A Study of Erlotinib (Tarceva) After Surgery With or Without Adjuvant Chemotherapy in Non-Small Cell Lung Carcinoma (NSCLC) Patients Who Have Epidermal Growth Factor Receptor (EGFR) Positive Tumors
- Registration Number
- NCT00373425
- Lead Sponsor
- OSI Pharmaceuticals
- Brief Summary
This is a study to evaluate the effectiveness of erlotinib compared with a placebo sugar pill following complete surgical removal of the tumor with or without chemotherapy after surgery in Stage IB-IIIA NSCLC patients.
- Detailed Description
After the initiation of the study, the sponsor became aware of an error in the drug dispensing module of the interactive voice response such that most patients who were randomized prior to 07 November 2007 were dispensed the incorrect study drug at least once. Since the integrity of the data from these patients was seriously compromised, these patients were considered unevaluable for the protocol-specified analyses. These participants are referred to as the breached protocol cohort (BPC) and those still on study treatment at the time of the breach were offered the option of receiving open-label erlotinib for up to 2 years (including posttreatment and long-term follow-up assessments), not receiving open-label erlotinib but remaining in the study for posttreatment and long-term follow-up assessment, or withdrawing consent from treatment and further assessments. Participants who had discontinued study treatment prior to the breach were not offered open-label erlotinib and remained in long-term follow-up. Data from the BPC participants were analyzed separately and were not included in the assessments of primary or secondary endpoints in the randomized cohort and were not considered part of the primary analyses.The sample size for the randomized cohort was not changed due to the BPC and the data from RC and BPC were analyzed separately.
Recruitment & Eligibility
- Status
- COMPLETED
- Sex
- All
- Target Recruitment
- 1252
-
Primary tissue from patient's surgery must be epidermal growth factor receptor (EGFR)-positive by certain tests
-
Patients may have up to 4 cycles of chemotherapy after surgery
-
Complete removal of the tumor by surgery
-
Able to start drug under the following timelines:
- 6 months from the day of surgery for patients who get chemotherapy
- 3 months from the day of surgery for those who do not get chemotherapy
-
Confirmed diagnosis of Stage IB-IIIA NSCLC
-
Patients must be accessible for follow-up visits
- History of prior radiotherapy for NSCLC either before or after surgery
- History of heart disease or uncontrolled heart arrhythmias within the previous year
- History of poorly controlled gastrointestinal (GI) disorders that could affect the absorption of study drug
- History of other cancer except certain skin or cervical cancers, patients who have had other cancer are eligible if they have remained disease free for at least 5 years
- Patients who have received chemotherapy for NSCLC before surgery
- Tumors with mixed histology of NSCLC and Small Cell Lung Cancer (SCLC). Patients with carcinoid tumors are not eligible.
Study & Design
- Study Type
- INTERVENTIONAL
- Study Design
- PARALLEL
- Arm && Interventions
Group Intervention Description Placebo Placebo Participants received matching placebo tablets orally for 2 years or until relapse, death, participant request or investigator decision to discontinue study drug, or intolerable toxicity. Erlotinib Erlotinib Participants received 150 mg/day erlotinib orally for 2 years or until relapse, death, participant request or investigator decision to discontinue study drug, or intolerable toxicity.
- Primary Outcome Measures
Name Time Method Disease Free Survival (DFS) Every 3 months during active phase and every 6 months during long term follow-up up to 5 years and yearly thereafter until the data cutoff date of 11 June 2014 (maximum time on follow-up was 78 months). DFS is the time from the date of randomization until the first day that non-small cell lung cancer (NSCLC) relapse is documented by radiological exam and/or biopsy, or until death in the absence of relapse. After randomization, NSCLC relapse was based on radiological evidence or biopsy, as determined by the investigator. Participants without a DFS event were censored on the last adequate radiological assessment date.
