MedPath

Endocrine Therapy With or Without Abemaciclib (LY2835219) Following Surgery in Participants With Breast Cancer

Phase 3
Active, not recruiting
Conditions
Breast Cancer
Interventions
Drug: Standard Adjuvant Endocrine Therapy
Registration Number
NCT03155997
Lead Sponsor
Eli Lilly and Company
Brief Summary

The purpose of this study is to evaluate the safety and efficacy of the study drug abemaciclib in participants with high risk, node positive, early stage, hormone receptor positive (HR+), human epidermal receptor 2 negative (HER2-), breast cancer.

Detailed Description

Not available

Recruitment & Eligibility

Status
ACTIVE_NOT_RECRUITING
Sex
All
Target Recruitment
5637
Inclusion Criteria
  • Women (regardless of menopausal status) or men ≥18 years of age (or per local regulations).

  • The participant has confirmed HR+, HER2-, early stage resected invasive breast cancer without evidence of distant metastases.

  • The participant must have undergone definitive surgery of the primary breast tumor.

  • The participant must have tumor tissue from breast (preferred) or lymph node for exploratory biomarker analysis available prior to randomization.

  • Pathologic lymph node involvement and at least one of the following indicating a higher risk of recurrence:

    • 4 or more positive axillary lymph nodes
    • Tumor size of at least 5 centimeters
    • Grade 3 defined as at least 8 points on the Bloom Richardson grading system
    • Ki-67 index by central analysis of ≥20% on untreated breast tissue
  • The participant must be randomized within 16 months from the time of definitive breast cancer surgery.

  • The participant may receive up to 12 weeks of endocrine therapy until randomization following the last non-endocrine therapy (surgery, chemotherapy, or radiation) whichever is last.

  • Participants must have recovered (grade ≤1) from the acute effects of chemotherapy and radiotherapy and from surgical side effects following definitive breast surgery.

  • Women of reproductive potential must have a negative blood pregnancy test and agree to use highly effective contraceptive methods.

  • The participant has a Eastern Cooperative Oncology Group (ECOG) performance status ≤1.

  • The participant has adequate organ function.

  • The participant is able to swallow oral medications.

Exclusion Criteria
  • Metastatic disease (including contralateral axillary lymph nodes) or node-negative disease.
  • Participants with inflammatory breast cancer.
  • Participants with a history of previous breast cancer, with the exception of ipsilateral ductal carcinoma in situ (DCIS) treated by locoregional therapy alone ≥5 years ago. Participants with a history of contralateral DCIS treated by local regional therapy at any time may be eligible. Participants with a history of any other cancer (except non-melanoma skin cancer or carcinoma in situ of the cervix), unless in complete remission with no therapy for a minimum of 5 years from the date of randomization are excluded.
  • Females who are pregnant or lactating.
  • The participant has previously received treatment with any CDK4 and CDK6 inhibitor.
  • The participant is receiving concurrent exogenous reproductive hormone therapy (for example, birth control pills, hormone replacement therapy, or megestrol acetate).
  • The participant has previously received endocrine therapy for breast cancer prevention (tamoxifen or aromatase inhibitors) or raloxifene.
  • The participant has serious preexisting medical condition(s) that, in the judgment of the investigator, would preclude participation in this study.
  • The participant has a personal history of any of the following conditions: syncope of cardiovascular etiology, ventricular arrhythmia of pathological origin or sudden cardiac arrest. Any participant with a history of venous thromboembolism (VTE).
  • The participant has active systemic infections or viral load.
  • The participant has received an experimental treatment in a clinical trial within the last 30 days or 5 half-lives, whichever is longer.

Study & Design

Study Type
INTERVENTIONAL
Study Design
PARALLEL
Arm && Interventions
GroupInterventionDescription
150 mg Abemaciclib + Endocrine TherapyStandard Adjuvant Endocrine TherapyParticipants received Abemaciclib orally at 150 milligrams (mg) twice daily with at least 6 hours between doses for up to 2 years or until evidence of disease recurrence or other discontinuation criteria were met, whichever occurs first. Endocrine therapy (physicians' choice) standard-of-care was administered according to package label until discontinuation criteria were met.
Endocrine TherapyStandard Adjuvant Endocrine TherapyEndocrine therapy (physicians' choice) standard-of-care was administered according to package label until discontinuation criteria were met.
150 mg Abemaciclib + Endocrine TherapyAbemaciclibParticipants received Abemaciclib orally at 150 milligrams (mg) twice daily with at least 6 hours between doses for up to 2 years or until evidence of disease recurrence or other discontinuation criteria were met, whichever occurs first. Endocrine therapy (physicians' choice) standard-of-care was administered according to package label until discontinuation criteria were met.
Primary Outcome Measures
NameTimeMethod
Invasive Disease Free Survival (IDFS)Baseline to Recurrence or Death from Any Cause (Up to 32 Months)

IDFS, as defined by the STEEP System, was measured from the date of randomization to the date of first occurrence of one of the following events: ipsilateral invasive breast tumor recurrence, regional invasive breast cancer recurrence, distant recurrence, contralateral invasive breast cancer, second primary non-breast invasive cancer, death attributable to any cause.

Secondary Outcome Measures
NameTimeMethod
IDFS for Participants With Ki-67 Index ≥20%Baseline to Recurrence or Death from Any Cause (Approximately 10 Years)

Outcome data will be provided after the study is completed.

Change From Baseline on the Functional Assessment of Cancer Therapy - Endocrine Symptoms (FACT-ES)Baseline, Follow Up (Approximately 3 Years)]

Outcome data will be provided after the study is completed.

Distant Relapse-Free Survival (DRFS)Baseline to Distant Recurrence or Death from Any Cause (Up to 32 Months)

Distant relapse-free survival is defined as the time from randomization to distant recurrence or death from any cause, whichever occurs first.

Overall Survival (OS)Baseline to Death from Any Cause (Approximately 10 Years)

Outcome data will be provided after the study is completed.

Change From Baseline on the EuroQol Five-Dimension Five-Level Questionnaire (EQ-5D-5L)Baseline, Follow Up (Approximately 3 Years)]

Outcome data will be provided after the study is completed.

Change From Baseline on the Functional Assessment of Chronic Illness Therapy - Fatigue (FACIT-F)Baseline, Follow Up (Approximately 3 Years)]

Outcome data will be provided after the study is completed.

Pharmacokinetics (PK): Minimum Steady State Concentration (Cmin,ss) of AbemaciclibDay 1 (2 hours post-dose), Days 30, 60, 90 post-dose

Pharmacokinetics (PK): Minimum Steady State Concentration (Cmin,ss) of Abemaciclib

Change From Baseline on the Functional Assessment of Cancer Therapy - Breast (FACT-B)Baseline, Follow Up (Approximately 3 Years)

Outcome data will be provided after the study is completed.

Trial Locations

Locations (605)

Millennium Oncology - Hollywood

🇺🇸

Hollywood, Florida, United States

Renown Regional Medical Center

🇺🇸

Reno, Nevada, United States

The Valley Hospital, Inc.

🇺🇸

Paramus, New Jersey, United States

The West Clinic, PLLC dba West Cancer Center

🇺🇸

Germantown, Tennessee, United States

IDIM - Instituto de Diagnóstico e Investigaciones Metabólicas

🇦🇷

Buenos Aires, Argentina

Instituto Alexander Fleming

🇦🇷

Ciudad Autónoma de Buenos Aires, Argentina

Epworth Hospital

🇦🇺

East Melbourne, Victoria, Australia

St John of God Subiaco Hospital

🇦🇺

Subiaco, Western Australia, Australia

Université Catholique de Louvain-Namur - Centre Hospitalier Universitaire Dinant-Godinne - Site Godinne

🇧🇪

Yvoir, Namur, Belgium

AZ Nikolaas

🇧🇪

Sint-Niklaas, Oost-Vlaanderen, Belgium

Clinical Chc Montlégia

🇧🇪

Liege, Wallonne, Région, Belgium

Clinique Saint Pierre

🇧🇪

Ottignies, Wallonne, Région, Belgium

Hospital São Lucas da PUCRS

🇧🇷

Porto Alegre, Rio Grande Do Sul, Brazil

Instituto de Educação, Pesquisa e Gestão em Saúde

🇧🇷

Rio de Janeiro, RJ, Brazil

Hospital Bruno Born

🇧🇷

Lajeado, RS, Brazil

Fundação Pio XII - Hospital de Câncer de Barretos

🇧🇷

Barretos, Sao Paulo, Brazil

Hospital de Base de São José do Rio Preto

🇧🇷

Sao Jose Rio Preto, Sao Paulo, Brazil

Instituto D'Or de Pesquisa e Ensino (IDOR)

