To study the effectiveness of normal saline vs ringers lactate as resuscitative fluids in pediatric patients with shock .
试验速览
- 阶段
- 3 期
- 状态
- 尚未招募
- 发起方
- 入组人数
- 26
- 试验地点
- 1
- 主要终点
- Primary objective : to compare level of acidosis (ph and bicarbonate ) in children with shock receiving ringer lactate or normal saline as resuscitative fluid.
研究概览
简要总结
To study effectiveness of normal saline vs ringers lactate as resuscitative fluids in pediatric patients with shock presenting to tertiary care hospital Aurangabad .
Primary objective : To compare level of acidosis (ph. and bicarbonate ) in children with shock receiving ringer lactate or normal saline as resuscitative fluid.
Secondary objective : To compare :
-
Metabolic response : Electrolytes : ( sodium , chloride , potassium ) , lactate , renal function tests
-
Hemodynamic Response : Heart rate , blood pressure
-
Inflammatory markers : CRP
研究设计
- 研究类型
- Interventional
- 分配方式
- Randomized
- 盲法
- Participant Blinded
入排标准
- 年龄范围
- 1.00 Month(s) 至 18.00 Year(s)（—）
- 性别
- All
入选标准
- •children included in the study which are more than 1 month upto 18 years of life presenting with shock requiring fluids resuscitation in casualty , ward or picu .
排除标准
- •patients who have been diagnosed with diabetic ketoacidosis 2) patients who have been diagnosed with chronic kidney diseases 3) for patients with inborn errors of metabolism 4) children undergoing chemotherapy.
结局指标
主要结局
Primary objective : to compare level of acidosis (ph and bicarbonate ) in children with shock receiving ringer lactate or normal saline as resuscitative fluid.
时间窗: assessment will be at 0 hours ( i.e before administration of iv fluid as normal saline or ringers lactate ), 6 hours , 12 hours and 24 hours after administration of iv fluid as bolus .
次要结局
- Secondary objective : to compare: 1) metabolic response : electrolytes (sodium, chloride ,potassium) lactate, renal function tests(2) hemodynamic response :heart rate , blood pressure)
研究者
Dr. Fatima Huda
MGM MEDICAL COLLEGE AND HOSPITAL