Hemodynamic stability during anesthesia induction with ketofol mixture – identifying optimal ratio

Not Applicable

Completed

• Conditions: Surgery; Elective surgery with orotracheal intubation

• Registration Number: ISRCTN59349598
• Lead Sponsor: niversity Clinical Centre Maribor

Brief Summary

Not available

Detailed Description

Not available

Study Timeline

• Study Start: 2017-08-02
• Last Update Posted: 4 September 2017

Recruitment & Eligibility

• Status: Completed
• Sex: All
• Target Recruitment: 100

Inclusion Criteria

1. Aged 18-80 years
2. ASA Physical Status I or II
3. Elective surgery with orotracheal intubation

Exclusion Criteria

1. Allergy or sensitivity to any medication used in trial
2. Alcohol or drug abuse
3. Chronical use of benzodiazepins, opiats or psyhothrophic medication
4. Body mass index higher than 35 or lower than 15
5. Anticipated difficult intubation (Mallampati III or IV)
6. Untreated arterial hypertension
7. Patients with Alzheimers, epilepsy or psychosis

Study & Design

• Study Type: Interventional
• Study Design: Not specified

Primary Outcome Measures

Name	Time	Method
1. Cardiac output is measured noninvasively using transthoracal electric bioimpedance every minute for first 16 minutes after induction of anesthesia<br>2. Blood pressure is measured noninvasively using arm cuffs every 2 minutes for first 16 minutes after induction of anesthesia<br>3. Heart rate is measured by ECG every minute for first 16 minutes after induction of anesthesia

Secondary Outcome Measures

Name	Time	Method
1. Bispectral index (BIS) (depth of sedation or anaesthesia) is monitored with 15 seconds sampling using forehead electrodes every minute for first 16 minutes after induction of anesthesia.<br>2. Dose titrated to clinical effect (loss of palpebral effect)