🇧🇷

Sao Paulo, Brazil

Pérola Centro de Pesquisa em Oncologia

🇧🇷

São Paulo, Brazil

IBCC - Núcleo de Pesquisa e Ensino

🇧🇷

São Paulo, Brazil

Instituto de Assistência Médica ao Servidor Público Estadual - IAMSPE/HSPE-FMO Conhecer Centro de Oncolog -T

🇧🇷

São Paulo, Brazil

The Ottawa Hospital - General Campus

🇨🇦

Ottawa, Ontario, Canada

Humber River Hospital

🇨🇦

Toronto, Ontario, Canada

Hopital du Sacre-Coeur de Montreal

🇨🇦

Montreal, Quebec, Canada

Sun Yat-Sen University

🇨🇳

Guangzhou, Guangdong, China

Aarhus Universitetshospital, Skejby

🇩🇰

Aarhus, Midtjylland, Denmark

Centre Hospitalier Régional Universitaire de Brest - Hôpital Morvan

🇫🇷

Brest, Bretagne, France

Centre Eugène Marquis Rennes - Centre de Lutte Contre le Cancer

🇫🇷

Rennes, Ille-et-Vilaine, France

Institut de Cancérologie de l'Ouest

🇫🇷

Saint Herblain, Loire-Atlantique, France

Centre Jean Perrin - Centre Régional de Lutte contre le Cancer d'Auvergne

🇫🇷

Clermont-Ferrand, Puy-de-Dôme, France

Henri Mondor Hospital

🇫🇷

Creteil, Seine-et-Marne, France

Klinikum der Ludwig-Maximilians-Universitaet Muenchen

🇩🇪

München, Bayern, Germany

Klinikum Rechts Der Isar Der Technischen Universität München

🇩🇪

München, Bayern, Germany

Marien Hospital Witten

🇩🇪

Witten, Nordrhein-Westfalen, Germany

Mammazentrum HH - Krankenhaus Jerusalem

🇩🇪

Hamburg, Germany

University Hospital of Patras

🇬🇷

Patras, Achaia, Greece

Alexandra Hospital

🇬🇷

Athina, Attikí, Greece

Attikon General University Hospital

🇬🇷

Chaidari, Attikí, Greece

Grant Medical Foundation - Ruby Hall Clinic

🇮🇳

Pune, Maharashtra, India

Rambam Health Care Campus

🇮🇱

Haifa, Ḥeifā, Israel

Fondazione IRCCS San Gerardo dei Tintori

🇮🇹

Monza, Lombardia, Italy

Istituto Nazionale Tumori Regina Elena

🇮🇹

Rome, Roma, Italy

Ospedale Antonio Perrino

🇮🇹

Brindisi, Italy

Istituto Oncologico Veneto IRCCS

🇮🇹

Padova, Italy

Azienda Ospedaliero-Universitaria Città della Salute e della Scienza di Torino

🇮🇹

Torino, Italy

APSS - Presidio Ospedaliero Santa Chiara

🇮🇹

Trento, Italy

Hyogo College of Medecine

🇯🇵

Nishinomiya, Hyogo, Japan

St Marianna University School of Medicine Hospital

🇯🇵

Kawasaki, Kanagawa, Japan

Kindai University Hospital- Osakasayama Campus

🇯🇵

Osaka Sayama-shi, Osaka, Japan

Saitama Prefectural Cancer Center

🇯🇵

Ina-machi, Saitama, Japan

Shizuoka Cancer Center

🇯🇵

Nagaizumi, Shizuoka, Japan

National Hospital Organization Osaka Medical Center

🇯🇵

Osaka, Japan

Soon chun hyang University Cheonan Hospital

🇰🇷

Cheonan-si, Chungcheongnam-do [Chungnam], Korea, Republic of

Kyungpook National University Chilgok Hospital

🇰🇷

Daegu, Taegu-Kwangyǒkshi, Korea, Republic of

Hospital Civil Fray Antonio Alcalde

🇲🇽

Guadalajara, Jalisco, Mexico

Centro Regiomontano de Investigacion

🇲🇽

Monterrey, Nuevo Leon, Mexico

Private Practice - Dr. Joaquin Reinoso

🇲🇽

Monterrey, Nuevo León, Mexico

Centro de Estudios y Prevencion del Cancer

🇲🇽

Juchitan, Oaxaca, Mexico

Centro Hemato Oncologico Privado

🇲🇽

Toluca de Lerdo, Toluca, Mexico

Unidad de Investigacion en Salud

🇲🇽

Chihuahua, Mexico

Haga Ziekenhuis locatie Leyweg

🇳🇱

Den Haag, Zuid-Holland, Netherlands

Albert Schweitzer Ziekenhuis, locatie Dordwijk

🇳🇱

Dordrecht, Zuid-Holland, Netherlands

Centrum Onkologii Ziemii Lubelskiej

🇵🇱

Lublin, Lubelskie, Poland

Narodowy Instytut Onkologii im. Marii Sklodowskiej-Curie - Panstwowy Instytut Badawczy w Warszawie

🇵🇱

Warszawa, Mazowieckie, Poland

Opolskie Centrum Onkologii w Opolu im. prof. Tadeusza Koszarowskiego

🇵🇱

Opole, Opolskie, Poland

Olsztyński Ośrodek Onkologiczny Kopernik

🇵🇱

Olsztyn, Warmińsko-mazurskie, Poland

Wielkopolskie Centrum Onkologii

🇵🇱

Poznan, Wielkopolskie, Poland

Centrum Terapii Wspolczesnej J. M. Jasnorzewska Spolka Komandytowo-Akcyjna

🇵🇱

Lodz, Łódzkie, Poland

Instituto Portugês de Oncologia de Coimbra Francisco Gentil

🇵🇹

Coimbra, Portugal

Champalimaud Foundation

🇵🇹

Lisboa, Portugal

Centro Hospitalar Lisboa Norte, E.P.E. - Hospital de Santa Maria

🇵🇹

Lisboa, Portugal

Institutul Oncologic

🇷🇴

Cluj-Napoca, Cluj, Romania

Centrul de Oncologie "Sfântul Nectarie"

🇷🇴

Craiova, Dolj, Romania

Radiology Therapeutic Center

🇷🇴

Otopeni, Ilfov, Romania

Oncopremium Team

🇷🇴

Baia Mare, Maramureș, Romania

Samara Regional Clinical Oncology Center

🇷🇺

Samara, Samarskaya Oblast', Russian Federation

St. Petersburg City Oncological Dispensary - Berezovaya Avenue

🇷🇺

Saint-Petersburg, Sankt-Peterburg, Russian Federation

Saint-Petersburg Scientific-Practical Center of Specialized Kinds of Medical Care (oncological) named afte -T

🇷🇺

St. Petersburg, Sankt-Peterburg, Russian Federation

Volgograd Regional Oncological Dispensary No. 3

🇷🇺

Volzhsky, Volgogradskaya Oblast', Russian Federation

Yaroslavl Regional Cancer Hospital

🇷🇺

Yaroslavl, Yaroslavskaya Oblast', Russian Federation

Hospital Universitario Arnau de Vilanova de Lleida

🇪🇸

Lleida, Lleida [Lérida], Spain

Hospital Clínico de Valencia

🇪🇸

Valencia, Valenciana, Comunitat, Spain

Hospital Universitario San Cecilio

🇪🇸

Granada, Spain

Complejo Hospitalario de Jaén

🇪🇸

Jaen, Spain

Hospital Universitario de Salamanca - Complejo Asistencial Universitario de Salamanca

