NCT02804204Unknown不适用
Analysis of Circulant Rheumatoid Factor, Cyclic Citrullinated Anti-peptide Anti-bodies and Albumin as a Potential Predictor in the Response to the Treatment With Anti-TNF in Patients With Rheumatoid Arthritis
适应症
干预措施
相关药物
试验速览
- 阶段
- 不适用
- 入组人数
- 200
- 试验地点
- 19
- 主要终点
- Anti-TNF treatment response based on circulant cyclic citrullinated anti-peptide antibodies.
研究概览
简要总结
Multicenter, prospective, observational study for evaluating if circulant rheumatoid factor, cyclic citrullinated anti-peptide anti-bodies and albumin can be used as potential predictors in the response to the treatment with anti-TNF in patients with rheumatoid arthritis after 24 weeks of treatment.
研究设计
- 研究类型
- Observational
- 观察模型
- Case Only
- 时间视角
- Prospective
入排标准
- 年龄范围
- 18 Years 至 —（Adult, Older Adult）
- 性别
- All
- 接受健康志愿者
- 否
入选标准
- •Both genders
- •Over 18 years old
- •Diagnosis of rheumatoid arthritis according to ACR criteria
- •Patients that initiate treatment with anti-TNF drugs according to clinical practice, both in naïve anti-TNF patients and patients after first anti-TNF failure
- •Patients able to follow the protocol requirements
- •Patients that signed the informed consent
排除标准
- •Patients with known hypersensitivity to investigational products
- •Patients with tuberculosis, or severe infections like sepsis or opportunistic infections
- •Patients with moderate/severe cardiac insufficiency (NHYA classification Class III/IV)
- •Patients that according to the investigator criteria can not participate in the study or complete the study questionnaires
- •Pregnant or fertile woman that does not use a contraception method
研究组 & 干预措施
Anti-TNF
干预措施: Anti-TNF (Drug)
结局指标
主要结局
Anti-TNF treatment response based on circulant cyclic citrullinated anti-peptide antibodies.
时间窗: 24 weeks
Anti-TNF treatment response based on circulant rheumatoid factor
时间窗: 24 weeks
次要结局
未报告次要终点
研究者
研究点 (19)
Loading locations...
相似试验
Unknown
不适用
CTHRC1: A Biomarker for Evaluation of Rheumatoid Arthritis Disease ActivityRheumatoid ArthritisNCT04415502Assiut University100
已完成
3 期
Study Evaluating the Efficacy and Safety of Etanercept in Chinese Subjects With Rheumatoid ArthritisArthritis, RheumatoidNCT00443950Wyeth is now a wholly owned subsidiary of Pfizer150
招募中
不适用
Korean nation-wide prospective multicenter cohort for rheumatoid arthritisDiseases of the musculo-skeletal system and connective tissueKCT0000086Hanyang University3,000
Unknown
不适用
A Retrospective Cohort Study on the Risk of Serious Infections in Rheumatoid Arthritis Patients Receiving TocilizumabInfectionRheumatoid ArthritisNCT04115423Sungkyunkwan University9,508
招募中
不适用
Prospective cohort study of rheumatoid arthritis and Sjogren's syndrome (Prevention against the development of rheumatoid arthritis, collaboration with Kanazawa, Chiba and Nagasaki UniversityEarly arthritisJPRN-UMIN000014881agasaki University Hospital250