A Prospective Trial of Behavioral Therapy for Chronic Cough
Overview
- Phase
- Not Applicable
- Intervention
- Not specified
- Conditions
- Cough
- Sponsor
- University of California, San Diego
- Enrollment
- 45
- Locations
- 1
- Primary Endpoint
- Percentage of Cough reduction
- Last Updated
- 5 years ago
Overview
Brief Summary
This study seeks to explore whether heart rate variability (HRV) biofeedback can be effective in the treatment of chronic cough. Chronic cough has many causes, including asthma, postnasal drip, and gastroesophageal reflux disease (GERD), each with a specific treatment. However, among a subset of cough patients, no clear cause is found despite extensive workup, and traditional treatment methods do not provide relief. Several studies revealed less common causes of chronic cough and disordered breathing such as vagal neuropathy, paradoxical vocal fold motion, and stress. Additional research identified links between the neurological networks that produce the cough reflex and those that maintain normal breathing. HRV biofeedback is a self-regulation technique that uses computer equipment to monitor heart rate and breathing, two key functions of the autonomic nervous system. By using this non-invasive behavioral technique, cough patients can regulate their breathing and autonomic function, potentially leading to improved autonomic balance and a reduction in cough symptoms.
Investigators
Philip Weissbrod
Director, Center for Voice and Swallowing
University of California, San Diego
Eligibility Criteria
Inclusion Criteria
- •8+ weeks of cough, Fluent English speaker, Have access to an electronic mobile device
Exclusion Criteria
- •On neuromodulator therapy, cardiac arrhythmia, dysphagia, prior HRVB or mindfulness, head and neck surgery of the oropharynx, neck or larynx, lung surgery, pulmonary pathology other than asthma, tourette syndrome, ACE inhibitor use, current or recent smoker.
- •Added exclusion criteria as of March 2020 - history of COVID+.
Outcomes
Primary Outcomes
Percentage of Cough reduction
Time Frame: 3 weeks
Measured by changes in cough severity index and patient recordings
Secondary Outcomes
- Durability of cough remediation(8 weeks)
- Changes in dyspnea(3 weeks)
- Change in voice(3 weeks)