- Secondary Outcome Measures
Name Time Method Overall Survival (OS) Every 3 months during active phase and every 6 months during long term follow-up up to 5 years and yearly thereafter until the data cut-off date of 11 June 2014 (maximum time on follow-up was 78 months). Overall survival was defined as the time from the date of randomization until the documented date of death. Participants who were still alive were censored on the last day they were known to be alive.
Overall Survival in Participants With EGFR Mutation - Positive Tumors Every 3 months during active phase and every 6 months during long term follow-up up to 5 years and yearly thereafter until the data cut-off date of 11 June 2014 (maximum time on follow-up was 78 months) Overall survival is defined as the time from the date of randomization until the documented date of death. Participants who were still alive were censored on the last day they were known to be alive.
Activating EGFR mutation-positive is defined as exon 19 deletion or exon 21 L858R (or both) detected.Disease-free Survival in Participants With EGFR Mutation - Positive Tumors Every 3 months during active phase and every 6 months during long term follow-up up to 5 years and yearly thereafter until the data cut-off date of 11 June 2014 (maximum time on follow-up was 78 months). Disease-free survival (DFS) is the time from the date of randomization until the first day NSCLC relapse is documented by radiological exam and/or biopsy, or until death in the absence of relapse. After randomization, NSCLC relapse was based on radiological evidence or biopsy, as determined by the investigator. Participants without a DFS event were censored on the last adequate radiological assessment date. Activating EGFR mutation-positive is defined as exon 19 deletion or exon 21 L858R (or both) detected.
Number of Participants With Adverse Events (AEs) From the date of first dose of study drug until 30 days after the last dose. The median time on treatment was 11.9 months for erlotinib and 21.9 months for placebo. Data are based off the 11 June 2014 data cut-off date. An AE was defined as any untoward medical occurrence in a study participant and did not necessarily have a causal relationship with study treatment.
An AE was considered serious if it resulted in death, a life-threatening situation, inpatient hospitalization or prolongation of existing hospitalization, persistent or significant disability/incapacity, congenital anomaly/birth defect in the offspring of a participant, other important medical events, or is on the Astellas Always Serious List.
A drug-related AE was any AE with at least a possible relationship to study treatment as assessed by the investigator. Severity was graded by the investigator according to the National Cancer Institute Common Terminology Criteria for Adverse Events, v3.0, where Grade 1=Mild AE; Grade=2 Moderate AE; Grade 3=Severe AE; Grade 4=Life-threatening or disabling; Grade 5=Death related to AE. AEs leading to death include deaths that occurred more than 30 days after the last dose of study drug.
Trial Locations
- Locations (261)
Kootenai Cancer Center
🇺🇸Post Falls, Idaho, United States
University of Arkansas for Medical Science
🇺🇸Little Rock, Arkansas, United States
Tower Cancer Research Foundation
🇺🇸Beverly Hills, California, United States
Arizona Cancer Center
🇺🇸Tucson, Arizona, United States
Loma Linda University Medical Center
🇺🇸Loma Linda, California, United States
USC/ Norris Comprehensive Cancer Center
🇺🇸Los Angeles, California, United States
Cedars-Sinai Medical Center
🇺🇸Los Angeles, California, United States
Comprehensive Cancer Center at Desert Regional Medical Center
🇺🇸Palm Springs, California, United States
Bay Area Cancer Research Group, LLC
🇺🇸Pleasant Hill, California, United States
City of Hope Medical Group (COHMG)
🇺🇸South Pasadena, California, United States
Rocky Mountain Cancer Centers-Boulder
🇺🇸Boulder, Colorado, United States
Rocky Mountain Cancer Center
🇺🇸Colorado Springs, Colorado, United States
Rocky Mountain Cancer Center-Sky Ridge
🇺🇸Lone Tree, Colorado, United States
Yale University
🇺🇸New Haven, Connecticut, United States
Smilow Cancer Hospital Care Center
🇺🇸Torrington, Connecticut, United States
Florida Cancer Institute-New Hope
🇺🇸Hudson, Florida, United States
Cancer Specialists of North Florida
🇺🇸Jacksonville, Florida, United States
Watson Clinic LLP
🇺🇸Lakeland, Florida, United States
Advanced Medical Specialties
🇺🇸Miami, Florida, United States
Florida Cancer Institute- New Hope
🇺🇸New Port Richey, Florida, United States
Hematology Oncology Associates of the Treasure Coast
🇺🇸Port St. Lucie, Florida, United States
Peachtree Hematology-Oncology Consultants, P.C.
