Ziprasidone and Sertraline in PTSD
- Conditions
- Post-traumatic Stress Disorder
- Registration Number
- NCT00248261
- Lead Sponsor
- Universitätsklinikum Hamburg-Eppendorf
- Brief Summary
Serotonin re-uptake inhibitors, such as sertraline, are the medication of choice in post-traumatic stress disorder. However, it takes several weeks before they ameliorate symptoms. Therefore, we will add ziprasidone (vs. placebo) medication during the first four weeks of sertraline in order to find out if this strategy accelerates symptomatic relief.
- Detailed Description
A current problem in the pharmacotherapy of PTSD is that the medication of choice, serotonin re-uptake inhibitors, take several weeks before they show considerable effects on PTSD symptoms. Addition of typical neuroleptics, such as ziprasidone, offers a potential strategy to bring about a faster symptomatic relief, because they display anxiolytic properties without the risk of dependence. Therefore, in addition to standard sertraline therapy (at least 8 weeks), we will give ziprasidone vs. placebo over the first four weeks in a double-blind randomized design.
Recruitment & Eligibility
- Status
- TERMINATED
- Sex
- All
- Target Recruitment
- 7
Clinical diagnosis of Post-Traumatic Stress Disorder
Lifetime psychotic disorders, current substance dependency, gravidity, lactation, tartrazine hypersensitivity, contraindication against sertraline or ziprasidone
Study & Design
- Study Type
- OBSERVATIONAL
- Study Design
- Not specified
- Primary Outcome Measures
Name Time Method Post-Traumatic Diagnostic Scale (PDS) 56 days
- Secondary Outcome Measures
Name Time Method Beck Depression Inventory (BDI) 56 days
Trial Locations
- Locations (1)
UKE, Dept. of Psychiatry and Psychotherapy
🇩🇪Hamburg, Germany