An observational study using the radioligand [11C]-UCB-J for imaging synaptic density in healthy participants, patients with a psychotic disorder and their healthy siblings

Recruiting

• Conditions: cognition (thinking); Schizophrenia; 10039628

• Registration Number: NL-OMON49941
• Lead Sponsor: niversitair Medisch Centrum Groningen

Brief Summary

Not available

Detailed Description

Not available

Study Timeline

• Last Update Posted: 15 April 2024

Recruitment & Eligibility

• Status: Recruiting
• Sex: Not specified
• Target Recruitment: 78

Inclusion Criteria

1. The participant understands the study and provides written informed consent
2. Must be between the age of 26-65
3. For patients: must have a diagnosis of schizophrenia, schizoaffective
disorder, or schizophreniform disorder
4. For siblings: must have 1 brother or sister with a disorder specified under
point 3. The sibling is not necessarily related to one of the participants from
the patient group.
5. For controls: subjects must be free of any psychiatric or neurological
disease and should not have any first- or second-degree relatives with one of
the disorders specified under point 3.
6. Dutch as native language

Exclusion Criteria

1. Participation in a scientific research study during the past year involving
radiation (or any other form of exposure to the same amount of radiation within
the past year via, e.g., 25 or more transatlantic flights during the past year)
2. MRI incompatible implants in the body
3. The possibility of having metal particles in the eyes
4. Tattoo*s containing red pigments that form a safety risk
5. Dangerous or harmful behaviour (i.e. behaviour with a risk of severe
physical injury, or actual physical injury inflicted, to self or others)
occurred in the last 3 months
6. Pregnancy
7. Treatment with levetiracetam or brivaracetam (contraindication for
[11C]-UCB-J)
8. Speech disorders (e.g., stuttering)
9. Uncorrected hearing disorder

Study & Design

• Study Type: Observational non invasive
• Study Design: Not specified