An observational study using the radioligand [11C]-UCB-J for imaging synaptic density in healthy participants, patients with a psychotic disorder and their healthy siblings - Synaptic density in psychotic disorders

niversitair Medisch Centrum Groningen0 个研究点目标入组 78 人开始时间: 待定最近更新: 2024年4月15日

适应症

试验速览

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•1. The participant understands the study and provides written informed consent
•2. Must be between the age of 26-65
•3. For patients: must have a diagnosis of schizophrenia, schizoaffective
•disorder, or schizophreniform disorder
•4. For siblings: must have 1 brother or sister with a disorder specified under
•point 3. The sibling is not necessarily related to one of the participants from
•the patient group.
•5. For controls: subjects must be free of any psychiatric or neurological
•disease and should not have any first- or second-degree relatives with one of
•the disorders specified under point 3.
•6. Dutch as native language

•1. Participation in a scientific research study during the past year involving
•radiation (or any other form of exposure to the same amount of radiation within
•the past year via, e.g., 25 or more transatlantic flights during the past year)
•2. MRI incompatible implants in the body
•3. The possibility of having metal particles in the eyes
•4. Tattoo*s containing red pigments that form a safety risk
•5. Dangerous or harmful behaviour (i.e. behaviour with a risk of severe
•physical injury, or actual physical injury inflicted, to self or others)
•occurred in the last 3 months
•6. Pregnancy
•7. Treatment with levetiracetam or brivaracetam (contraindication for
•[11C]-UCB-J)
•8. Speech disorders (e.g., stuttering)
•9. Uncorrected hearing disorder

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