Comparison and assessment of two materials derived from patients own blood in treating bone defects around gums and teeth
- Conditions
- Chronic periodontitis,
- Registration Number
- CTRI/2025/05/087724
- Lead Sponsor
- Institute of dental sciences Bareilly
- Brief Summary
Periodontitis is a multifactorial disease characterized by the irreversible loss of connective tissue attachment and supporting alveolar bone. The ultimate goal pertaining to periodontal therapy is to control the active inflammation and the reconstruction of the structure lost due to periodontal disease. PRF stimulates the vascular system and promotes angiogenesis, releases growth factors such as vascular endothelial growth factor (VEGF), platelet derived growth factor (PDGF), insulin-like growth factor (IGF), and transforming growth factor (TGF) that are involved in tissue regeneration. Although PRF has shown promising clinical results, some experts are worried about potential health risks because it uses glass evacuated collection tubes for blood with silica activators. Tunali M. *et al.* created a novel platelet concentrate in 2013 called titanium-prepared, platelet-rich fibrin (T-PRF). The preparation technique is predicated on the idea that titanium tubes, as opposed to the glass tubes utilized in Choukroun’s method, could be more successful at activating platelets. In 2014, Ghanaati *et al.* introduced a new modification called Advanced-PRF (A-PRF), which matrices in their solid form, utilizes a low-speed centrifugation protocol. This method offers the additional advantage of evenly distributed cells, promoting effective regeneration. Hence, this study is designed to compare and evaluate the effectiveness of T-PRF and A-PRP clinically and radiographically (using cone beam computed tomography) in the management of periodontal intrabony defects.
- Detailed Description
Not available
Recruitment & Eligibility
- Status
- Not Yet Recruiting
- Sex
- All
- Target Recruitment
- 42
Individuals diagnosed with stage II or stage III periodontitis (AAP Classification of periodontitis 2017) Age group of 20 to 55 years Probing pocket depth more than equal to 5mm Clinical attachment loss more than equal to 3mm Radiographic evidence of intrabony defect.
Systemically compromised patients Patients who are on medications that may impede wound healing Patients who are smokers Pregnant and lactating females.
Study & Design
- Study Type
- Interventional
- Study Design
- Not specified
- Primary Outcome Measures
Name Time Method Mean gain in bone volume baseline and 6 months
- Secondary Outcome Measures
Name Time Method pocket probing depth reduction relative attachment level gain
Trial Locations
- Locations (1)
Institute Of Dental Sciences Bareilly
🇮🇳Bareilly, UTTAR PRADESH, India
Institute Of Dental Sciences Bareilly🇮🇳Bareilly, UTTAR PRADESH, IndiaIram khanPrincipal investigator07500410078iramkhanbds2020@gmail.com