🇪🇸

Salamanca, Spain

Ege University Medicine of Faculty

🇹🇷

Bornova, Izmir, Turkey

Ankara Gülhane Eitim ve Aratrma Hastanesi

🇹🇷

Ankara, Kecioren, Turkey

Abdurrahman Yurtaslan Ankara Oncology, education and Research Hospital

🇹🇷

Ankara, Turkey

İnönü Üniversitesi Turgut Özal Tıp Merkezi

🇹🇷

Malatya, Turkey

The Royal Cornwall Hospital

🇬🇧

Truro, England, United Kingdom

Guy's & St Thomas' NHS Foundation Trust

🇬🇧

London, London, City Of, United Kingdom

University of Alabama Birmingham

🇺🇸

Birmingham, Alabama, United States

Providence Alaska Medical Center

🇺🇸

Anchorage, Alaska, United States

Banner MD Anderson Cancer Center

🇺🇸

Gilbert, Arizona, United States

Arizona Oncology Associates, P.C. - HOPE

🇺🇸

The Woodlands, Texas, United States

St. Joseph's Hospital and Medical Center

🇺🇸

Phoenix, Arizona, United States

Mayo Clinic Hospital

🇺🇸

Phoenix, Arizona, United States

The University of Arizona Cancer Center

🇺🇸

Tucson, Arizona, United States

Yuma Regional Cancer Center

🇺🇸

Yuma, Arizona, United States

St. Bernards Medical Center

🇺🇸

Jonesboro, Arkansas, United States

Highlands Oncology Group

🇺🇸

Springdale, Arkansas, United States

Beverly Hills Cancer Center

🇺🇸

Beverly Hills, California, United States

Roy and Patricia Disney Family Cancer Center - Providence Saint Joseph Medical Center

🇺🇸

Burbank, California, United States

City of Hope National Medical Center

🇺🇸

Duarte, California, United States

California Cancer Associates Research and Excellence

🇺🇸

Fresno, California, United States

Kaiser Permanente

🇺🇸

Vallejo, California, United States

Loma Linda University School of Medicine

🇺🇸

Loma Linda, California, United States

Cedars-Sinai Medical Center

🇺🇸

Los Angeles, California, United States

Pacific Cancer Care

🇺🇸

Monterey, California, United States

St. Joseph Hospital

🇺🇸

Orange, California, United States

University of California Davis (UC Davis) Comprehensive Cancer Center

🇺🇸

Sacramento, California, United States

UCSF Medical Center at Mission Bay

🇺🇸

San Francisco, California, United States

California Cancer Associates in Research and Excellence

🇺🇸

San Marcos, California, United States

Dignity Health Dominican Oncology and Hematology

🇺🇸

Santa Cruz, California, United States

USO-Rocky Mountain Cancer Center

🇺🇸

The Woodlands, Texas, United States

Yale-New Haven Hospital

🇺🇸

New Haven, Connecticut, United States

Florida Cancer Specialists - South

🇺🇸

Fort Myers, Florida, United States

University of Florida College of Medicine

🇺🇸

Gainesville, Florida, United States

Mayo Clinic in Florida

🇺🇸

Jacksonville, Florida, United States

Cancer Specialists of North Florida

🇺🇸

Jacksonville, Florida, United States

Florida Cancer Specialists - North

🇺🇸

Lecanto, Florida, United States

Ocala Oncology, P.A.

🇺🇸

Ocala, Florida, United States

Tallahassee Memorial Cancer Center

🇺🇸

Tallahassee, Florida, United States

Moffitt Cancer Center, Richard M. Shulze Family Foundation Outpatient Center

🇺🇸

Tampa, Florida, United States

University Cancer & Blood Center, LLC

🇺🇸

Athens, Georgia, United States

Northside Hospital

🇺🇸

Atlanta, Georgia, United States

Northwest Georgia Oncology Centers, a Service of Wellstar Cobb Hospital

🇺🇸

Marietta, Georgia, United States

Summit Cancer Care DBA Candler Medical Oncology Practice

🇺🇸

Savannah, Georgia, United States

University of Hawaii Cancer Center

🇺🇸

Honolulu, Hawaii, United States

John H. Stroger Hospital of Cook County

🇺🇸

Chicago, Illinois, United States

Rush University Medical Center

🇺🇸

Chicago, Illinois, United States

Edward Cancer Center

🇺🇸

Naperville, Illinois, United States

Quincy Medical Group

🇺🇸

Quincy, Illinois, United States

Franciscan St. Francis Health

🇺🇸

Indianapolis, Indiana, United States

Community Howard Oncology Center

🇺🇸

Kokomo, Indiana, United States

Cancer Center of Kansas

🇺🇸

Wichita, Kansas, United States

Univ of Louisville School of Medicine

🇺🇸

Louisville, Kentucky, United States

Mary Bird Perkins Cancer Center - Baton Rouge

🇺🇸

Baton Rouge, Louisiana, United States

Terrebonne General Medical Center

🇺🇸

Houma, Louisiana, United States

Cancer Care of Maine

🇺🇸

Brewer, Maine, United States

New England Cancer Specialists - Kennebunk

🇺🇸

Kennebunk, Maine, United States

Central Maine Medical Center

🇺🇸

Lewiston, Maine, United States

Meritus John Marsh Cancer Center

🇺🇸

Hagerstown, Maryland, United States

Dana-Farber Cancer Institute

🇺🇸

Boston, Massachusetts, United States

Reliant Medical Group, Inc.

🇺🇸

Worcester, Massachusetts, United States

Mayo Clinic in Rochester, Minnesota

🇺🇸

Rochester, Minnesota, United States

Jackson Oncology Associates PLLC

🇺🇸

Jackson, Mississippi, United States

HCA Midwest Kansas City, MidAmerica Division, Inc.

🇺🇸

Kansas City, Missouri, United States

Cancer Alliance of Nebraska

🇺🇸

Omaha, Nebraska, United States

Nebraska Methodist Hospital

🇺🇸

Omaha, Nebraska, United States

Tennessee Cancer Specialists

🇺🇸

Knoxville, Tennessee, United States

Dartmouth Hitchcock Medical Center

🇺🇸

Lebanon, New Hampshire, United States

Memorial Sloan Kettering - Basking Ridge

🇺🇸

Basking Ridge, New Jersey, United States

Summit Medical Group Cancer Center

🇺🇸

Florham Park, New Jersey, United States

Newark Beth Israel Medical Center

🇺🇸

Newark, New Jersey, United States

Community Medical Center

🇺🇸

Toms River, New Jersey, United States

Broome Oncology

🇺🇸

Binghamton, New York, United States

Weill Cornell Medical College

🇺🇸

New York, New York, United States

Vassar Brothers Medical Center

🇺🇸

Poughkeepsie, New York, United States

SUNY At Stony Brook

🇺🇸

Stony Brook, New York, United States

White Plains Hospital

🇺🇸

White Plains, New York, United States

WakeMed Cancer Care - Waverly Hematology & Medical Oncology

🇺🇸

Cary, North Carolina, United States

Margaret R. Pardee Memorial Hospital

🇺🇸

Hendersonville, North Carolina, United States

Wake Forest University Health Sciences

🇺🇸

Winston-Salem, North Carolina, United States

Aultman Hospital

🇺🇸

Canton, Ohio, United States

University Hospitals Cleveland Medical Center

🇺🇸

Cleveland, Ohio, United States

Cleveland Clinic Foundation

🇺🇸

Cleveland, Ohio, United States

Columbus Community Clinical Oncology Program

🇺🇸

Columbus, Ohio, United States

Asante Rogue Regional Medical Center

🇺🇸

Medford, Oregon, United States

Oregon Health and Science University

🇺🇸

Portland, Oregon, United States

Abington Medical Specialists

🇺🇸

Abington, Pennsylvania, United States

St. Luke's Hospital & Health Network

🇺🇸

Bethlehem, Pennsylvania, United States

Albert Einstein Healthcare Network

🇺🇸

Philadelphia, Pennsylvania, United States

AHN Allegheny General Hospital

🇺🇸

Pittsburgh, Pennsylvania, United States

NSABP Foundation

🇺🇸

Pittsburgh, Pennsylvania, United States

PinnacleHealth Cancer Institute

🇺🇸

Pittsburgh, Pennsylvania, United States

Univ of Pittsburgh Cancer Inst. (UPCI)

🇺🇸

Pittsburgh, Pennsylvania, United States

WellSpan Health/York Cancer Center Oncology Research

🇺🇸

York, Pennsylvania, United States

McLeod Regional Medical Center

🇺🇸

Florence, South Carolina, United States

St Francis Cancer Center

🇺🇸

Greenville, South Carolina, United States

Spartanburg Regional Medical Center

🇺🇸

Spartanburg, South Carolina, United States

Sanford USD Medical Center

🇺🇸

Sioux Falls, South Dakota, United States

Erlanger Health System

🇺🇸

Chattanooga, Tennessee, United States

Chattanooga Research and Medicine

🇺🇸

Chattanooga, Tennessee, United States

Urology Associates of Kingsport

🇺🇸

Kingsport, Tennessee, United States

University of Tennessee Medical Center

🇺🇸

Knoxville, Tennessee, United States

Baptist Cancer Center

🇺🇸

Memphis, Tennessee, United States

Florida Cancer Specialists

🇺🇸

Nashville, Tennessee, United States

Sarah Cannon Cancer Center

🇺🇸

Nashville, Tennessee, United States

Tennessee Oncology Nashville

🇺🇸

Nashville, Tennessee, United States

Texas Oncology Cancer Care and Research Center

🇺🇸

The Woodlands, Texas, United States

Texas Oncology-Baylor Charles A. Sammons Cancer Center

🇺🇸

The Woodlands, Texas, United States

University of Texas Southwestern Medical Center at Dallas

🇺🇸

Dallas, Texas, United States

Texas Oncology Fort Worth

🇺🇸

The Woodlands, Texas, United States

Oncology Consultants, P.A.