🇺🇸Atlanta, Georgia, United States
Central Georgia Cancer Care, PC
🇺🇸Macon, Georgia, United States
Northwest Georgia Oncology Centers, PC
🇺🇸Marietta, Georgia, United States
Mountain States Tumor Institute
🇺🇸Twin Falls, Idaho, United States
Rush University Medical Center
🇺🇸Chicago, Illinois, United States
University of Chicago, Section of Hematology/Oncology
🇺🇸Chicago, Illinois, United States
Joliet Oncology Hematology Assoc., LTD
🇺🇸Joliet, Illinois, United States
Loyola University Medical Center
🇺🇸Maywood, Illinois, United States
Leonard J. Chabert Medical Center
🇺🇸Houma, Louisiana, United States
Norton Healthcare, Inc.
🇺🇸Louisville, Kentucky, United States
Cancer Care of Maine
🇺🇸Brewer, Maine, United States
Greater Baltimore Medical Center
🇺🇸Baltimore, Maryland, United States
Caritas St. Elizabeth's Medical Center
🇺🇸Boston, Massachusetts, United States
St. Joseph Medical Center's Cancer Institute
🇺🇸Towson, Maryland, United States
Minnesota Oncology Hematology, P.A.
🇺🇸Woodbury, Minnesota, United States
Minnesota Oncology Hematology
🇺🇸St. Paul, Minnesota, United States
Missouri Cancer Associates
🇺🇸Columbia, Missouri, United States
Heartland Regional Medical Center d/b/a Heartland Clinic
🇺🇸St. Joseph, Missouri, United States
St. Francis Cancer Treatment Center
🇺🇸Grand Island, Nebraska, United States
Comprehensive Cancer Centers of Nevada
🇺🇸Las Vegas, Nevada, United States
NH Oncology-Hematology PA (Co)
🇺🇸Concord, New Hampshire, United States
Dartmouth-Hitchcock Medical Center
🇺🇸Lebanon, New Hampshire, United States
University of New Mexico Health Science Center
🇺🇸Albuquerque, New Mexico, United States
Christus St. Vincent Regional Cancer Center
🇺🇸Santa Fe, New Mexico, United States
Interlakes Oncology Hematology, PC
🇺🇸Rochester, New York, United States
Advanced Oncology Associates
🇺🇸New Rochelle, New York, United States
The New York Presbyterian-Weill Medical College of Cornell University
🇺🇸New York, New York, United States
Stony Brook University Medical Center
🇺🇸Stony Brook, New York, United States
Carolina Oncology Specialists PA
🇺🇸Hickory, North Carolina, United States
Raleigh Hematology Oncology Associates d/b/a Cancer Center of North Carolina
🇺🇸Cary, North Carolina, United States
Aultman Hospital/ North Canton Medical Foundation
🇺🇸Canton, Ohio, United States
Raleigh Hematology Oncology Associates
🇺🇸Raleigh, North Carolina, United States
University Hopsitals of Cleveland
🇺🇸Cleveland, Ohio, United States
Hematology Oncology Consultants Inc.
🇺🇸Columbus, Ohio, United States
Cancer Care Associates - Medical Oncology
🇺🇸Bethlehem, Pennsylvania, United States
The Hospital of the University of Pennsylvania
🇺🇸Philadelphia, Pennsylvania, United States
Cookeville Regional Medical Center
🇺🇸Cookeville, Tennessee, United States
South Carolina Oncology Assoc., PA
🇺🇸Columbia, South Carolina, United States
Cancer Centers of the Carolinas
🇺🇸Spartanburg, South Carolina, United States
Bostin Baskin Cancer Foundation
🇺🇸Memphis, Tennessee, United States
Tennessee Cancer Specialists
🇺🇸Knoxville, Tennessee, United States
Family Cancer Center Foundation, Inc.
