Effect of Preoperative Chemoradiotherapy on Exercise Capacity as Measured by Cardiopulmonary Exercise Testing

Imperial College London1 site in 1 country40 target enrollmentJanuary 2009

ConditionsColorectal Cancer

Overview

Phase: Not Applicable
Intervention: Not specified
Conditions: Colorectal Cancer
Sponsor: Imperial College London
Enrollment: 40
Locations: 1
Primary Endpoint: Change of Anaerobic threshold of 1.5ml/min/kg or more
Status: Completed
Last Updated: 10 years ago

Overview Investigators Eligibility Criteria Outcomes Sites Similar Trials

Overview

Brief Summary

This study will investigate the effect of preoperative chemoradiotherapy on exercise capacity as measured by cardiopulmonary exercise testing in patients with colorectal cancer.

Detailed Description

Chemoradiotherapy is associated with adverse effects. Patients with certain colorectal cancers undergo chemoradiotherapy prior to surgical resection. We intend to assess patient exercise capacity before and after chemoradiotherapy to assess whether this deteriorates. If there is a deleterious effect, this may affect operative outcome.

Registry

clinicaltrials.gov

Start Date

January 2009

End Date

October 2011

Last Updated

10 years ago

Study Type

Interventional

Study Design

Single Group

Sex

All

Investigators

Sponsor

Imperial College London

Responsible Party

Sponsor

Eligibility Criteria

Inclusion Criteria

•Age greater than 65
•Colorectal cancer requiring preoperative chemoradiotherapy

Exclusion Criteria

•Inability to walk, or exercise on a bicycle or treadmill
•Inability to understand instructions for CPET testing
•ASA grade 4 or 5 (indicating severe cardiovascular co-morbidity and not expected to survive surgery)
•Contraindications to Exercise Testing
•Myocardial infarction occurring 10 days or less before CPX testing
•Symptomatic arrythmias
•Left Main Stem coronary disease of \>50%
•Severe hypertension (SBP\>180mmHg)
•Resting SpO2 \<85%
•Acute cardiac inflammatory conditions (myocarditis, pericarditis)