A Study on the Immune Response and Safety of Vaccine Against Respiratory Syncytial Virus (RSV) Given to Adults 18 to 49 Years of Age at Increased Risk for Respiratory Syncytial Virus Disease, Compared to Older Adults 60 Years of Age and Above
- Conditions
- Respiratory Syncytial Virus Infections
- Interventions
- Registration Number
- NCT06389487
- Lead Sponsor
- GlaxoSmithKline
- Brief Summary
The aim of this study is to demonstrate the immune response and to evaluate safety of the RSVPreF3 OA investigational vaccine in non-immunocompromised adults 18-49 years of age (YOA), who are at increased risk (AIR) for respiratory syncytial virus (RSV) disease, compared to older adults (OA) (\>=) 60 YOA and above
- Detailed Description
Not available
Recruitment & Eligibility
- Status
- COMPLETED
- Sex
- All
- Target Recruitment
- 1459
- Participants and/or participant's parent(s)/ Legally acceptable representative (LAR) who, in the opinion of the investigator, can and will comply with the requirements of the protocol (e.g., completion of the eDiary, attend study site visits, ability to access and utilize a phone or other electronic communications).
- Written or witnessed informed consent obtained from the participant/participant's parent(s)/LAR(s) (participant must be able to understand the informed consent) prior to performance of any study-specific procedure.
Written informed assent obtained from the participant (participant must be able to understand the informed assent) if he/she is less than the legal age prior to performance of any study-specific procedure.
Specific inclusion criteria for all participants in Cohort 1 and Cohort 3 (RSV-A-AIR Group) • A male or female participant 18-49 YOA at the time of the study intervention administration.
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Participants should be diagnosed with at least 1 of the following medical conditions if considered medically stable by the investigator:
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Chronic cardiopulmonary disease resulting in activity restricting symptoms or use of long term medication:
o Chronic obstructive pulmonary disease (COPD)
o Asthma
o Cystic fibrosis
o Other chronic respiratory diseases: lung fibrosis, restrictive lung disease, interstitial lung disease, emphysema or bronchiectasis
o Chronic heart failure:
o Pre-existing Coronary Artery Disease (CAD) (CAD not otherwise specified)
- Cardiac arrhythmia
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Diabetes mellitus: types 1 or 2 with active treatment for the past 6 months
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Other diseases at increased risk for RSV disease:
- Chronic kidney disease
- Chronic moderate to severe liver disease
- Neurologic or neuromuscular conditions
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Female participants of non-childbearing potential may be enrolled in the study. Non-childbearing potential is defined as premenarche, hysterectomy, bilateral oophorectomy, bilateral salpingectomy or post-menopause.
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Female participants of childbearing potential may be enrolled in the study, if the participant:
- has practiced adequate contraception from 1 month prior to study intervention administration, and
- has a negative pregnancy test on the day of study prior to intervention administration, and
- has agreed to continue adequate contraception for at least 1 month after completion of the study intervention administration.
Specific inclusion criteria for all participants in Cohort 2 (RSV-OA Group):
• A male or female participant >=60 YOA at the time of the study intervention administration.
Participants with chronic stable medical conditions with or without specific treatment, such as diabetes, hypertension or cardiac disease are allowed to participate in this study if considered medically stable by the investigator.
• Participants living in the general community or in an assisted-living facility that provides minimal assistance, such that the participant is primarily responsible for self-care and activities of daily living.
Medical conditions
- Any confirmed or suspected immunosuppressive or immunodeficient condition resulting from disease (e.g., current malignancy, human immunodeficiency virus) or immunosuppressive/cytotoxic therapy (e.g., medication used during cancer chemotherapy, organ transplantation, or to treat autoimmune disorders), based on medical history and physical examination (no laboratory testing required).
- History of any reaction or hypersensitivity likely to be exacerbated by any component of the study intervention.
- Unstable chronic illness.
- Any history of dementia or any medical condition that moderately or severely impairs cognition.
