Neurobehavioral Moderators of Post-traumatic Disease Trajectories
Completed
- Conditions
- TraumaPTSD
- Registration Number
- NCT03756545
- Lead Sponsor
- Tel-Aviv Sourasky Medical Center
- Brief Summary
The research goal is to uncover the neurocognitive moderators of PTSD trajectories, by documenting clinical symptoms, cognitive functioning, and brain structure and function, one-, six- and fourteen months following a traumatic event, in a large population of survivors at initial high risk for PTSD.
- Detailed Description
Not available
Recruitment & Eligibility
- Status
- COMPLETED
- Sex
- All
- Target Recruitment
- 173
Inclusion Criteria
- Age 18 - 65 years
- Able to read and comprehend Hebrew
- Arrived in the ER because of one of the following: car accidents, terrorist attacks, work accidents, home accidents, burns, physical assault, large-scale disaster.
Exclusion Criteria
- Individuals with known claustrophobia
- Individuals with history of substance abuse
- Individuals with current or past psychotic or bipolar I disorder
- Individuals with chronic PTSD at the time of the current trauma
- Individuals on psychotropic medication or recreational drugs in the week that precedes the MRI
- Individuals with hearing problems
- Individuals with head trauma with coma exceeding 30 minutes
- Individuals which can't perform MRI due to safety reasons (e.g. irremovable metals in their body)
Study & Design
- Study Type
- OBSERVATIONAL
- Study Design
- Not specified
- Primary Outcome Measures
Name Time Method Change in CAPS Total Scores one-, six- and fourteen months following a traumatic event The Clinician-Administered PTSD Scale, used to assess PTSD diagnostic status and symptom severity. CAPS total symptom severity score is calculated by summing severity scores for all PTSD symptoms. We use both CAPS-V (according to DSM-4) and CAPS-5 (according to DSM-5).
- Secondary Outcome Measures
Name Time Method
Trial Locations
- Locations (1)
Tel-Aviv Sourasky Medical Center
🇮🇱Tel-Aviv, Israel