🇺🇸Memphis, Tennessee, United States
West Clinic
🇺🇸Memphis, Tennessee, United States
Texas Oncology, P.A. - Amarillo
🇺🇸Amarillo, Texas, United States
Texas Oncology Beaumont
🇺🇸Beaumont, Texas, United States
Texas Oncology Texas Cancer Center at Medical City
🇺🇸Dallas, Texas, United States
Baylor Charles A Sammons Cancer Center
🇺🇸Dallas, Texas, United States
Texas Oncology - Flower Mound
🇺🇸Flower Mound, Texas, United States
Cancer Care Centers of South Texas - HOAST
🇺🇸New Braunfels, Texas, United States
Texas Oncology Southwest Forth Worth
🇺🇸Fort Worth, Texas, United States
Texas Oncology, Fort Worth
🇺🇸Ft. Worth, Texas, United States
Texas Oncology, Garland
🇺🇸Garland, Texas, United States
Texas Oncology - Paris
🇺🇸Paris, Texas, United States
Texas Oncology - Plano East
🇺🇸Plano, Texas, United States
Texas Oncology -Tyler
🇺🇸Tyler, Texas, United States
Texas Oncology Cancer Care and Research Center
🇺🇸Waco, Texas, United States
Onc and Hem Associates of SW VA, Inc. d/b/a Blue Ridge Cancer Care
🇺🇸Wytheville, Virginia, United States
Virginia Oncology Associates
🇺🇸Norfolk, Virginia, United States
Onc and Hem Assoc of SW VA, Inc d/b/a Blue Ridge Cancer Care
🇺🇸Salem, Virginia, United States
Univ. of Washington/ Seattle Cancer Care Alliance
🇺🇸Seattle, Washington, United States
Cancer Care Northwest-Valley
🇺🇸Spokane Valley, Washington, United States
Cancer Care Northwest
🇺🇸Spokane, Washington, United States
Cancer Care Northwest-North
🇺🇸Spokane, Washington, United States
Northwest Cancer Specialists, P.C.
🇺🇸Vancouver, Washington, United States
Hospital Italiano de Buenos Aires
🇦🇷Buenos Aires, Argentina
Northwest Cancer Specialist, P.C.
🇺🇸Vancouver, Washington, United States
Hospital de Rehabilitación Respiratoria María Ferrer
🇦🇷Buenos Aires, Argentina
COIR
🇦🇷Mendoza, Argentina
Hospital Espanol de Rosario
🇦🇷Rosario, Santa Fe, Argentina
Liverpool Hospital
🇦🇺Liverpool, New South Wales, Australia
ISIS Centro Especializado De Luce S.A.