🇺🇸

Houston, Texas, United States

Texas Oncology P.A.

🇺🇸

The Woodlands, Texas, United States

University of Texas Health Science Center - San Antonio

🇺🇸

San Antonio, Texas, United States

Comprehensive Cancer Centers of Nevada

🇺🇸

The Woodlands, Texas, United States

Illinois Cancer Specialists

🇺🇸

The Woodlands, Texas, United States

Miami Cancer Institute at Baptist Health, Inc.

🇺🇸

The Woodlands, Texas, United States

Minnesota Oncology/Hematology PA

🇺🇸

The Woodlands, Texas, United States

Northwest Cancer Specialists PC

🇺🇸

The Woodlands, Texas, United States

Oncology and Hematology Associates of Southwest Virginia Inc

🇺🇸

The Woodlands, Texas, United States

Oncology Hematology Care Inc

🇺🇸

The Woodlands, Texas, United States

Oncology Hematology West

🇺🇸

The Woodlands, Texas, United States

Sansum Clinic

🇺🇸

The Woodlands, Texas, United States

Shenandoah Oncology, P.C.

🇺🇸

The Woodlands, Texas, United States

Texas Oncology - Dallas Presbyterian Hospital

🇺🇸

The Woodlands, Texas, United States

Texas Oncology - Denison

🇺🇸

The Woodlands, Texas, United States

Texas Oncology - McAllen

🇺🇸

The Woodlands, Texas, United States

Texas Oncology - McKinney

🇺🇸

The Woodlands, Texas, United States

Texas Oncology - Medical City Dallas

🇺🇸

The Woodlands, Texas, United States

Texas Oncology - Methodist Dallas Cancer Center

🇺🇸

The Woodlands, Texas, United States

Texas Oncology - Paris

🇺🇸

Tyler, Texas, United States

Texas Oncology - San Antonio Medical Center

🇺🇸

The Woodlands, Texas, United States

Texas Oncology - The Woodlands

🇺🇸

The Woodlands, Texas, United States

Texas Oncology - Tyler

🇺🇸

Tyler, Texas, United States

Texas Oncology - West Texas

🇺🇸

The Woodlands, Texas, United States

Texas Oncology Denton

🇺🇸

The Woodlands, Texas, United States

Texas Oncology- Mesquite

🇺🇸

The Woodlands, Texas, United States

Texas Oncology-Arlington South

🇺🇸

The Woodlands, Texas, United States

Texas Oncology-Deke Slayton Cancer Center

🇺🇸

The Woodlands, Texas, United States

Texas Oncology-Plano East

🇺🇸

The Woodlands, Texas, United States

Texas Oncology-Plano West

🇺🇸

The Woodlands, Texas, United States

US Oncology

🇺🇸

The Woodlands, Texas, United States

USO - Texas Oncology, P. A.

🇺🇸

The Woodlands, Texas, United States

USO-Maryland Oncology Hematology, P.A.

🇺🇸

The Woodlands, Texas, United States

USO-New York Oncology Hematology, P.C

🇺🇸

The Woodlands, Texas, United States

USO-Southern Cancer Center, P.C.

🇺🇸

The Woodlands, Texas, United States

USO-Virginia Oncology Associates

🇺🇸

The Woodlands, Texas, United States

Virginia Cancer Specialists

🇺🇸

The Woodlands, Texas, United States

Willamette Valley Cancer Institute & Research Ctr.

🇺🇸

The Woodlands, Texas, United States

Utah Cancer Specialists

🇺🇸

Salt Lake City, Utah, United States

The University of Vermont Medical Center Inc.

🇺🇸

Burlington, Vermont, United States

Hematology Oncology Associates of Fredericksburg Inc.

🇺🇸

Fredericksburg, Virginia, United States

Virginia Commonwealth University (VCU) Medical Center

🇺🇸

Richmond, Virginia, United States

MultiCare Regional Cancer Center - Auburn

🇺🇸

Auburn, Washington, United States

Swedish Medical Center

🇺🇸

Seattle, Washington, United States

Centro de Oncologia e Investigacion Buenos Aires

🇦🇷

Berazategui, Buenos Aires, Argentina

Instituto de Investigaciones Clinicas Mar del Plata

🇦🇷

Mar del Plata, Buenos Aires, Argentina

Hospital Universitario Austral

🇦🇷

Pilar, Buenos Aires, Argentina

Fundacion CENIT para la Investigacion en Neurociencias

🇦🇷

Caba, Ciudad Autonoma Buenos Aires, Argentina

Hospital Aleman

🇦🇷

Buenos Aires, Ciudad Autónoma De Buenos Aires, Argentina

Clinica Viedma

🇦🇷

Viedma, Rio Negro, Argentina

Instituto de Oncologia de Rosario

🇦🇷

Rosario, Santa Fe, Argentina

Centro Para la Atención Integral del Paciente Oncologico (CAIPO)

