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临床试验/NCT07467941
NCT07467941尚未招募不适用

Impact of Visceral Adiposity on Postoperative Atrial Fibrillation After Coronary Artery Bypass Grafting (CABG): A Prospective Observational Study

Kartal Kosuyolu Yuksek Ihtisas Education and Research Hospital0 个研究点目标入组 300 人开始时间: 2026年4月1日最近更新:
干预措施

试验速览

阶段
不适用
状态
尚未招募
发起方
入组人数
300
主要终点
Effect of visceral adipose tissue thickness on postoperative atrial fibrillation

研究概览

简要总结

Obesity has become a major public health problem in both developed and developing countries, with a continuous increase particularly since the 1980s. Moreover, it is a well-established metabolic risk factor for diabetes mellitus, hypertension, and various types of cancer, as well as cardiovascular diseases such as heart failure and coronary artery disease. Body mass index (BMI) is calculated by dividing body weight in kilograms by the square of height in meters and is widely used as an indicator of obesity. However, BMI does not quantitatively reflect body fat distribution and fails to account for components such as skeletal muscle and bone mass. Therefore, interest in assessing body fat distribution has increased, and in recent years, studies evaluating the correlation between anthropometric, biochemical, and anatomical measurements and clinical outcomes have become more frequent. In particular, it is acknowledged that abdominal obesity cannot be accurately represented by BMI alone and is primarily associated with visceral adipose tissue (VAT). The aim of this study is to evaluate the association between preoperative visceral and subcutaneous adipose tissue measurements (VAT and SAT), assessed by ultrasonography in patients scheduled for open-heart surgery, and the development of postoperative atrial fibrillation.

研究设计

研究类型
Observational
观察模型
Other
时间视角
Prospective

入排标准

年龄范围
18 Years 至 —(Adult, Older Adult)
性别
All
接受健康志愿者

入选标准

  • Elective isolated coronary artery bypass graft surgery (on-pump)
  • Age ≥18 years, planned prospectively in 300 patients

排除标准

  • Patients requiring urgent or emergency surgery
  • Off-pump coronary artery bypass graft surgery
  • Surgeries other than isolated coronary artery bypass graft
  • Patients in whom abdominal ultrasound measurement cannot be performed (e.g., due to severe deformity, wounds, edema)
  • Active malignancy
  • eGFR <30 mL/min
  • Advanced-stage chronic obstructive pulmonary disease (COPD)
  • Preoperative atrial fibrillation or atrial flutter
  • Patients who do not provide written informed consent for the study

研究组 & 干预措施

Group 1: Postoperative AF Group

Visceral and subcutaneous adipose tissue thickness in patients who develop postoperative atrial fibrillation after coronary artery bypass graft surgery.

干预措施: Postoperative AF Group (Other)

Group 2: Non-AF Group

Visceral and subcutaneous adipose tissue thickness in patients who do not develop postoperative atrial fibrillation after coronary artery bypass graft surgery.

干预措施: Non-AF Group (Other)

结局指标

主要结局

Effect of visceral adipose tissue thickness on postoperative atrial fibrillation

时间窗: Within 7 days after coronary artery bypass graft surgery or until hospital discharge

Preoperative ultrasound-guided measurement of visceral adipose tissue thickness will be performed. The association between visceral fat thickness and the development of postoperative atrial fibrillation will be evaluated.

次要结局

未报告次要终点

研究者

发起方
Kartal Kosuyolu Yuksek Ihtisas Education and Research Hospital
申办方类型
Other Gov
责任方
Principal Investigator
主要研究者

ÖZGE PEKŞEN KIZILIŞIK

Anesthesiology and Reanimation Specialist, M.D.

Kartal Kosuyolu Yuksek Ihtisas Education and Research Hospital

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