🇦🇷Santa Fé, Argentina
Royal North Shore Hospital
🇦🇺St Leonards, New South Wales, Australia
St Vincent's Hospital Melbourne
🇦🇺Fitzroy, Victoria, Australia
Respiratory Clinical Trials Pty., Ltd
🇦🇺Adelaide, Australia
Monash Medical Centre
🇦🇺East Bentleigh, Victoria, Australia
Austin Hospital
🇦🇺Heidelberg, Victoria, Australia
Ashford Cancer Centre
🇦🇺Ashford, Australia
Universitaetsklinikum Innsbruck
🇦🇹Innsbruck, Austria
Allgemeines Krankenhaus der Stadt Linz
🇦🇹Linz, Austria
Landeskrankenhaus SalzburgUniversitaetsklinikum der PMUUniversitaetsklinik für Pneumologie
🇦🇹Salzburg, Austria
AKH Wien
🇦🇹Wien, Austria
SMZ Baumgartner Hoehe - Otto Wagner Spital
🇦🇹Wien, Austria
Krankenhaus Hietzing
🇦🇹Wien, Austria
SMZ Baumgartner Höhe - Otto- Wagner-Spital
🇦🇹Wien, Austria
Hôpital Erasme
🇧🇪Brussels, Belgium
Cliniques Universitaires Saint-Luc
🇧🇪Brussels, Belgium
Centre Hospitalier Jolimont-Lobbes
🇧🇪La Louvière, Belgium
Cross Cancer Institute
🇨🇦Edmonton, Alberta, Canada
Trillium Health Partners - Credit Valley Hospital
🇨🇦Mississauga, Ontario, Canada
Cancer Center of Southeastern Ontario at Kingston General Hospital
🇨🇦Kingston, Ontario, Canada
Stronach Regional cancer Centre at Southlake
🇨🇦Newmarket, Ontario, Canada
Sault Area Hospital
🇨🇦Sault Ste Marie, Ontario, Canada
RS MacLaughlin Durham Regional Cancer Centre
🇨🇦Oshawa, Ontario, Canada
Thunder Bay Regional Health Science Centre
🇨🇦Thunder Bay, Ontario, Canada
Royal Victoria Hospital
🇨🇦Montreal, Quebec, Canada
Toronto General Hospital
🇨🇦Toronto, Ontario, Canada
McGill Dept. of Oncology
🇨🇦Montreal, Quebec, Canada
St. Joseph's Health Centre
🇨🇦Toronto, Canada
Nemocnice Ceske Budejovice, a.s.
🇨🇿Ceske Budejovice, Czech Republic
Montreal General Hospital
🇨🇦Montreal, Quebec, Canada
Fakultni nemocnice OstravaKlinika tuberkulozy a respiracnich nemoci
🇨🇿Ostrava-Poruba, Czech Republic
FN Bulovka Klinika plincni a hrrudni chirurgie
🇨🇿Praha, Czech Republic
CHU Larrey Service de Pneumologie, Clinique des voies respiratoires
🇫🇷Toulouse, Cedex 9, France
Centre d'Oncologie et de Radiothérapie du Pays Basque
🇫🇷Bayonne, France
C.H.U. Morvan, Institut de Cancerologie et d'Hématologie
🇫🇷Brest cedex, France
CHU de Caen - Service de pneumologie
🇫🇷Caen Cedex, France
CHU Clermont Ferrand - Hôpital Gabriel Montpied - Service de pneumologie
🇫🇷Clermont-Ferrand cedex 1, France
Hopital De La Croix-Rousse Service de Pneumologie
🇫🇷Lyon cedex 04, France
Institut Paoli-Calmettes
🇫🇷Marseille cedex 9, France
Fondation Hôpital Saint Joseph
🇫🇷PARIS cedex 14, France
Hôpital de Tenon
🇫🇷Paris, France
CHU - Hopital Pontchaillou - Service de pneumologie
🇫🇷Rennes cedex 9, France
Centre Catalan d'Oncologie
🇫🇷Perpignan, France
Hôpital de Brabois
🇫🇷Vandoeuvre-lès-Nancy Cedex, France
Augusta-Krankenanstalt Bochum
🇩🇪Bochum, Germany
Institut de Cancérologie de la Loire
🇫🇷Saint Priest en Jarez, France
Zentralklinik Bad Berka