🇦🇷

San Miguel de Tucuman, Tucumán, Argentina

Clinica Adventista de Belgrano

🇦🇷

Ciudad Autonoma Buenos Aires, Argentina

Fundación CORI para la Investigación y Prevención del Cáncer

🇦🇷

La Rioja, Argentina

Consultorio Dr. Miguel Ángel Escudero

🇦🇷

Salta, Argentina

CER San Juan

🇦🇷

San Juan, Argentina

Centro Medico San Roque

🇦🇷

Tucuman, Argentina

Chris O'Brien Lifehouse

🇦🇺

Camperdown, New South Wales, Australia

St Vincent's Hospital

🇦🇺

Darlinghurst, New South Wales, Australia

Lismore Base Hospital

🇦🇺

Lismore, New South Wales, Australia

Liverpool Hospital

🇦🇺

Liverpool, New South Wales, Australia

Mater Hospital Sydney

🇦🇺

Sydney, New South Wales, Australia

Calvary Mater Newcastle

🇦🇺

Waratah, New South Wales, Australia

Westmead Hospital

🇦🇺

Westmead, New South Wales, Australia

Southern Medical Day Care Centre

🇦🇺

Wollongong, New South Wales, Australia

Mater Misericordiae Limited

🇦🇺

Brisbane, Queensland, Australia

Gold Coast University Hospital

🇦🇺

Southport, Queensland, Australia

The Townsville Hospital

🇦🇺

Townsville, Queensland, Australia

Lyell McEwin Hospital

🇦🇺

Elizabeth Vale, South Australia, Australia

Ashford Cancer Centre Research

🇦🇺

Kurralta Park, South Australia, Australia

Launceston General Hospital

🇦🇺

Launceston, Tasmania, Australia

Box Hill Hospital

🇦🇺

Box Hill, Victoria, Australia

Peter MacCallum Cancer Centre

🇦🇺

Melbourne, Victoria, Australia

Maroondah Hospital

🇦🇺

Melbourne, Victoria, Australia

Breast Cancer Research Centre WA

🇦🇺

Nedlands, Western Australia, Australia

Medizinische Universität Graz

🇦🇹

Graz, Steiermark, Austria

Medizinische Universitaet Innsbruck

🇦🇹

Innsbruck, Tirol, Austria

Private Practice - Dr. Hubalek

🇦🇹

Schwaz, Tirol, Austria

Medizinische Universität Wien

🇦🇹

Vienna, Wien, Austria

Universitaetsklinikum Allgemeines Krankenhaus Wien

🇦🇹

Vienna, Wien, Austria

Klinik Hietzing

🇦🇹

Vienna, Wien, Austria

Universitätsklinikum Salzburg

🇦🇹

Salzburg, Austria

Algemeen Ziekenhuis klina

🇧🇪

Brasschaat, Antwerpen, Belgium

Antwerp University Hospital

🇧🇪

Edegem, Antwerpen, Belgium

Cliniques Universitaires Saint-Luc

🇧🇪

Brussels, Bruxelles-Capitale, Région De, Belgium

CHU de Charleroi - Hopital Civil Marie Curie

🇧🇪

Lodelinsart, Hainaut, Belgium

Jessa Ziekenhuis

🇧🇪

Hasselt, Limburg, Belgium

Centre Hospitalier Universitaire de Liège - Domaine Universitaire du Sart Tilman

🇧🇪

Liege, Liège, Belgium

Centre Hospitalier D'Ardenne - Forget

🇧🇪

Libramont, Luxembourg, Belgium

UZ Leuven

🇧🇪

Leuven, Vlaams-Brabant, Belgium

Groupe Jolimont

🇧🇪

La Louvière, Wallonne, Région, Belgium

AZ Sint-Jan Brugge-Oostende AV

🇧🇪

Brugge, West-Vlaanderen, Belgium

Jan Yperman ziekenhuis

🇧🇪

Ieper, West-Vlaanderen, Belgium

AZ Groeninge Campus Kennedylaan

🇧🇪

Kortrijk, West-Vlaanderen, Belgium

CHU UCL Namur/Site Sainte Elisabeth

🇧🇪

Namur, Belgium

Centro de Pesquisa Clínica do Instituto do Câncer do Ceará

🇧🇷

Fortaleza, Ceara, Brazil

Sírio-Libanês Brasilia-Centro de Oncologia-Asa Sul

🇧🇷

Brasilia, District Federal, Brazil

Hospital Araújo Jorge

🇧🇷

Goiania, Goias, Brazil

Hospital de Cancer de Londrina

🇧🇷

Londrina, Parana, Brazil

CIONC - Centro Integrado de Oncologia de Curitiba

🇧🇷

Curitiba, Paraná, Brazil

ONCOSITE - Centro de Pesquisa Clinica em Oncologia

🇧🇷

Ijui, Rio Grande Do Sul, Brazil

Instituto do Cancer do Estado de Sao Paulo - ICESP

🇧🇷

São Paulo, SP, Brazil

Hospital de Clínicas de Ribeirão Preto

🇧🇷

Ribeirao Preto, São Paulo, Brazil

Faculdade de Medicina do ABC

🇧🇷

Santo André, São Paulo, Brazil

INCA - Instituto Nacional Do Cancer

🇧🇷

Rio De Janeiro, Brazil

Hospital Sírio Libanês

🇧🇷

São Paulo, Brazil

North York General Hospital

🇨🇦

Toronto, Ontario, Canada

Unity Health Toronto, St. Michael's Hospital

🇨🇦

Toronto, Ontario, Canada

Centre Hospitalier de l'Universite de Montreal

🇨🇦

Montreal, Quebec, Canada

Jewish General Hospital

🇨🇦

Montreal, Quebec, Canada

CHU de Quebec-Hopital de Saint-Sacrement

🇨🇦

Quebec City, Quebec, Canada

Centre intégré universitaire de santé et de services sociaux de l'Estrie - Centre Hospitalier Universitair -T