- Recurrent or uncontrolled neurological disorders or seizures. Participants with medically controlled active or chronic neurological diseases can be enrolled in the study as per investigator assessment, provided that their condition will allow them to comply with the requirements of the protocol (e.g., completion of the diary cards, attend study site visits). Study participants may decide to assign a caregiver to help them complete the study procedures.
- Significant underlying illness that in the opinion of the investigator would be expected to prevent completion of the study (e.g., life-threatening disease).
- Any medical condition that in the judgment of the investigator would make intramuscular injection unsafe.
- Any other clinical condition that, in the opinion of the investigator, might pose additional risk to the participant due to participation in the study.
Prior/Concomitant therapy
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Use of any investigational or non-registered product (drug, vaccine, or medical device) other than the study intervention during the period beginning 30 days before the dose of study intervention (Day -29 to Day 1), or planned use during the study period (up to Visit 3, Month 6).
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Planned or actual administration of a vaccine not foreseen by the study protocol in the period starting 30 days before and ending 30 days after the dose of study intervention administration, with the exception of inactivated, subunit and split influenza vaccines or COVID-19 vaccines which can be administered up to 14 days before or from 14 days after the study intervention administration.
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Previous vaccination with any RSV vaccine, including investigational RSV vaccines.
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Chronic administration of immune-modifying drugs (defined as more than 14 consecutive days in total) and/or administration of long-acting immune-modifying treatments or planned administration at any time up to the End-of-study (EOS).
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Up to 3 months prior to the study intervention administration:
- For corticosteroids, this will mean prednisone >=20 mg/day, or equivalent. Inhaled, topical and intra-articular steroids are allowed
- Administration of immunoglobulins and/or any blood products or plasma derivatives
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Up to 6 months prior to study intervention administration: long-acting immune-modifying drugs including among others immunotherapy (e.g., Tumor Necrosis Factor (TNF)-inhibitors), monoclonal antibodies, antitumoral medication.
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Prior/Concurrent clinical study experience
• Concurrently participating in another clinical study, at any time during the study period, in which the participant has been or will be exposed to an investigational or a non-investigational vaccine/product (drug or invasive medical device).
Other exclusions:
Other exclusions for all participants:
- History of chronic alcohol consumption and/or drug abuse as deemed by the investigator to render the potential participant unable/unlikely to provide accurate safety reports or comply with study procedures.
- Bedridden participants.
- Planned move during the study period that will prohibit participating in the study until study end.
- Participation of any study personnel or their immediate dependents, family, or household members.
Other exclusions for Cohort 1 and Cohort 3:
- Pregnant or lactating female participant.
- Female planning to become pregnant or planning to discontinue contraceptive precautions within 1 month after study intervention administration.
Study & Design
- Study Type
- INTERVENTIONAL
- Study Design
- PARALLEL
- Arm && Interventions
Group Intervention Description Part A: RSV-A-AIR Group RSVPreF3 OA investigational vaccine Adult participants, 18-49 YOA, at increased risk (AIR) for RSV disease, receive a single dose of RSVPreF3 OA investigational vaccine at Day 1 and are followed up until end of study (6 months post vaccine dose administration). Part A: RSV-OA Group RSVPreF3 OA investigational vaccine Older adults (OA) participants, \>=60 YOA, receive a single dose of RSVPreF3 OA investigational vaccine at Day 1 and are followed up until end of study (6 months post vaccine dose administration). Part B: RSV-A-AIR Group RSVPreF3 OA investigational vaccine Adult participants, 18-49 YOA, at increased risk (AIR) for RSV disease, receive a single dose of RSVPreF3 OA investigational vaccine at Day 1 and are followed up until end of study (6 months post vaccine dose administration).
- Primary Outcome Measures
Name Time Method Part A: RSV-A neutralizing titers expressed as group Geometric Mean Titers (GMTs) (RSV-OA over RSV-A-AIR) At 1 month (Day 31) post-RSVPreF3 OA investigational vaccine dose administration RSV-A neutralizing titers are given as group GMTs and are expressed as Estimated Dilution 60 (ED60).