🇩🇪Bad Berka, Germany
HELIOS Klinikum Emil von Behring GmbH
🇩🇪Berlin, Germany
Fachkrankenhaus Coswig
🇩🇪Coswig, Germany
Lungenclinic Großhansdorf
🇩🇪Großhansdorf, Germany
Universitaetsklinikum Essen
🇩🇪Essen, Germany
Krankenhaus Nordwest
🇩🇪Frankfurt/Main, Germany
Universitätsklinikum Göttingen
🇩🇪Göttingen, Germany
Universitätsklinikum Freiburg
🇩🇪Freiburg, Germany
Asklepios Klinik Harburg
🇩🇪Hamburg, Germany
Städtisches Krankenhaus Martha-Maria, Halle-Dölau
🇩🇪Halle (Saale), Germany
Thoraxklinik Heidelberg
🇩🇪Heidelberg, Germany
Lungenklink Hemer des Deutschen Gemeinschafts-Diakonieverbandes GmbH
🇩🇪Hemer, Germany
St. Vincentius-Kliniken Karlsruhe
🇩🇪Karlsruhe, Germany
Universitaetsklinikum Schleswig-Holstein
🇩🇪Lübeck, Germany
Asklepios Klinikum Gauting
🇩🇪Muenchen-Gauting, Germany
Universitätsklinikum Mainz
🇩🇪Mainz, Germany
Pius Hospital Oldenburg
🇩🇪Oldenburg, Germany
Schwarzwald-Baar Klinikum
🇩🇪Villingen-Schwenningen, Germany
IASO GENERAL Hospital of Athens
🇬🇷Athens, Greece
"Papageorgiou" General Hospital of Thessaloniki
🇬🇷Thessaloniki, Greece
"G. Papanikolaou" General Hospital of Thessaloniki
🇬🇷Thessaloniki, Greece
Országos Korányi TBC és Pulmonológiai Intézet
🇭🇺Budapest, Hungary
Semmelweis Egyetem Altalanos Orvostudomanyi Kar Pulmonologiai Klinika
🇭🇺Budapest, Hungary
Csongrad Megyei Onkormanyzat, Mellkasi Betegsegek Szakkorhaza
🇭🇺Deszk, Hungary
Fejer Megyei Szent Gyorgy Korhaz
🇭🇺Szekesfehervar, Hungary
Vas Megyei Markusovszky Lajos Altalanos Rehabilitacios es Gyogyfurdo Korhaz, Egyetemi Oktatoko Zarkoruen Mukodo Nonprofit Reszveny Tarsasag
🇭🇺Szombathely, Hungary
Azienda Ospedaliero Universitaria Ospedali Riuniti Umberto I
🇮🇹Ancona, Italy
Ospedale Bellaria
🇮🇹Bologna, Italy
Ospedale Garibaldi Nesima
🇮🇹Catania, Italy
Azienda Ospedaliero- Universitaria di Parma
🇮🇹Parma, Italy
Ospedale S. Maria della Misericordia
🇮🇹Perugia, Italy
Saint Vincent's Hospital
🇰🇷Gyeonggi-Do, Korea, Republic of
Gachon Medical School Ghil Medical Center
🇰🇷Incheon, Korea, Republic of
Severance Hospital, Yonsei Univ. College of Medicine
🇰🇷Seoul, Korea, Republic of
Seoul National University Hospital
🇰🇷Seoul, Korea, Republic of
Asan Medical Center
🇰🇷Seoul, Korea, Republic of
Mazowieckie Centrum Leczenia Chorob Pluc i Gruzlicy
🇵🇱Otwock, Poland
Samodzielny Publiczny Szpital Kliniczny Nr 4
🇵🇱Lublin, Poland
Specjalistyczny Szpital im. prof.Alfreda Sokolowskiego
🇵🇱Szczecin, Poland
Centrum Onkologii - Instytut im. Marii Skllodowskiej - Curie
🇵🇱Warsaw, Poland
Wielkoposkie Centrum Pulmonologii i Torakochirurgii, Oddzial Onkologii Klinicznej z Pododdzialem Dziennej Chemioterapii
🇵🇱Poznan, Poland
Spitalui Clinic Judetean de Urgenta, Sectia de Oncologie
🇷🇴Oradea, Bihor, Romania
Institutul Oncologic Prof. Dr. Ion Chiricuta
🇷🇴Cluj-Napoca, Romania
Oncoloab SRL
🇷🇴Craiova, Dolj, Romania
Institutul Oncologic Al. Trestioreanu Sectia Oncologie Medicala II
🇷🇴Bucuresti, Romania