🇨🇦

Sherbrooke, Quebec, Canada

The Fifth Medical Center of PLA General Hospital

🇨🇳

Beijing, Beijing, China

Beijing Cancer Hospital

🇨🇳

Beijing, Beijing, China

Fujian Medical University Union Hospital-1 Bingfanglou

🇨🇳

Fuzhou, Fujian, China

Guangdong Provincial People's Hospital

🇨🇳

Guangzhou, Guangdong, China

The First Affiliated Hospital, Sun-Yat Sen University

🇨🇳

Guangzhou, Guangdong, China

Harbin Medical University Cancer Hospital

🇨🇳

Harbin, Heilongjiang, China

Henan Cancer Hospital

🇨🇳

Zhengzhou, Henan, China

Hunan Cancer Hospital

🇨🇳

Changsha, Hunan, China

Jiangsu Cancer Hospital

🇨🇳

Nanjing, Jiangsu, China

Jiangsu Province Hospital

🇨🇳

Nanjing, Nanjing, China

Shandong Cancer Hospital

🇨🇳

Jinan, Shandong, China

Shanghai Jiaotong University School of Medicine Ruijin Hospital

🇨🇳

Shanghai, Shanghai, China

Fudan University Shanghai Cancer Center

🇨🇳

Shanghai, Shanghai, China

Zhejiang Cancer Hospital

🇨🇳

Hangzhou, Zhejiang, China

The Second Affiliated Hospital of Zhejiang University School of Medicine

🇨🇳

Hangzhou, Zhejiang, China

Nemocnice Horovice

🇨🇿

Horovice, Beroun, Czechia

Masarykuv onkologicky ustav

🇨🇿

Brno, Brno-město, Czechia

Fakultni Nemocnice Ostrava

🇨🇿

Ostrava, Moravskoslezský Kraj, Czechia

Multiscan

🇨🇿

Pardubice, Pardubický Kraj, Czechia

Fakultni Thomayerova nemocnice

🇨🇿

Prague, Praha 4, Czechia

FN Plzen Lochotin

🇨🇿

Plzen, Czechia

Herlev and Gentofte Hospital

🇩🇰

Copenhagen, Hovedstaden, Denmark

Rigshospitalet

🇩🇰

København Ø, Hovedstaden, Denmark

Regionshospitalet Herning

🇩🇰

Herning, Midtjylland, Denmark

Aalborg Universitetshospital, Syd

🇩🇰

Aalborg, Nordjylland, Denmark

Næstved Sygehus

🇩🇰

Næstved, Sjælland, Denmark

Sydvestjysk Sygehus Esbjerg

🇩🇰

Esbjerg, Syddanmark, Denmark

Odense Universitetshospital

🇩🇰

Odense, Syddanmark, Denmark

Sygehus Soenderjylland

🇩🇰

Soenderborg, Syddanmark, Denmark

Vejle Sygehus

🇩🇰

Vejle, Syddanmark, Denmark

Keski-Suomen Keskussairaala

🇫🇮

Jyväskylä, Mellersta Finland, Finland

Tampereen yliopistollinen sairaala

🇫🇮

Tampere, Pirkanmaa, Finland

Vaasan Keskussairaala

🇫🇮

Vaasa, Pohjanmaa, Finland

Oulun yliopistollinen sairaala

🇫🇮

Oulu, Pohjois-Pohjanmaa, Finland

Kuopion Yliopistollinen Sairaala

🇫🇮

Kuopio, Pohjois-Savo, Finland

Satakunnan Keskussairaala

🇫🇮

Pori, Satakunta, Finland

Docrates Syöpäsairaala

🇫🇮

Helsinki, Uusimaa, Finland

Turku University Central Hospital

🇫🇮

Turku, Varsinais-Suomi, Finland

Päijät-Häme Central hospital

🇫🇮

Lahti, Finland

Polyclinique De Blois

🇫🇷

La Chaussee Saint Victor, Centre, France

Centre Georges Francois Leclerc

🇫🇷

Dijon, Côte-d'Or, France

Hôpital Privé des Côtes d'Armor- HPCA

🇫🇷

Plérin, Côtes-d'Armor, France

CHU de Besancon Hopital Jean Minjoz

🇫🇷

Besancon, Doubs, France

Centre de Cancérologie du Grand Montpellier

🇫🇷

Montpellier, Languedoc-Roussillon, France

Polyclinique de Gentilly

🇫🇷

Nancy, Meurthe-et-Moselle, France

Clinique Victor Hugo Le Mans

🇫🇷

Le Mans, Pays-de-la-Loire, France

Centre Leon Berard

🇫🇷

Lyon, Rhône-Alpes, France

Centre de Lutte Contre le Cancer - Centre Henri Becquerel Normandie Rouen

🇫🇷

Rouen, Seine-Maritime, France

Sainte Catherine Institut du Cancer Avignon Provence

🇫🇷

Avignon, Vaucluse, France

Centre Hospitalier de Vendee Les Oudairies

🇫🇷

La Roche Sur Yon, Vendée, France

Institut Curie

🇫🇷

Paris CEDEX 05, France

Praxis für interdisziplinäre Onkologie & Hämatologie

🇩🇪

Freiburg im Breisgau, Baden-Württemberg, Germany

Universitätsklinikum Freiburg

🇩🇪

Freiburg, Baden-Württemberg, Germany

Private Practice - Dr. Helmut Oettle und Prof.Dr.med. Frank Mayer

🇩🇪

Friedrichshafen, Baden-Württemberg, Germany

Klinikum Ludwigsburg

🇩🇪

Ludwigsburg, Baden-Württemberg, Germany

Universitätsklinikum Tübingen

🇩🇪

Tübingen, Baden-Württemberg, Germany

Universitätsklinikum Ulm

🇩🇪

Ulm, Baden-Württemberg, Germany

Klinikum St. Marien Amberg

🇩🇪

Amberg, Bayern, Germany

Gemeinschaftspraxis hop-augsburg

🇩🇪

Augsburg, Bayern, Germany

Universitätsklinikum Erlangen

🇩🇪

Erlangen, Bayern, Germany

Rotkreuzklinikum München gemeinnützige GmbH

🇩🇪

München, Bayern, Germany

Agaplesion Markus Krankenhaus

🇩🇪

Frankfurt, Hessen, Germany

Sana Klinikum Offenbach

🇩🇪

Offenbach, Hessen, Germany

Private Practice - Dres. Andreas Köhler und Roswitha Fuchs

🇩🇪

Langen, Hesse, Germany

Franziskus-Hospital Harderberg

🇩🇪

Georgsmarienhütte, Niedersachsen, Germany

Gynäkologisch-Onkologische Praxis am Pelikanplatz

🇩🇪

Hannover, Niedersachsen, Germany

Medizinische Hochschule Hannover

🇩🇪

Hannover, Niedersachsen, Germany

Universitätsklinikum Bonn

🇩🇪

Bonn, Nordrhein-Westfalen, Germany

Universitätsklinikum Düsseldorf

🇩🇪

Düsseldorf, Nordrhein-Westfalen, Germany

Kliniken Essen-Mitte, Evangelische Huyssens-Stiftung

🇩🇪

Essen, Nordrhein-Westfalen, Germany

Zentrum fuer ambulante gynaekologische Onkologie (ZAGO)

🇩🇪

Krefeld, Nordrhein-Westfalen, Germany

Evangelisches Krankenhaus Bethesda Mönchengladbach gGmbH

🇩🇪

Mönchengladbach, Nordrhein-Westfalen, Germany

Universitätsklinikum Münster - Albert Schweitzer Campus

🇩🇪

Münster, Nordrhein-Westfalen, Germany

Universitätsklinikum Carl Gustav Carus

🇩🇪

Dresden, Sachsen, Germany

Universitaetsklinikum Schleswig-Holstein Campus Kiel

🇩🇪

Kiel, Schleswig-Holstein, Germany

SRH Wald-Klinikum Gera gGmbH

🇩🇪

Gera, Thüringen, Germany

Helios Klinikum Berlin-Buch

🇩🇪

Berlin, Germany

Medizinisches Versorgungszentrum Onkologischer Schwerpunkt am Oskar-Helene-Heim

🇩🇪

Berlin, Germany

Kath. Marienkrankenhaus gGmbH

🇩🇪

Hamburg, Germany

Asklepios Kliniken Hamburg

🇩🇪

Hamburg, Germany

Errikos Dunant Hospital Center

🇬🇷

Athens, Attikí (Region), Greece

Agios Savvas Regional Cancer Hospital

🇬🇷

Athens, Attikí, Greece

Metropolitan Hospital

🇬🇷

Athens, Attikí, Greece

General Oncology Hospital of Kifissia "Agioi Anargiroi"

