atural Cocoa Powder Drink and Muscle Soreness after Exercise

Not Applicable

• Conditions: Injury, Occupational Diseases, Poisoning; Musculoskeletal Diseases; Exercise-induced muscle injury, muscle soreness, adaptation

• Registration Number: PACTR201708002490201
• Lead Sponsor: /A

Brief Summary

Not available

Detailed Description

Not available

Study Timeline

• Results First Posted: 1900-01-01
• Study Start: 2017-08-02
• Last Update Posted: 29 May 2023

Recruitment & Eligibility

• Status: Pending
• Sex: All
• Target Recruitment: 96

Inclusion Criteria

Subjects will be included in the study based on the following:
(1) Subjects must maintain the usual normal activities of daily living,
(2) Subjects who are not involved in any exercise or have not performed any exercise for the past six (6) months prior to the study especially, eccentric exercises of the lower extremities such as downhill running either overground or on treadmill, running or walking down stairs, jumping or weight training.
(3) Subjects must be medically and physically fit and must be without any medical history for which the exercise protocol is contraindicated. Thus, potential participants will complete a health history questionnaire. In addition, a medical doctor will examine participants in order to include eligible ones.
(4) Subjects must be between 18 and 30 years.
(5) Subjects should have normal resting CK levels

Exclusion Criteria

Subjects will be excluded based on the following:
(1) Subjects who are already involved in structured exercise programmes or have been involved in eccentrically-biased lower limb exercises prior to the study,
(2) Subjects with anemia, musculoskeletal limitations, known inflammatory conditions, diabetes, heart disease, known kidney problems, smoking, chronic use of anti-inflammatory medications (including over-the-counter nonsteroidal anti-inflammatory drugs), pregnancy or any other conditions or medications for which exercise is contraindicated.
(3) Subjects with abnormal resting levels of the biochemical markers of muscle damage, immune function, oxidative stress and electrolyte balance.
(4) Subjects taking natural cocoa powder as beverage or on any anti-oxidant or anti-inflammatory supplements.

Study & Design

• Study Type: Interventional
• Study Design: Not specified

Primary Outcome Measures

Name	Time	Method
Plasma markers of muscle injury: creatine kinase, lactate dehydrogenase;Physical markers of muslce injury: perceived muscle soreness rating, muscle strength, muscle circumference, knee and hip range of motions;Inflammatory markers of muscle injury: Plasma IL-6, TNF-¿, and IL-10 ;oxidative stress markers: Malondialdehyde (MDA), superoxide dismutase (SOD), glutathione (GPX) and total antioxidant capacity (TAC);Electrolytes: plasma levels of Na+, K+, Ca2+, Mg2+ , Cl- and H+

Secondary Outcome Measures

Name	Time	Method
Full blood count