Centrul de Oncologie Medicala
🇷🇴Iasi, Romania
Institutul Oncologic Al. Trestioreanu
🇷🇴Bucuresti, Romania
Spitalul Clinic Judetean Sibiu
🇷🇴Sibiu, Romania
State Healthcare Institution "Arkhangelsk Regional Clinical Oncology Dispensary"
🇷🇺Arkhangelsk, Russian Federation
State Healthcare Institution "Regional Clinical Oncology Dispensary"
🇷🇺Kemerovo, Russian Federation
State Healthcare Institution "Region Clinical Hospital # 1 n.a. professor S.V. Ochapovsky"
🇷🇺Krasnodar, Russian Federation
Indiana University Health
🇺🇸Indianapolis, Indiana, United States
State Institution "Central Military Clinical Hospital n.a. academician N.N. Burdenko under the Ministry of Defense of Russia"
🇷🇺Moscow, Russian Federation
Institution of the RAMS "Russian Oncology Scientific Centre n.a. N.N. Blokhin under the Russian Academy of Medical Sciences"
🇷🇺Moscow, Russian Federation
Saint-Petersburg State Healthcare Institution "City Clinical Oncology Dispensary"
🇷🇺Saint-Petersburg, Russian Federation
State Healthcare Institution of Yaroslavl Region "Regional Clinical Oncology Hospital"
🇷🇺Yaroslavl, Russian Federation
Fundació Althaia
🇪🇸Manresa, Barcelona, Spain
ICO (Institut Catalá d´Oncología)
🇪🇸L' Hospitalet de Llobregat, Barcelona, Spain
Corporació Sanitaria Parc Taulí
🇪🇸Sabadell, Barcelona, Spain
Hospital Puerta de Hierro Majadahonda
🇪🇸Majadahonda, Madrid, Spain
Hospital Oncologico MD Anderson
🇪🇸Madrid, Spain
Hospital Universitario 12 de Octubre
🇪🇸Madrid, Spain
Hospital Universitario La Paz
🇪🇸Madrid, Spain
Hospital Carlos Haya
🇪🇸Málaga, Spain
Clinica Universitaria de Navarra
🇪🇸Pamplona, Spain
Hospital Clínico Virgen de la Victoria
🇪🇸Málaga, Spain
Hospital Universitario Marques de Valdecilla
🇪🇸Santander, Spain
Hospital Universitario de Valme
🇪🇸Sevilla, Spain
Changhua Christian Hospital
🇨🇳Changhua, Taiwan
Hospital General Universitario de Valencia
🇪🇸Valencia, Spain
Hospital Virgen de la Salud de Toledo
🇪🇸Toledo, Spain
Chang Gung Medical Foundation
🇨🇳Kaohsiung, Taiwan
Chung Shan Medical University Hospital
🇨🇳Taichung, Taiwan
China Medical University Hospital
🇨🇳Taichung, Taiwan
Taichung Veterans General Hospital
🇨🇳Taichung, Taiwan
Taipei Veterans General Hospital
🇨🇳Taipei, Taiwan
Chang Gung Memorial Hospital
🇨🇳Taoyuan, Taiwan
Birmingham Heartlands Hospital
🇬🇧Birmingham, United Kingdom
Bristol Haematology and Oncology Centre
🇬🇧Bristol, United Kingdom
Ninewells Hospital
🇬🇧Dundee, United Kingdom
Beatson West of Scotland Cancer Centre
🇬🇧Glasgow, United Kingdom
The Royal Surrey County Hospital NHS Trust
🇬🇧Guildford, United Kingdom
Leicester Royal Infirmary
🇬🇧Lecester, United Kingdom
St James' Institute of Oncology, Bexley Wing, St James' University Hospital
🇬🇧Leeds, United Kingdom
Royal Marsden Hospital
🇬🇧Sutton, United Kingdom
Cancer Care Centers of South Texas-HOAST
🇺🇸San Antonio, Texas, United States
Onc and Hem Associates of SW VA, Inc.
