Safety and Effectiveness of a New Protease Inhibitor, BMS-232632, in HIV-Positive Patients Who Have Received Previous Treatment
- Conditions
- HIV Infections
- Registration Number
- NCT00004584
- Lead Sponsor
- Bristol-Myers Squibb
- Brief Summary
The purpose of this study is to look at the safety and effectiveness of an experimental protease inhibitor (a type of anti-HIV drug) called BMS-232632. Doctors will compare an anti-HIV drug combination that includes BMS-232632 to a drug combination that includes ritonavir.
- Detailed Description
This is a three-arm study; patients are randomized to receive BMS-232632 at two different doses or RTV in combination with SQV and two nucleoside analogues over 48 weeks. Randomization is stratified for baseline phenotypic sensitivity.
Recruitment & Eligibility
- Status
- COMPLETED
- Sex
- All
- Target Recruitment
- Not specified
Not provided
Not provided
Study & Design
- Study Type
- INTERVENTIONAL
- Study Design
- Not specified
- Primary Outcome Measures
Name Time Method
- Secondary Outcome Measures
Name Time Method
Trial Locations
- Locations (38)
HIV Clinical Research
🇺🇸Fort Lauderdale, Florida, United States
Infectious Disease Specialists of Atlanta
🇺🇸Decatur, Georgia, United States
Albany Med College
🇺🇸Albany, New York, United States
Univ Hosps of Cleveland
🇺🇸Cleveland, Ohio, United States
Univ of Texas Southwestern Med Ctr of Dallas
🇺🇸Dallas, Texas, United States
Ottawa General Hospital
🇨🇦Ottawa, Ontario, Canada
Toronto Hosp
🇨🇦Toronto, Ontario, Canada
Houston Clinical Research Network / Div of Montrose Clinic
🇺🇸Houston, Texas, United States
Yale Univ School of Medicine / AIDS Program
🇺🇸New Haven, Connecticut, United States
Julio Arroyo
🇺🇸West Columbia, South Carolina, United States
Montreal Chest Institute
🇨🇦Montreal, Quebec, Canada
Vanderbilt Univ Med Ctr
🇺🇸Nashville, Tennessee, United States
Reparto Malattie Infettive
🇮🇹Antella, Italy
Ospedale Luigi Cacco Moroni
🇮🇹Milano, Italy
Sorra Research Ctr / Med Forum
🇺🇸Birmingham, Alabama, United States
The Research and Education Group
🇺🇸Portland, Oregon, United States
Robert Scott MD
🇺🇸Oakland, California, United States
Community Research Initiative of South Florida
🇺🇸Coral Gables, Florida, United States
Univ of California - Davis Med Ctr / CARES
🇺🇸Sacramento, California, United States
Avalar Medical Group
🇺🇸Tarzana, California, United States
Infectious Disease Research Institute
🇺🇸Tampa, Florida, United States
Louisiana State Univ Med Ctr / HIV Outpatient Clinic
🇺🇸New Orleans, Louisiana, United States
St Vincents Hosp / Clinical Research Program
🇺🇸New York, New York, United States
Texas Tech Health Sciences Ctr
🇺🇸El Paso, Texas, United States
Hopital De L'Hotel Dieu
🇫🇷Nantes, France
Hopital Pellegrin Tripode
🇫🇷Bordeaux, France
Hopital Paul Brousse
🇫🇷Villejuif, France
Hopital De L'Archet 1
🇫🇷Nice, France
Srev Du Pr Gentilini
🇫🇷Paris Cedex 13, France
Brennerstr 71
🇩🇪Hamburg, Germany
Hopital De Haut Leveque
🇫🇷Pessac, France
Hospital Gustave Dron
🇫🇷Tourcoing, France
Georg-Str 46
🇩🇪Hanover, Germany
Clinical Malattie Infettive
🇮🇹Milano, Italy
Praxisgemeinschaft
🇩🇪Munich, Germany
Clinical Malattie Infettive / Univ Modena
🇮🇹Modena, Italy
Ospedale degli Infermi
🇮🇹Rimini, Italy
AIDS Healthcare Foundation
🇺🇸Los Angeles, California, United States