🇬🇷

Nea Kifissia, Attikí, Greece

Bioclinic of Thessaloniki

🇬🇷

Thessaloniki, Kentrikí Makedonía, Greece

University General Hospital of Heraklion

🇬🇷

Heraklion, Krítí, Greece

European Interbalkan Medical Center

🇬🇷

Thessaloniki, Thessaloníki, Greece

Euromedica - General Clinic of Thessaloniki

🇬🇷

Thessaloniki, Greece

Papageorgiou General Hospital of Thessaloniki

🇬🇷

Thessaloniki, Greece

University Hospital of Ioannina

🇬🇷

Ioannina, Ípeiros, Greece

Pamela Youde Nethersole Eastern Hospital

🇭🇰

Chai Wan, Hong Kong

Queen Mary Hospital

🇭🇰

Hksar, Hong Kong

Tuen Mun Hospital

🇭🇰

Tuen Mun, Hong Kong

Queen Elizabeth Hospital

🇭🇰

Yau Ma Tei, Hong Kong

Bacs-Kiskun Varmegyei Oktatokorhaz

🇭🇺

Kecskemet, Bacs-Kiskun, Hungary

Jasz-Nagykun-Szolnok Megyei Hetenyi Geza Korhaz

🇭🇺

Szolnok, Jász-Nagykun-Szolnok, Hungary

Szent Margit Kórház

🇭🇺

Budapest, Hungary

Magyar Honvedseg Egeszsegugyi Kozpont

🇭🇺

Budapest, Hungary

Semmelweis University

🇭🇺

Budapest, Hungary

Szent Imre Egyetemi Oktatokorhaz

🇭🇺

Budapest, Hungary

Uzsoki Utcai Kórház

🇭🇺

Budapest, Hungary

MNJ Institute of Oncology

🇮🇳

Hyderabad, Andhra Pradesh, India

Dr. B. L. Kapur Memorial Hospital

🇮🇳

New Delhi, Delhi, India

HCG Cancer Centre

🇮🇳

Vadodara, Gujarat, India

Artemis Hospital

🇮🇳

Gurgaon, Haryana, India

Manipal Hospital

🇮🇳

Bangalore, Karmnataka, India

Regional Cancer Centre

🇮🇳

Trivandrum, Kerala, India

Tata Memorial Hospital

🇮🇳

Mumbai, Maharashtra, India

HCG Manavata Cancer Centre

🇮🇳

Nasik, Maharashtra, India

Deenanth Mangeshkar Hospital and Research Centre

🇮🇳

Pune, Maharashtra, India

Apollo Speciality Hospital - Teynampet

🇮🇳

Chennai, Tamil Nadu, India

Apollo Gleneagles Hospitals

🇮🇳

Kolkata, West Bengal, India

Medica Superspecialty Hospital

🇮🇳

Kolkata, West Bengal, India

Post Graduate Institute of Medical Education & Research

🇮🇳

Chandigarh, India

Meir Medical Center

🇮🇱

Kfar Saba, HaMerkaz, Israel

Soroka Medical Center

🇮🇱

Beer Sheva, HaDarom, Israel

Rabin Medical Center

🇮🇱

Petach Tikva, HaMerkaz, Israel

Sheba Medical Center

🇮🇱

Ramat Gan, HaMerkaz, Israel

Kaplan Medical Center

🇮🇱

Rehovot, HaMerkaz, Israel

Yitzhak Shamir Medical Center

🇮🇱

Zerifin, HaMerkaz, Israel

Shaare Zedek Medical Center

🇮🇱

Jerusalem, Yerushalayim, Israel

Hadassah Medical Center

🇮🇱

Jerusalem, Yerushalayim, Israel

University of Naples Federico II

🇮🇹

Napoli, Campania, Italy

Azienda Ospedaliero Universitaria S.Anna

🇮🇹

Cona, Emilia-Romagna, Italy

Istituto Scientifico Romagnolo per lo Studio e la Cura dei Tumori

🇮🇹

Meldola, Emilia-Romagna, Italy

Ospedale Fatebenefratelli-Oftalmico

🇮🇹

Milan, Milano, Italy

Humanitas

🇮🇹

Rozzano, Milano, Italy

Azienda Ospedaliera Sant'Andrea

🇮🇹

Rome, Roma, Italy

Azienda Ospedaliera Santa Maria

🇮🇹

Terni, TR, Italy

Ospedale Bellaria - Azienda USL di Bologna

🇮🇹

Bologna, Italy

Ospedale San Martino

🇮🇹

Genova, Italy

Azienda Ospedaliero Universitaria

🇮🇹

Modena, Italy

Istituto Nazionale Tumori IRCCS Fondazione Pascale

🇮🇹

Napoli, Italy

Azienda Ospedaliera Di Parma

🇮🇹

Parma, Italy

Aichi Cancer Center Hospital

🇯🇵

Nagoya, Aichi, Japan

Chiba Cancer Center

🇯🇵

Chiba-shi, Chiba, Japan

National Cancer Center Hospital East

🇯🇵

Kashiwa, Chiba, Japan

National Hospital Organization Shikoku Cancer Center

🇯🇵

Matsuyama, Ehime, Japan

Kurume General Hospital

🇯🇵

Kurume, Fukuoka, Japan

Gunma Prefectural Cancer Center

🇯🇵

Ōta, Gunma, Japan

Hiroshima University Hospital

🇯🇵

Hiroshima-shi, Hiroshima-ken, Japan

National Hospital Organization Hokkaido Cancer Center

🇯🇵

Sapporo, Hokkaido, Japan

University of tsukuba hospital

🇯🇵

Tsukuba-shi, Ibaragi, Japan

Tokai University Hospital- Isehara Campus

🇯🇵

Isehara, Kanagawa, Japan

Kanagawa Cancer Center

🇯🇵

Yokohama, Kanagawa, Japan

KKR Tohoku Kosai Hospital

🇯🇵

Aoba-ku, Sendai-shi, Miyagi, Japan

Niigata Cancer Center Hospital

🇯🇵

Niigata-shi, Niigata, Japan

Saitama Medical University International Medical Center

🇯🇵

Hidaka, Saitama, Japan

Jichi Medical University Hospital

🇯🇵

Shimotsuke, Tochigi, Japan

Tochigi Cancer Center

🇯🇵

Utsunomiya, Tochigi, Japan

Juntendo University Hospital

🇯🇵

Bunkyō-Ku, Tokyo, Japan

National Cancer Center Hospital

🇯🇵

Chuo Ku, Tokyo, Japan

St. Lukes International Hospital

🇯🇵

Chuo-Ku, Tokyo, Japan

Japanese Foundation for Cancer Research

🇯🇵

Koto, Tokyo, Japan

Showa University Hospital

🇯🇵

Shinagawa-ku, Tokyo, Japan

Tokyo Medical University Hospital

🇯🇵

Shinjuku-ku, Tokyo, Japan

National Center for Global Health and Medicine

🇯🇵

Shinjuku-ku, Tokyo, Japan

National Hospital Organization Kyushu Cancer Center

🇯🇵

Fukuoka, Japan

Sagara Hospital

🇯🇵

Kagoshima, Japan

Kumamoto University Hospital

🇯🇵

Kumamoto, Japan

Kumamoto Shinto General hospital

🇯🇵

Kumamoto, Japan

Kyoto University Hospital

🇯🇵

Kyoto, Japan

Osaka International Cancer Institute

🇯🇵

Osaka, Japan

Chungbuk National University Hospital

🇰🇷

Cheongju-si, Chungcheongbuk-do [Chungbuk], Korea, Republic of

Inha University Hospital

🇰🇷

Incheon, Incheon-gwangyeoksi [Incheon], Korea, Republic of

Gachon University Gil Medical Center

🇰🇷

Namdong-gu, Incheon-gwangyeoksi [Incheon], Korea, Republic of

National Cancer Center

🇸🇬

Singapore, Central Singapore, Singapore

Seoul National University Bundang Hospital

🇰🇷

Seongnam, Kyǒnggi-do, Korea, Republic of

Dongnam Institute of Radiological and Medical Sciences

🇰🇷

Busan, Pusan-Kwangyǒkshi, Korea, Republic of

Inje University Haeundae Paik Hospital

🇰🇷

Haeundae-gu, Pusan-Kwangyǒkshi, Korea, Republic of

Korea University Anam Hospital

🇰🇷

Seoul, Seoul-teukbyeolsi [Seoul], Korea, Republic of

Seoul National University Hospital

🇰🇷

Seoul, Seoul-teukbyeolsi [Seoul], Korea, Republic of

Severance Hospital Yonsei University Health System

🇰🇷

Seoul, Seoul-teukbyeolsi [Seoul], Korea, Republic of

Asan Medical Center

🇰🇷

Seoul, Seoul-teukbyeolsi [Seoul], Korea, Republic of

Samsung Medical Center

🇰🇷

Seoul, Seoul-teukbyeolsi [Seoul], Korea, Republic of

Korea University Guro Hospital

🇰🇷

Seoul, Seoul-teukbyeolsi [Seoul], Korea, Republic of

Ewha Womans University Mokdong Hospital

🇰🇷

Seoul, Seoul-teukbyeolsi [Seoul], Korea, Republic of

CIMAB S.A. de C.V.

🇲🇽

Torreon, Coahuila, Mexico

Grupo Medico Camino S.C.

🇲🇽

México City, Distrito Federal, Mexico

Health Pharma Professional Research, S.A. de C.V.

🇲🇽

Ciudad de México, Federal District, Mexico

Centro Oncológico Internacional (COI)

🇲🇽

Guadalajara, Jalisco, Mexico

Filios Alta Medicina

🇲🇽

Monterrey, Nuevo Leon, Mexico

Neurociencias Estudios Clinicos S.C.

🇲🇽

Culiacan, Sinaloa, Mexico

Medical Care and Research, S.A. de C.V.

🇲🇽

Merida, Yucatan, Mexico

Centro de Atención e Investigación Clínica en Oncología

🇲🇽

Merida, Yucatan, Mexico

Oaxaca Site Management Organization SC

🇲🇽

Oaxaca, Mexico

Unidad Médica Onco-hematológica

🇲🇽

Puebla, Mexico

Oncológico Potosino

🇲🇽

San Luis Potosí, Mexico

Maastricht UMC+

🇳🇱

Maastricht, Limburg, Netherlands

Onze Lieve Vrouwe Gasthuis (OLVG)

🇳🇱

Amsterdam, Noord-Holland, Netherlands

Waikato Hospital

🇳🇿

Hamilton, Waikato, New Zealand

Palmerston North Hospital

🇳🇿

Palmerston North, Wanganui, New Zealand

Auckland City Hospital

🇳🇿

Auckland, New Zealand

Dolnośląskie Centrum Onkologii we Wrocławiu

🇵🇱

Wroclaw, Dolnośląskie, Poland

Luxmed Onkologia sp. z o. o.

🇵🇱

Warszawa, Mazowieckie, Poland

Uniwersyteckie Centrum Kliniczne

🇵🇱

Gdansk, Pomorskie, Poland

Szpitale Pomorskie Sp. z o. o.

🇵🇱

Gdynia, Pomorskie, Poland

Przychodnia Lekarska "Komed"

