Evaluation of Titanium Platelet Rich Fibrin and Advanced Platelet Rich Fibrin in Treatment of Periodontal Intrabony Defects: A Cone Beam Computed Tomography Analysis

Periodontitis is a multifactorial disease characterized by the irreversible loss of connective tissue attachment and supporting alveolar bone. The ultimate goal pertaining to periodontal therapy is to control the active inflammation and the reconstruction of the structure lost due to periodontal disease. PRF stimulates the vascular system and promotes angiogenesis, releases growth factors such as vascular endothelial growth factor (VEGF), platelet derived growth factor (PDGF), insulin-like growth factor (IGF), and transforming growth factor (TGF) that are involved in tissue regeneration. Although PRF has shown promising clinical results, some experts are worried about potential health risks because it uses glass evacuated collection tubes for blood with silica activators. Tunali M. et al. created a novel platelet concentrate in 2013 called titanium-prepared, platelet-rich fibrin (T-PRF). The preparation technique is predicated on the idea that titanium tubes, as opposed to the glass tubes utilized in Choukroun’s method, could be more successful at activating platelets. In 2014, Ghanaati et al. introduced a new modification called Advanced-PRF (A-PRF), which matrices in their solid form, utilizes a low-speed centrifugation protocol. This method offers the additional advantage of evenly distributed cells, promoting effective regeneration. Hence, this study is designed to compare and evaluate the effectiveness of T-PRF and A-PRP clinically and radiographically (using cone beam computed tomography) in the management of periodontal intrabony defects.