Cardiac involvement in patients with inflammatory bowel disease assessed by cardiovascular magnetic resonance imaging (CMR)

Not Applicable

Completed

• Conditions: Patients with inflammatory bowel disease in acute and chronic stage; Digestive System; Noninfective inflammatory bowel disease, Crohn's disease, ulcerative colitis

• Registration Number: ISRCTN30941346
• Lead Sponsor: Charité - University Medicine Berlin

Brief Summary

2024 Results article in https://pubmed.ncbi.nlm.nih.gov/39102000/ (added 06/08/2024)

Detailed Description

Not available

Study Timeline

• Study Start: 2021-03-16
• Study Completion: 2023-04-01
• Last Update Posted: 19 August 2024

Recruitment & Eligibility

• Status: Completed
• Sex: All
• Target Recruitment: 44

Inclusion Criteria

1. Aged >18 years
2. Clinically, radiologically, and histologically confirmed diagnosis of inflammatory bowel disease
3. No absolute MRI contraindications
4. Able to provide informed consent

Exclusion Criteria

1. Contraindications for MRI scan
2. Pregnancy
3. Known allergy to MRI contrast agent

Study & Design

• Study Type: Observational
• Study Design: Not specified

Primary Outcome Measures

Name	Time	Method
Diffuse or focal fibrosis measured using T1-Mapping, ECV, and late gadolinium enhancement MRI scans at baseline, 5 weeks, and 1 year

Secondary Outcome Measures

Name	Time	Method
1. Ventricular function measured using MRI cine imaging at baseline, 5 weeks, and 1 year<br>2. Edema quantification using T2-Mapping MRI scans at baseline, 5 weeks, and 1 year<br>3. Extracellular volume quantification using T1-Mapping post-contrast agent application MRI scans at baseline, 5 weeks, and 1 year