Part A: Seroresponse rate (SRR) in RSV-A neutralizing titers At 1 month (Day 31) post-RSVPreF3 OA investigational vaccine dose administration compared to baseline (Day 1) SRR is defined as the proportion of participants having a fold increase in neutralizing titers (1 month post-study intervention administration over pre-study intervention administration) greater than or equal to (≥) 4. RSV-A neutralizing titers are expressed as Estimated Dilution 60 (ED60).
Part A: RSV-B neutralizing titers expressed as GMT ratio (RSV-OA over RSV-A-AIR) At 1 month (Day 31) post-RSVPreF3 OA investigational vaccine dose administration RSV-B neutralizing titers are given as group GMTs and are expressed as Estimated Dilution 60 (ED60).
Part A: SRR in RSV-B neutralizing titers At 1 month (Day 31) post-RSVPreF3 OA investigational vaccine dose administration compared to baseline (Day 1) SRR is defined as the proportion of participants having a fold increase in neutralizing titers (1-month post-study intervention administration over pre-study intervention administration) ≥ 4. RSV-B neutralizing titers are expressed as Estimated Dilution 60 (ED60).
- Secondary Outcome Measures
Name Time Method Part A and B: Percentage of participants reporting unsolicited adverse events (AEs) During the 30-day follow up period after vaccination (vaccine administered at Day 1) An unsolicited AE is an AE that was either not included in the list of solicited events or could be included in the list of solicited events but with an onset outside the specified period of follow-up for solicited events. Unsolicited AEs include both serious and nonserious AEs.
Part A and B: Percentage of participants reporting any serious adverse events (SAEs), related SAEs and fatal SAEs From study intervention administration (Day 1) up to study end (Month 6 after study intervention administration) An SAE is any untoward medical occurrence that results in death, is life-threatening, requires hospitalization or prolongation of existing hospitalization, results in disability/incapacity, is a congenital anomaly/birth defect in the offspring of a study participant, is considered or defined as an important medical event, or abnormal pregnancy outcomes. Any SAE = occurrence of the SAE regardless of relation to study vaccination. Related SAE = SAE assessed by the investigator as related to the study vaccination. Fatal SAE = occurrence of a fatal SAE regardless of relation to study vaccination.
Part A and B: Percentage of participants reporting solicited administration site events During the 4-day follow up period after vaccination (vaccine administered at Day 1) The assessed solicited administration site events are pain, redness and swelling at administration site.
Part A and B: Percentage of participants reporting any adverse events of special interest (AESIs), including potential immune-mediated diseases (pIMDs) and atrial fibrillation (AF) From study intervention administration (Day 1) up to study end (Month 6 after study intervention administration) pIMDs are a subset of AESIs that include autoimmune diseases and other inflammatory and/or neurologic disorders of interest which may or may not have an autoimmune etiology. AEs of AF are considered as AESI.
Part A: RSV-A neutralizing titers expressed as GMTs At pre-study intervention administration (Day 1), at Month 1 and Month 6 post-study intervention administration RSV-A neutralizing titers are given as GMTs and are expressed as Estimated Dilution 60 (ED60).
Part A: RSV-B neutralizing titers expressed as GMTs At pre-study intervention administration (Day 1), at Month 1 and Month 6 post-study intervention administration RSV-B neutralizing titers are given as GMTs and are expressed as Estimated Dilution 60 (ED60).
Part A and B: Percentage of participants reporting solicited systemic events During the 4-day follow up period after vaccination (vaccine administered at Day 1) The assessed solicited systemic events are fever, headache, myalgia (muscle pain), arthralgia (joint pain) and fatigue (tiredness). Fever is defined as temperature \>= 38.0 degrees Celsius (°C) /100.4 degrees Fahrenheit (°F), regardless of the location of . measurement. The route for measuring temperature can be oral or axillary.
Trial Locations
- Locations (1)
GSK Investigational Site
🇿🇦Reiger Park, South Africa