Checking the effect of "lycopene supplement" when consumed orally after non-surgical gum therapy.

Phase 1

Completed

Brief Summary: The roleof dietary antioxidant in disease prevention has received much attention inrecent years. Diet rich in antioxidant are found to be anti â€“inflammatory. Assuggested previously, the boosting of antioxidant micronutrient status ofchronic periodontitis patient may have adjunctive therapeutic benefits.

Severalstudies have demonstrated that patients with periodontitis have significantlylower serum antioxidant levels compared to healthy controls.

Nonsurgical periodontal therapy byitself can reverse this trend and partly restore antioxidant levels but thetherapy by alone may not have the desired benefits. It has been suggested thatphyto-nutritional intervention in the form of antioxidant supplementation mayhave a beneficial effects through direct scavenging of reactive oxygen species (ROS)

Thereactive oxygen species is mainly measured indirectly as the free radicals areso reactive and short lived that direct measurement is usually not possible.

Thus ROS is measured from the oxidative by-products of lipidsproteins and nucleic acids. Uric acid as an end product of purine metabolism, isthe most important endogenous antioxidant and acts as a potent free radicalscavenger. Lycopene also acts as same.

Recruitment & Eligibility

Inclusion Criteria

Exclusion Criteria

Primary Outcome Measures

Name	Time	Method
When lycopene given as supplement after scaling and root planing, it will show better healing.	Clinical parameters will be checked at baseline, 1 month and 3 months after research.

Secondary Outcome Measures

Name	Time	Method

Locations (1): Department of Periodontology and Implantology
🇮🇳
Nashik, MAHARASHTRA, India
Department of Periodontology and Implantology
🇮🇳Nashik, MAHARASHTRA, India
Dr Ravi Prabhu
Principal investigator
9923012840
ravimprabhu90@gmail.com