🇺🇸Christiansburg, Virginia, United States
Rocky Mountain Cancer Center-Parker
🇺🇸Parker, Colorado, United States
Penrose St. Francis Health Services
🇺🇸Colorado Springs, Colorado, United States
Rocky Mountain Cancer Centers-Longmont
🇺🇸Longmont, Colorado, United States
Rocky Mountain Cancer Centers
🇺🇸Thornton, Colorado, United States
Rocky Mountain Cancer Centers-Littleton
🇺🇸Littleton, Colorado, United States
Northwest Cancer Specialists, PC
🇺🇸Tualatin, Oregon, United States
Le Grand Hôpital de Charleroi
🇧🇪Charleroi, Belgium
Istituto Nazionale per la Ricerca e la Cura del Cancro
🇮🇹Genova, Italy
Azienda Ospedaliera San Camillo Forlanini
🇮🇹Roma, Italy
University of Alabama at Birmingham
🇺🇸Birmingham, Alabama, United States
University of California, San Francisco Comprehensive Cancer Center
🇺🇸San Francisco, California, United States
Rocky Mountain Cancer Center- Aurora
🇺🇸Aurora, Colorado, United States
University of Colorado Hospital
🇺🇸Aurora, Colorado, United States
Rocky Mountain Cancer Center-Midtown
🇺🇸Denver, Colorado, United States
Rocky Mountain Cancer Centers- Rose
🇺🇸Denver, Colorado, United States
Nebraska Methodist Hospital
🇺🇸Omaha, Nebraska, United States
Sarah Cannon Cancer Center
🇺🇸Nashville, Tennessee, United States
Sarah Cannon Research Institute
🇺🇸Nashville, Tennessee, United States
Earle A Chiles Research Institute
🇺🇸Portland, Oregon, United States
Allegheny General Hospital
🇺🇸Pittsburg, Pennsylvania, United States
Campbelltown Hospital
🇦🇺Campbelltown, New South Wales, Australia
Hoag Memorial Hospital Presbyterian
🇺🇸Newport Beach, California, United States
St. Joseph Mercy Hospital
🇺🇸Ann Arbor, Michigan, United States
Hematology Oncology, P.C.
🇺🇸Stamford, Connecticut, United States
Hackensack University Medical Center
🇺🇸Hackensack, New Jersey, United States
Cancer Centers of the Carolinas, Seneca
🇺🇸Seneca, South Carolina, United States
Pecsi Tudomany Egyete m Klinikai Kozpont, I.sz Belgyogyaszati Klinika Pulmonologiai Munkacsoport
🇭🇺Pécs, Hungary
Dolnoslaskie Centrum Chorob Pluc we Wroclawiu, Katedra i Klinika Pulmonologii i Nowotworow Pluc Akademii Medycznej
🇵🇱Wroclaw, Poland
State Educational Institution of Higher Professional Education "Saint-Petersburg State Medical University n.a. ac. I.P. Pavlov of the Ministry of Healthcare and Social Development of the Russian Federation"
🇷🇺Saint-Petersburg, Russian Federation
Federal State Institution "Petrov Scientific Research Institute of Oncology of Rosmedtechnology"
🇷🇺Saint-Petersburg, Russian Federation
Regional State Budget Healthcare Instiution"Tomsk Regional Oncology Dispensary"
🇷🇺Tomsk, Russian Federation
Florida Cancer Specialists
🇺🇸Orlando, Florida, United States
City of Hope Nat'l Medical Center
🇺🇸Duarte, California, United States
NH Oncology-Hematology PA
🇺🇸Hooksett, New Hampshire, United States
Guy's Hospital
🇬🇧London, United Kingdom
Montefiore Medical Center
🇺🇸Bronx, New York, United States
University of Kansas Medical Center
🇺🇸Westwood, Kansas, United States