🇵🇱

Konin, Wielkopolskie, Poland

Centro Hospitalar do Porto - Hospital de Santo António

🇵🇹

Porto, Portugal

IPOFG - Porto

🇵🇹

Porto, Portugal

Puerto Rico Hematology/Oncology Group

🇵🇷

Bayamon, Puerto Rico

UPR Comprehensive Cancer Center

🇵🇷

San Juan, Puerto Rico

Ovidius Clinical Hospital OCH

🇷🇴

Ovidiu, Constanta, Romania

Spitalul Clinic Filantropia

🇷🇴

Bucuresti, Romania

Chelyabinsk Regional Oncology Dispensary

🇷🇺

Chelyabinsk, Chelyabinskaya Oblast', Russian Federation

Kaluga Regional Clinical Oncology Center

🇷🇺

Kaluga, Kalužskaja Oblast', Russian Federation

Kursk Regional Oncology Dispensary

🇷🇺

Kursk, Kurskaya Oblast', Russian Federation

Fed State Budgetary Inst "N.N. Blokhin Med Center of Oncology" MHRF

🇷🇺

Moscow, Moskva, Russian Federation

Burdenko Main Military Hospital

🇷🇺

Moscow, Moskva, Russian Federation

Orenburg Regional Clinical Oncology Dispensary

🇷🇺

Orenburg, Orenburgskaya Oblast', Russian Federation

Leningrad Regional Oncology Dispensary

🇷🇺

Saint Petersburg, Sankt-Peterburg, Russian Federation

North-Western State Medical University named after I.I.Mechnikov

🇷🇺

St. Petersburg, Sankt-Peterburg, Russian Federation

N.N.Petrov Research Institute of Oncology

🇷🇺

St. Petersburg, Sankt-Peterburg, Russian Federation

Republican Clinical Oncology Dispensary

🇷🇺

Kazan, Tatarstan Republic, Russian Federation

Blokhin Cancer Research Center

🇷🇺

Moscow, Russian Federation

King Abdulaziz Medical City - National Guard Hospital

🇸🇦

Riyadh, Ar Riyāḑ, Saudi Arabia

King Fahad Medical City

🇸🇦

Riyadh, Ar Riyāḑ, Saudi Arabia

King Fahad Specialist Hospital-Dammam

🇸🇦

Dammam, Ash Sharqīyah, Saudi Arabia

King Faisal Specialist Hospital & Research Center

🇸🇦

Riyadh, Saudi Arabia

National University Hospital

🇸🇬

Singapore, Singapore

Cancercare Langenhoven Drive Oncology Centre

🇿🇦

Port Elizabeth, Eastern Cape, South Africa

Life Groenkloof

🇿🇦

Pretoria, Gauteng, South Africa

Eastleigh Breast Care Center

🇿🇦

Pretoria, Gauteng, South Africa

Sandton Oncology Medical Group (Pty) Ltd

🇿🇦

Sandton, Gauteng, South Africa

Cancercare Rondebosch Oncology

🇿🇦

Cape Town, Western Cape, South Africa

GVI Oncology

🇿🇦

George, Western Cape, South Africa

Hospital Universitario Reina Sofia

🇪🇸

Cordoba, Andalucía, Spain

Hospital Universitario Central de Asturias

🇪🇸

Oviedo, Asturias, Spain

Hospital Quiron Barcelona

🇪🇸

Barcelona, Barcelona [Barcelona], Spain

Hospital Clínic de Barcelona

🇪🇸

Barcelona, Catalunya [Cataluña], Spain

Hospital de la Santa Creu i Sant Pau

🇪🇸

Barcelona, Catalunya [Cataluña], Spain

CHUS - Hospital Clinico Universitario

🇪🇸

Santiago de Compostela, La Coruna, Spain

Hospital Universitario Fundacion ALcorcon

🇪🇸

Alcorcón, Madrid, Comunidad De, Spain

Hospital Universitario Ramón y Cajal

🇪🇸

Madrid, Madrid, Comunidad De, Spain

Hospital Universitario 12 de Octubre

🇪🇸

Madrid, Madrid, Comunidad De, Spain

Hospital Universitario Quironsalud Madrid

🇪🇸

Pozuelo de Alarcon, Madrid, Spain

Hospital Universitario Virgen de la Victoria

🇪🇸

Malaga, Málaga, Spain

Hospital Universitario de Canarias

🇪🇸

San Cristobal de La laguna, Santa Cruz De Tenerife, Spain

Parc de Salut Mar - Hospital del Mar

🇪🇸

Barcelona, Spain

Hospital Universitari Vall d'Hebron

🇪🇸

Barcelona, Spain

Hospital La Princesa

🇪🇸

Madrid, Spain

Hospital General Universitario Gregorio Marañon

🇪🇸

Madrid, Spain

Hospital Clinico San Carlos

🇪🇸

Madrid, Spain

Hospital Universitario HM Sanchinarro

🇪🇸

Madrid, Spain

Hospital Universitario Virgen Macarena

🇪🇸

Sevilla, Spain

Hospital Universitario Virgen del Rocio

🇪🇸

Sevilla, Spain

Hospital Universitario Virgen de Valme

🇪🇸

Sevilla, Spain

Hospital Quirón Salud Valencia

🇪🇸

Valencia, Spain

Hospital Universitario Miguel Servet

🇪🇸

Zaragoza, Spain

Skånes universitetssjukhus Lund

🇸🇪

Malmö, Skåne Län [se-12], Sweden

Norrlands universitetssjukhus

🇸🇪

Umeå, Västerbottens Län [se-24], Sweden

Sundsvalls Sjukhus

🇸🇪

Sundsvall, Västernorrlands Län [se-22], Sweden

Västmanlands sjukhus Västerås

🇸🇪

Västerås, Västmanlands Län [se-19], Sweden

Växjö Centrallasarettet

🇸🇪

Växjö, Sweden

Chang Gung Memorial Hospital - Kaohsiung

🇨🇳

Kaohsiung Niao Sung Dist, Kaohsiung, Taiwan

Tri-Service General Hospital

🇨🇳

Taipei City, Taipei, Taiwan

Changhua Christian Hospital

🇨🇳

Changhua, Taiwan

Kaohsiung Medical University Chung-Ho Memorial Hospital

🇨🇳

Kaohsiung City, Taiwan

Taipei Medical University Hospital

🇨🇳

New Taipei City, Taiwan

China Medical University Hospital

🇨🇳

Taichung, Taiwan

MacKay Memorial Hospital

🇨🇳

Taipei City, Taiwan

National Taiwan University Hospital

🇨🇳

Taipei, Taiwan

Taipei Veterans General Hospital

🇨🇳

Taipei, Taiwan

Koo Foundation Sun Yat-Sen Cancer Center

🇨🇳

Taipei, Taiwan

Chang Gung Medical Foundation-Linkou Branch

🇨🇳

Taoyuan City, Taiwan

Istanbul Universitesi Cerrahpasa

🇹🇷

Istanbul- Fatih, İstanbul, Turkey

Acibadem Altunizade Hospital

🇹🇷

Üsküdar/stanbul, İstanbul, Turkey

Izmir Medical Park Hospital

🇹🇷

Izmir, Karsiyaka, Izmir, Turkey

Baskent University Dr. Turgut Noyan Research and Training Center

🇹🇷

Adana, Turkey

Ankara Universitesi Tip Fakultesi Hastanesi

🇹🇷

Ankara, Turkey

Hacettepe Universitesi

🇹🇷

Ankara, Turkey

Akdeniz Universitesi Hastanesi

🇹🇷

Antalya, Turkey

Trakya University Faculty of Medicine

🇹🇷

Edirne, Turkey

TC Saglik Bakanligi Goztepe Prof. Dr. Suleyman Yalcin Sehir Hastanesi

🇹🇷

Istanbul, Turkey

Kocaeli Üniversitesi

🇹🇷

Kocaeli, Turkey

Municipal Non-profit Enterprise "City Clinical Hospital #4" of Dnipro City Council

🇺🇦

Dnipro, Dnipropetrovska Oblast, Ukraine

Communal Enterprise 'Kryvyi Rih Oncology Dispensary' of the Dnipropetrovsk Regional Council

🇺🇦

Kryvyi Rih, Dnipropetrovska Oblast, Ukraine

Municipal non-profit enterprise'Odesa Regional Clinical Hospital'of Odesa Regional Council

🇺🇦

Odesa, Odeska Oblast, Ukraine

Poltava Regional Clinical Oncology Center

🇺🇦

Poltava, Poltavska Oblast, Ukraine

Communal Noncommercial Enterprise "Podillia Regional Oncology Center Of Vinnytsia Regional Council"

🇺🇦

Vinnytsia, Vinnytska Oblast, Ukraine

Municipal Enterprise "Volyn Regional Medical Oncology Centre" of the Volyn Regional Council

🇺🇦

Lutsk, Volynska Oblast, Ukraine

Uzhgorod Central City Clinical Hospital

🇺🇦

Uzhhorod, Zakarpatska Oblast, Ukraine

Mid Essex Hospital Services NHS Trust

🇬🇧

Chelmsford, Essex, United Kingdom

North Middlesex Hospital

🇬🇧

London, Greater London, United Kingdom

Charing Cross Hospital

🇬🇧

London, Hammersmith And Fulham, United Kingdom

Mount Vernon Hospital

🇬🇧

Northwood, Hertfordshire, United Kingdom

Victoria Hospital

🇬🇧

Blackpool, Lancashire, United Kingdom

Royal Preston Hospital

🇬🇧

Preston, Lancashire, United Kingdom

Boston Pilgrim Hospital

🇬🇧

Boston, Lincolnshire, United Kingdom

Sarah Canon Research Institute UK

🇬🇧

London, London, City Of, United Kingdom

James Cook University Hospital

🇬🇧

Central Middlesbrough, Middlesbrough, United Kingdom

Western General Hospital

🇬🇧

Edinburgh, Midlothian, United Kingdom

Nottingham City Hospital

🇬🇧

Nottingham, Nottinghamshire, United Kingdom

The Churchill Hospital

🇬🇧

Oxford, Oxfordshire, United Kingdom

Musgrove Park Hospital

🇬🇧

Taunton, Somerset, United Kingdom

Royal Surrey County Hospital

🇬🇧

Guildford, Surrey, United Kingdom

Royal Marsden Hospital

🇬🇧

London, Sutton, United Kingdom

Airedale General Hospital

🇬🇧

Bradford, United Kingdom

The Christie

🇬🇧

Manchester, United Kingdom

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