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Serum Biomarkers Analysis in Patients With AR Treated With Anti-TMF

Conditions
Rheumatoid Arthritis
Interventions
Drug: Anti-TNF
Registration Number
NCT02804204
Lead Sponsor
Hospital Universitari Vall d'Hebron Research Institute
Brief Summary

Multicenter, prospective, observational study for evaluating if circulant rheumatoid factor, cyclic citrullinated anti-peptide anti-bodies and albumin can be used as potential predictors in the response to the treatment with anti-TNF in patients with rheumatoid arthritis after 24 weeks of treatment.

Detailed Description

Not available

Recruitment & Eligibility

Status
UNKNOWN
Sex
All
Target Recruitment
200
Inclusion Criteria
  • Both genders
  • Over 18 years old
  • Diagnosis of rheumatoid arthritis according to ACR criteria
  • Patients that initiate treatment with anti-TNF drugs according to clinical practice, both in naïve anti-TNF patients and patients after first anti-TNF failure
  • Patients able to follow the protocol requirements
  • Patients that signed the informed consent
Exclusion Criteria
  • Patients with known hypersensitivity to investigational products
  • Patients with tuberculosis, or severe infections like sepsis or opportunistic infections
  • Patients with moderate/severe cardiac insufficiency (NHYA classification Class III/IV)
  • Patients that according to the investigator criteria can not participate in the study or complete the study questionnaires
  • Pregnant or fertile woman that does not use a contraception method

Study & Design

Study Type
OBSERVATIONAL
Study Design
Not specified
Arm && Interventions
GroupInterventionDescription
Anti-TNFAnti-TNF-
Primary Outcome Measures
NameTimeMethod
Anti-TNF treatment response based on circulant cyclic citrullinated anti-peptide antibodies.24 weeks
Anti-TNF treatment response based on circulant rheumatoid factor24 weeks
Secondary Outcome Measures
NameTimeMethod

Trial Locations

Locations (19)

Hospital Virgen del Rocio

🇪🇸

Sevilla, Andalucia, Spain

Clínic de Barcelona

🇪🇸

Barcelona, Catalunya, Spain

Hospital de Basurto

🇪🇸

Bilbao, Pais Vasco, Spain

Hospital Clínico San Carlos

🇪🇸

Madrid, Comunidad De Madrid, Spain

Hospital Puerta de Hierro

🇪🇸

Madrid, Comunidad De Madrid, Spain

Hospital La Paz

🇪🇸

Madrid, Comunidad De Madrid, Spain

Hospital Marques de Valdecilla

🇪🇸

Santander, Cantabria, Spain

Hospital Universitario de Canarias

🇪🇸

La Laguna, Canarias, Spain

Hospital Vall d'Hebron

🇪🇸

Barcelona, Catalunya, Spain

Hospital Virgen de la Arreixaca

🇪🇸

Murcia, Región De Murcia, Spain

Hospital de Santa Creu i Sant Pau

🇪🇸

Barcelona, Catalunya, Spain

Hospital Carlos Haya

🇪🇸

Málaga, Andalucia, Spain

Hospital San Cecilio

🇪🇸

Granada, Andalucia, Spain

Hospital de Guadalajara

🇪🇸

Guadalajara, Castilla-La Mancha, Spain

Hospital Son LLatzer

🇪🇸

Palma de Mallorca, Baleares, Spain

Hospital Moises Broggi

🇪🇸

Sant Joan Despí, Catalunya, Spain

Hospital de Bellvitge

🇪🇸

L'Hospitalet de Llobregat, Catalunya, Spain

Hospital Infanta Sofía

🇪🇸

Madrid, Comunidad De Madrid, Spain

Complexo Hospitalaria A Coruña

🇪🇸

A Coruña, Galicia, Spain

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