positive for OSA will be compared to the patients with a negative study for OSA for the prevalence of polymorphisms in genes of inflammatory cytokines and cytokine levels

Study Timeline

• Status Verified: 2005-02
• Study Start: 2006-11
• Study First Submitted: 2006-11-02
• Study First Submitted QC: 2006-11-02
• Last Update Submitted: 2006-11-02
• Study First Posted: 2006-11-03
• Last Update Posted: 2006-11-03
• Study Completion: 2007-11

Recruitment & Eligibility

• Status: UNKNOWN
• Sex: All
• Target Recruitment: 100

Inclusion Criteria

• Patients attending the sleep apnea clinic for evaluation

Exclusion Criteria

• patients known to have inflammatory conditions

Study & Design

• Study Type: OBSERVATIONAL
• Study Design: Not specified